Rapidly progressing breast cancer (poussée Évolutive) in Tunisia: Studies on delayed hypersensitivity

Mourali, N; Levine, Paul H.; Tabanne, Francoise; Belhassen, S; Bahi, Jacqueline; Bennaceur, Meri; Herberman, Ronald B.

doi:10.1002/ijc.2910220102

Cited by 18 publications

(11 citation statements)

References 8 publications

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“…Fifth, the finding that inflammatory breast cancer patients in Tunis reacted to soluble breast cancer antigen with a frequency three times greater than the reaction in other types of breast cancer patients was unexpected and quite contrary to what was anticipated [22]. This study complements the findings of Stewart and Orizaga [25] and suggested an augmented host reactivity in this subset of breast tumors that have the worst prognosis.…”

Section: Paradoxical or Anomalous Observationssupporting

confidence: 47%

“…No correlation Griffith et al [12] 77 3 Elston et al [13] 1562 10 Bad prognosis Leitch [14] 5 Months Schumann [15] 11 Months Learmonth [16] 46 5 Lee and Tannenbaum [17] 28 5 Pfahler and Case [18] 15 5 Taylor and Meltzer [19] 38 2 Droulias et al [20] 75 18 Lucas and Perez-Mesa [21] 58 5 Mourali et al [22] 145 NA Levine et al [23] 134 (42) NA Costa et al [24] 94 NA Stewart and Orizaga [25] 56 5 Champion et al [26] 496 6 Morrison et al [27] 253 3 Fisher et al [28] 62 NA Flores et al [29] 95 10 Meyer and Hixon [30] 133 5 Fisher et al [31] 522 5 Fisher et al [32] 522 5 Parkes et al [33] 34 11 Rosen and Groshen [34] 644 18 van Netten et al [35] 25 NA Pupa et al [36] 1200 19…”

Section: Authormentioning

confidence: 99%

“…Mourali et al [22], Tunis, 1978. One hundred and forty-five cases with pathologically confirmed carcinoma of the breast were evaluated.…”

Section: First Seriesmentioning

confidence: 99%

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The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer

Stewart

Tsai²

1993

Clin Exp Metast

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This review examines the evidence that a subset of patients with breast cancer have tumors that are stimulated to grow by host cells in the tumor stroma. The search for such a minority group was prompted by the following observations. Adjuvant chemotherapy which is immunosuppressive improves disease-free interval and survival, whereas non-specific immunostimulation worsens the prognosis. Intrinsic immune reactivity is associated with a poor prognosis. A subset of tumors with a bad prognosis has anaplastic cells, dermal lymphatic invasion and a moderate to intense lymphoplasmacytic stromal infiltrate. Evidence is reviewed that adjuvant chemotherapy may be beneficial by virtue of its immunosuppressive effects in addition to tumor kill of minimal residual disease.

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Section: Paradoxical or Anomalous Observationssupporting

confidence: 47%

Section: Authormentioning

confidence: 99%

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The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer

Stewart

Tsai²

1993

Clin Exp Metast

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“…Delayed hypersensitivity studies using microbial antigens and in vitro studies including lymphocyte transformation tests and measurements of B and T cells indicated that cases with rapid progression and IBC-like symptoms had an immune response comparable to that of other breast cancer patients, suggesting that rapidly progressing breast cancer is not a reflection of immunodeficiency [59]. In fact, a greater reaction to breast-tumorrelated antigens was elicited in breast cancer patients with IBC-like symptoms than in other breast cancer patients [67], suggesting a hyperimmune response in those with rapidly progressing breast cancer. It is notable that other evidence also suggests that the immune response may facilitate breast cancer development.…”

Section: Immunologic Factorsmentioning

confidence: 89%

“…The etiology of IBC has been examined in one case-case study of 68 IBC cases in the United States [24] and one case-case study in Pakistan [12]. The etiology of rapidly progressing breast cancer, which encompasses IBC as well as milder forms of the disease, has also been studied in case-comparison studies conducted in Tunisia in the 1970s and 1980s [58,59,67,68,83]. Information on associated factors is also available from case series.…”

Section: Analytic Datamentioning

confidence: 99%

Epidemiology of Inflammatory Breast Cancer (IBC)1

Anderson

Schairer

Chen

et al. 2006

Self Cite

223

170

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Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer with unknown etiology and generally poor outcome. It is characterized by diffuse edema (peau d'orange) and redness (erythema), although either the disease itself or case definitions have varied over time and place, confounding temporal trends and geographic variations. In this review, we discuss case definitions for IBC and its clinical characteristics; describe its geographic variation, age and racial distribution, incidence and survival patterns, and summarize the very limited information on its epidemiologic risk factors. We also incorporate emerging data from the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) Program. KeywordsInflammatory breast cancer; epidemiology; etiologic factors Case Definition for Inflammatory Breast Cancer (IBC)IBC is an aggressive and lethal form of breast cancer. It is characterized by the clinical appearance of inflammation, with edema and redness of the breast. However, the appearance of inflammation is not due to true physiologic inflammatory response but rather due to pathologic plugging of the dermal lymphatics of the breast with tumor emboli. This condition was first described in 1814 by Sir Charles Bell [14]; but, it was not until 1924 that the term inflammatory breast cancer was proposed by Lee and Tannebaum at the suggestion of James Ewing [56,88]. Prior to this designation, IBC was referred to as von Volkmann's or Wokmann's syndrome in pregnant women, lactation cancer, carcinoma mastitoides, mastitis carcinomatosa, acute encephaloid cancer, acute mammary carcinoma, acute mammary carcinomatosis, acute brawny cancer, acute scirrhous carcinoma, acute medullary carcinoma or carcinoma telangiectaticum [42,53,55,57,71,75,82,90,92]. In all, these expressions implied an acute and aggressive breast cancer, more of a clinical than a pathological entity, often multifocal [13,18,19,33,38,66,75,92], and occurring in young women during pregnancy or lactation [53,55,75,90].The extent of clinical signs required for IBC has not been standardized and has varied from any edema (peau d'orange) and redness (erythema) to edema and redness covering the entire

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Breast cancer skin test antigens of increased sensitivity prepared from vesicular stomatitis virus-infected tumor cells

Austin

Boone

Levin

et al. 1982

Cancer

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Crude membrane (CM) extracts were prepared from five cultured breast tumor lines (MDA-MB-157, MDA-MB-231, ZR75-1, HS0578T, and MCF-7) which had been infected with vesicular stomatitis virus (VSV) to augment their antigenicity. In skin test trials, CM extracts of uninfected MCF-7 cells elicited positive response in 0 of 13 (0%) tests in breast cancer patients, while VSV-MCF-7 elicited positive responses in 11 of the same 13 patients (84.6%). CM extracts of VSV-ZR75-1 and VSV-MCF-7 elicited greater delayed hypersensitivity responses (mm induration at 48 hr) in breast cancer patients than in patients with lung carcinoma or melanoma. Although the sensitivity of VSV-ZR75-1 was too low (ten of 28, or 35.7% of tests positive) to be useful as a skin test antigen, VSV-MCF-7 elicited positive responses in 30 of 38 (78.9%) tests in breast cancer patients, as compared to two of 15 (13.3%) and two of 13 (15.4%) of tests in patients with lung carcinoma and melanoma, respectively. The "virus-augmented" CM extract of cultured MCF-7 cells exhibited markedly greater sensitivity as compared to control MCF-7 extracts (P less than .005), with a high degree of specificity for breast cancer patients as compared to patients with the other neoplasms (P less than .00001). The results of skin testing with VSV-MCF-7 CM extracts demonstrated antigenic cross-reactivity with a large number of breast cancer patients, a finding of great importance for any potential immunotherapy and/or immunodiagnosis.

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Rapidly progressing breast cancer (poussée Évolutive) in Tunisia: Studies on delayed hypersensitivity

Cited by 18 publications

References 8 publications

The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer

The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer

Epidemiology of Inflammatory Breast Cancer (IBC)1

Breast cancer skin test antigens of increased sensitivity prepared from vesicular stomatitis virus-infected tumor cells

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