The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer

Stewart, T. H. M.; Tsai, Shaw-Jeng

doi:10.1007/bf00058049

Cited by 30 publications

(15 citation statements)

References 37 publications

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“…Breast tumours often contain large infiltrates of lymphocytes but the functional or prognostic significance of these cells is not clear despite decades of study (Stewart and Tsai, 1993;O'Sullivan and Lewis, 1994). Although it has been possible to isolate T cells that have cytolytic activity against the tumour in vitro, these cells seem to be unable to control tumour growth in vivo (Whiteside et al, 1986;Jerome et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Intracellular Fas ligand in normal and malignant breast epithelium does not induce apoptosis in Fas-sensitive cells

et al. 2000

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Fas ligand (FasL) is expressed on some cancers and may play a role in the immune evasion of the tumour. We used immuno-histochemistry to study the expression of Fas and FasL in tissue samples from breast cancer patients, as well as normal breast tissue. Our results show that Fas and FasL are co-expressed both in normal tissue and in breast tumours. Fas and FasL mRNA were expressed in fresh normal and malignant breast tissue, as well as cultured breast epithelium and breast cancer cell lines. Flow cytometry analysis of live cells failed to detect FasL on the surface of normal or malignant breast cells; however, both stained positive for FasL after permeabilization. Fas was detected on the surface of normal breast cells and T47D and MCF-10A cell lines but only intracellularly in other breast cell lines tested. Neither normal breast epithelium nor breast cell lines induced Fas-dependent apoptosis in Jurkat cells. Finally, 20 tumour samples were stained for apoptosis. Few apoptotic cells were detected and there was no increase in apoptotic cells on the borders between tumour cells and lymphocytes. We conclude that FasL is expressed intracellularly in both normal and malignant breast epithelium and unlikely to be important for the immune evasion of breast tumours. © 2000 Cancer Research Campaign http://www.bjcancer.com

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Section: Discussionmentioning

confidence: 99%

Intracellular Fas ligand in normal and malignant breast epithelium does not induce apoptosis in Fas-sensitive cells

et al. 2000

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“…Others have shown T cells to be a favourable prognostic sign, whereas B cells are generally not predominant in various human cancers (Shimokawara et al, 1982). In contrast, some reports show evidence that tumours are stimulated into growth by host cells in the tumour stroma (Stewart and Tsai, 1993). In this context, in vitro studies demonstrated that tumour-infiltrating leucocytes display an immune inhibitory effect (Fulton, 1987;Vose and Bonnard, 1982).…”

Section: Discussionmentioning

confidence: 99%

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

Esteban

Redondo²,

Delgado³

et al. 1996

Br J Cancer

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Summary Alteration in MHC class I expression may be used by cancer cells to avoid immune destruction. Much experimental evidence supports this idea, although survival studies are very scarce. To investigate whether the presence or absence of HLA-A, -B and -C antigens in laryngeal carcinoma influences survival, a series of 60 primary laryngeal tumours treated surgically and normal tissues were evaluated in frozen sections for the expression of MHC class I antigens and tumour-infiltrating leucocytes (CD3, CD4, CD8, CD1Ib, CD1, CD20 and CDI6), using monoclonal antibodies and the APAAP technique. Long-term follow-up from the patients is available, ranging from 6 to 10 years. Thirteen tumours presented total HLA-ABC loss, five selective losses of HLA-A antigens and one absence of HLA-B antigens. Total losses were statistically associated with several clinical and pathological parameters, but there were no differences regarding tumour-infiltrating leucocytes. After conducting a prospective study, only T and N staging and scoring according to Glanz's malignancy classification were found to be independently related to patients' outcome. From our data, we conclude that neither complete loss of HLA class I antigens nor tumour-infiltrating leucocytes appear to influence survival in squamous cell carcinoma of the larynx.

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“…Adjuvant chemotherapy, in addition to its direct cytotoxic effect on cancer cells, might also attenuate surgery-stimulated tumour cell proliferation and angiogenic surge possibly occurring at distant dormant or indolent micrometastases (Retsky et al, 2004). Furthermore, adjuvant chemoradiotherapy may be effective by virtue of its cellular immune suppression and modification of specific host immunerelated mechanisms (Reizenstein et al, 1985;Stewart and Tsai, 1993).…”

Section: Discussionmentioning

confidence: 99%

The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer

et al. 2008

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The significance of the inter-relationship between tumour and host local/systemic inflammatory responses in primary operable invasive breast cancer is limited. The inter-relationship between the systemic inflammatory response (pre-operative white cell count, C-reactive protein and albumin concentrations), standard clinicopathological factors, tumour T-lymphocytic (CD4 þ and CD8 þ ) and macrophage (CD68 þ ) infiltration, proliferative (Ki-67) index and microvessel density (CD34 þ ) was examined using immunohistochemistry and slide-counting techniques, and their prognostic values were examined in 168 patients with potentially curative resection of early-stage invasive breast cancer. Increased tumour grade and proliferative activity were associated with greater tumour T-lymphocyte (Po0.05) and macrophage (Po0.05) infiltration and microvessel density (Po0.01). The median follow-up of survivors was 72 months. During this period, 31 patients died; 18 died of their cancer. On univariate analysis, increased lymph-node involvement (Po0.01), negative hormonal receptor (Po0.10), lower albumin concentrations (Po0.01), increased tumour proliferation (Po0.05), increased tumour microvessel density (Po0.05), the extent of locoregional control (Po0.0001) and limited systemic treatment (Pp0.01) were associated with cancer-specific survival. On multivariate analysis of these significant covariates, albumin (HR 4.77, 95% CI 1.35 -16.85, P ¼ 0.015), locoregional treatment (HR 3.64, 95% CI 1.04 -12.72, P ¼ 0.043) and systemic treatment (HR 2.29, 95% CI 1.23 -4.27, P ¼ 0.009) were significant independent predictors of cancer-specific survival. Among tumour-based inflammatory factors, only tumour microvessel density (Po0.05) was independently associated with poorer cancerspecific survival. The host inflammatory responses are closely associated with poor tumour differentiation, proliferation and malignant disease progression in breast cancer.

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The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer

Cited by 30 publications

References 37 publications

Intracellular Fas ligand in normal and malignant breast epithelium does not induce apoptosis in Fas-sensitive cells

Intracellular Fas ligand in normal and malignant breast epithelium does not induce apoptosis in Fas-sensitive cells

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer

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