Specificity of Increased Amylase to Creatinine Clearance Ratio in Acute Pancreatitis

Lankisch, P. G.; Koop, H.; Otto, J.; Oberdieck, U.; Winckler, K.; Wolfrum, D. I.

doi:10.1159/000198066

Cited by 22 publications

(5 citation statements)

References 3 publications

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“…In patients with pancreatitis this ratio is increased and may exceed 10%. Although an increased ACCR was thought to be helpful for the diagnosis, it has been shown to have little value because of its low specificity [19][20][21][22][23].…”

Section: Urinary a Mylasementioning

confidence: 99%

Diagnostic standards for acute pancreatitis

1997

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An accurate history and thorough physical examination will often raise clinical suspicion of acute pancreatitis in the differential diagnosis of a patient presenting with acute abdominal pain. An accurate diagnosis is needed to eliminate etiologies of acute abdominal pain and to appropriately direct therapy. Confirmation of the diagnosis is most often made by evaluation of serum amylase and lipase levels. Although hyperamylasemia is found in the majority of patients with acute pancreatitis, other nonpancreatic acute abdominal conditions may be present with hyperamylasemia. CT scanning provides an accurate confirmation of clinical and laboratory findings and offers excellent anatomic and morphologic representation of the pancreas and peripancreatic tissue. The following article, written by the late John H.C. Ranson, presents a discussion of the modalities available for diagnosing acute pancreatitis.

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Section: Urinary a Mylasementioning

confidence: 99%

Diagnostic standards for acute pancreatitis

1997

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“…While some confirmed the value of this investigation (2 -5 ), others demonstrated that a normal CAm/CCr does not exclude acute pancreatitis (6 -8 ) as has been previously sug gested (9). Furthermore, other groups question the specificity of the CAm/Ccr> reporting raised values in several conditions other than pancre atitis: bums and ketoacidosis (10), acute duo denal perforation (11), renal insufficiency (6,8,(12)(13)(14) and thoracic operation (15,16).…”

Section: Warshaw and Fullermentioning

confidence: 99%

Amylase/Creatinine Clearance Ratio and Tubular Proteinuria in Acute Pancreatitis

Lankisch¹,

Wolfrum²,

Koop³

et al. 1979

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Amylase/creatinine clearance ratio (C_Am/C_cr), urinary protein concentration and urinary protein pattern were studied in 102 samples from 27 patients with acute pancreatitis and in 46 controls. Raised C_Am /C_cr, proteinuria and a tubular protein pattern were present in 74, 56 and 96% of the patients, respectively. However, C_Am/C_Cr and proteinuria and C_Am/C_Cr and tubular protein pattern were not correlated. These results do not support the suggestion that an elevated C_Am/C_Cr in acute pancreatitis is due to generalized tubular protein reabsorption failure presenting with tubular proteinuria.

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“…They postulated that the Cam/Ccr ra tio may be a useful tool to distinguish hyperamylasemia due to pancreatitis from that caused by other diseases. The diagnostic value of this test has not been confirmed by other groups [6,7], 1.1.4. Isoamylase Isoamylase determination in serum, urine, and other body fluids potentially in creases the specificity of the conventional amylase test.…”

Section: Urine Amylasementioning

confidence: 67%