SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

Lilius, Tuomas; Rosenholm, Marko; Klinger, Laura; Mortensen, Kristian Nygaard; Sigurðsson, Björn; Mogensen, Frida Lind-Holm; Hauglund, Natalie L.; Nielsen, Malthe Skytte Nordentoft; Rantamäki, Tomi; Nedergaard, Maiken

doi:10.1016/j.isci.2022.105250

Cited by 7 publications

(9 citation statements)

References 52 publications

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“…This may ultimately lead towards additional information about how neurodegenerative illnesses affect glymphatic drainage. 81 The CSF's impulse may be seen and the entire brain can be seen in 100 milliseconds with ultrafast MREG. This will enable more accurate mapping and exploration of the glymphatic CSF flow pulsating patterns using MREG wave analysis.…”

Section: Imaging Approaches and Advanced Technologies Used To Visuali...mentioning

confidence: 99%

“…When compared to contrast‐enhanced MRI, SPECT/CT imaging offers a better knowledge of the glymphatic drug delivery pathway, facilitating the determination of a tracer's clearance from the injection site and the use of less amount of the tracer. This may ultimately lead towards additional information about how neurodegenerative illnesses affect glymphatic drainage 81 …”

Section: Comprehensive Overview Of Glymphatic Systems's Anatomy and I...mentioning

confidence: 99%

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Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases

Rehman,

Sehar,

Rasool

et al. 2024

Int J Geriat Psychiatry

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The central nervous system (CNS) is widely recognized as the only organ system without lymphatic capillaries to promote the removal of interstitial metabolic by‐products. Thus, the newly identified glymphatic system which provides a pseudolymphatic activity in the nervous system has been focus of latest research in neurosciences. Also, findings reported that, sleep stimulates the elimination actions of glymphatic system and is linked to normal brain homeostatis. The CNS is cleared of potentially hazardous compounds via the glymphatic system, particularly during sleep. Any age‐related alterations in brain functioning and pathophysiology of various neurodegenerative illnesses indicates the disturbance of the brain's glymphatic system. In this context, β‐amyloid as well as tau leaves the CNS through the glymphatic system, it's functioning and CSF discharge markedly altered in elderly brains as per many findings. Thus, glymphatic failure may have a potential mechanism which may be therapeutically targetable in several neurodegenerative and age‐associated cognitive diseases. Therefore, there is an urge to focus for more research into the connection among glymphatic system and several potential brain related diseases. Here, in our current review paper, we reviewed current research on the glymphatic system's involvement in a number of prevalent neurodegenerative and neuropsychiatric diseases and, we also discussed several therapeutic approaches, diet and life style modifications which might be used to acquire a more thorough performance and purpose of the glymphatic system to decipher novel prospects for clinical applicability for the management of these diseases.

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Section: Imaging Approaches and Advanced Technologies Used To Visuali...mentioning

confidence: 99%

Section: Comprehensive Overview Of Glymphatic Systems's Anatomy and I...mentioning

confidence: 99%

Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases

Rehman,

Sehar,

Rasool

et al. 2024

Int J Geriat Psychiatry

View full text Add to dashboard Cite

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“…Another study in rats found that the administration of hypertonic saline enhanced the glymphatic delivery of intrathecally administered agents [7]. Researchers found that hypertonic saline improved the brain-wide availability of administered small gold nanoparticles and also found that these particles were quickly removed from the body, decreasing the concern of renal toxicity [56].…”

Section: Spect/ct Imagingmentioning

confidence: 99%

“…Researchers found that hypertonic saline improved the brain-wide availability of administered small gold nanoparticles and also found that these particles were quickly removed from the body, decreasing the concern of renal toxicity [56]. The researchers used SPECT/CT imaging to quantify the extent of clearance of the tracer from the injection site while also determining the tracer distribution within the animal's body [7]. Compared with MRI, SPECT/CT is more sensitive and allows for smaller tracer volumes to be detected [7].…”

Section: Spect/ct Imagingmentioning

confidence: 99%

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Mapping the Glymphatic Pathway Using Imaging Advances

Thakkar,

Kioutchoukova,

Griffin

et al. 2023

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The glymphatic system is a newly discovered waste-clearing system that is analogous to the lymphatic system in our central nervous system. Furthermore, disruption in the glymphatic system has also been associated with many neurodegenerative disorders (e.g., Alzheimer’s disease), traumatic brain injury, and subarachnoid hemorrhage. Thus, understanding the function and structure of this system can play a key role in researching the progression and prognoses of these diseases. In this review article, we discuss the current ways to map the glymphatic system and address the advances being made in preclinical mapping. As mentioned, the concept of the glymphatic system is relatively new, and thus, more research needs to be conducted in order to therapeutically intervene via this system.

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Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

Lilius

Mortensen

Deville

et al. 2023

Journal of Controlled Release

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SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

Cited by 7 publications

References 52 publications

Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases

Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases

Mapping the Glymphatic Pathway Using Imaging Advances

Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

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