Spectral analysis of EEG gamma rhythms associated with tonic seizures in Lennox–Gastaut syndrome

Kobayashi, Katsuhiro; Inoue, Tetsuyoshi; Watanabe, Yoshiaki; Oka, Makio; Endoh, Fumika; Yoshinaga, Harumi; Ohtsuka, Yoko

doi:10.1016/j.eplepsyres.2009.03.011

Cited by 26 publications

(22 citation statements)

References 17 publications

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“…60 More importantly, the first studies on scalp interictal HFO events (70–200 Hz) were published in children with electrical status epilepticus during slow wave sleep, 14 as well as in idiopathic partial epilepsies of childhood. 61 The first study on interictal HFOs in adults with focal epilepsy was published in 2011.…”

Section: Hfos As Markers Of the Epileptogenic Zonementioning

confidence: 99%

High‐frequency oscillations: The state of clinical research

et al. 2017

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Summary Modern electroencephalographic (EEG) technology contributed to the appreciation that the EEG signal outside the classical Berger frequency band contains important information. In epilepsy, research of the past decade focused particularly on interictal high-frequency oscillations (HFOs) > 80 Hz. The first large application of HFOs was in the context of epilepsy surgery. This is now followed by other applications such as assessment of epilepsy severity and monitoring of antiepileptic therapy. This article reviews the evidence on the clinical use of HFOs in epilepsy with an emphasis on the latest developments. It highlights the growing literature on the association between HFOs and post-surgical seizure outcome. A recent meta-analysis confirmed a higher resection ratio for HFOs in seizure-free versus non–seizure-free patients. Residual HFOs in the postoperative electrocorticogram were shown to predict epilepsy surgery outcome better than preoperative HFO rates. The review further discusses the different attempts to separate physiological from epileptic HFOs, as this might increase the specificity of HFOs. As an example, analysis of sleep microstructure demonstrated a different coupling between HFOs inside and outside the epileptogenic zone. Moreover, there is increasing evidence that HFOs are useful to measure disease activity and assess treatment response using noninvasive EEG and magnetoencephalography. This approach is particularly promising in children, because they show high scalp HFO rates. HFO rates in West syndrome decrease after adrenocorticotropic hormone treatment. Presence of HFOs at the time of rolandic spikes correlates with seizure frequency. The time-consuming visual assessment of HFOs, which prevented their clinical application in the past, is now overcome by validated computer-assisted algorithms. HFO research has considerably advanced over the past decade, and use of noninvasive methods will make HFOs accessible to large numbers of patients. Prospective multicenter trials are awaited to gather information over long recording periods in large patient samples.

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Section: Hfos As Markers Of the Epileptogenic Zonementioning

confidence: 99%

High‐frequency oscillations: The state of clinical research

et al. 2017

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“…Important emerging data show that HFOs can be detected on scalp EEG. Ictally, HFOs has been reported at the onset of epileptic spasms on scalp recordings in children (50–100 Hz, Kobayashi et al, 2004; 40–120 Hz, Inoue et al, 2008), as well as at the onset of tonic seizures in Lennox–Gastaut Syndrome (50–100 Hz, Kobayashi et al, 2009). …”

Section: Clinical Aspects Of Hfos In Epilepsymentioning

confidence: 99%

High-frequency oscillations (HFOs) in clinical epilepsy

Jacobs

Staba

Asano

et al. 2012

Progress in Neurobiology

386

349

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“…This increases the population for whom HFO analysis is available, beyond the small group of drug-resistant focal epilepsy patients who are candidates for surgery with intracerebral electrodes. Reports describe 50-100 Hz activity in ictal recordings (Kobayashi et al, 2004(Kobayashi et al, , 2009, ripples in interictal EEG in adults with focal epilepsy (Andrade-Valenca et al, 2011;Melani et al, 2013;Zelmann et al, 2013), in children with continuous spike and wave in slow-wave sleep (Kobayashi et al, 2010), and idiopathic partial epilepsy (Kobayashi et al, 2011). A recent study showed that interictal surface ripples decrease after treatment with ACTH in children with West Syndrome (Kobayashi et al, 2015).…”

Section: Introductionmentioning

confidence: 96%