Spectral analysis of electroencephalogram during sleep-related apneas in pre-term and term born infants in the first weeks of life

Schramm, Dieter; Scheidt, B; Hübler, Axel; Frenzel, J; Holthausen, Klaus; Breidbach, Olaf

doi:10.1016/s1388-2457(00)00417-x

Cited by 15 publications

(16 citation statements)

References 12 publications

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“…Immediately before the apnea onset and in the course of the apnea, significant changes in EEG activity (a decrease of amplitude and a shift towards higher frequencies) have been observed in preterm infants. These changes have been interpreted as a sign of "arousal reaction" [35]. Both latter findings indicate, in agreement with our results, that in preterm infants, the onset of apnea may be associated with the activation of the nervous system.…”

Section: No Of Eventssupporting

confidence: 92%

“…It is known that EEG activity in preterm infants is characterized by the decrease of the amplitude when reacting to sudden stimuli. Sudden flattening of the curves (decrease of the amplitude below 50 mmV) in all EEG channels for at least 3 s was assessed as an "arousal reaction" [13,22,35,42].…”

Section: Methodsmentioning

confidence: 99%

“…At the earliest age, the criteria used in adults cannot be applied [6]. Various symptoms of arousal in preterm infants are discussed by different authors [6,13,17,22,35,42]: (a) sudden changes in respiratory patterns, (b) sudden changes in heart rate, (c) increase of EMG activity, (d) sudden motor or behavioral phenomenon, and (e) changes in the amplitude and frequency of EEG activity. In the above-mentioned studies, arousal is defined in a different way, most often on the basis of presence of one to three symptoms described.…”

Section: No Of Eventsmentioning

confidence: 99%

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Differential diagnosis of apneas in preterm infants

et al. 2008

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Clinically relevant apneas, which are common in preterm infants, may adversely affect later neuropsychological condition in this group of patients. Pharmacotherapy to stimulate respiratory functions may be unsuccessful. Polygraphic recording may help in the differential diagnosis of these clinically relevant events. Twenty-nine preterm neonates born before 36 weeks of gestational age were examined using polygraphic recording (respiration--two channels, perioral electromyography, oxygen saturation, heart rate, electroencephalography, electrocardiography, electrooculography). The examination was ordered by the attending physician after an unsuccessful treatment of apnea by Aminophylline, and it should contribute to the clarification of the causes of these events. In the course of the polygraphic examinations, altogether 63 episodes were recorded during which the pulse oximeter alarm signal was set off. In 42 cases, the alarm signal was set off in events during which SaO(2) fell below 85%. In the remaining 21 cases, the alarm signal was set off in episodes during which early bradycardia below 90/min occurred. The onset of apnea was very often associated with the phasic increase of the perioral electromyography and with electroencephalography arousal reaction. Because of suspicion that these apneas may be triggered by episodes of gastroesophageal reflux, the interruption of the Aminophylline treatment and setting up an antireflux regimen were recommended. These therapeutic measures had a positive effect: The frequency of alarm signals decreased within 48 h by a statistically significant 50%. In cases where the pharmacotherapy of apnea by stimulation of respiratory functions is not successful, differential diagnostic analysis should be performed. Polygraphy may contribute to the clarification of the causes underlying clinically relevant apneas in a view of newly described polygraphic signs. It is feasible to suspect, based on these signs, that gastroesophageal reflux is the cause for clinically significant apneas in that case.

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Section: No Of Eventssupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: No Of Eventsmentioning

confidence: 99%

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Differential diagnosis of apneas in preterm infants

et al. 2008

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“…Fast-Fourier transform was initially applied to studies of full-term neonates [108][109][110][111][112] followed by more recent reports in preterm infants [113][114][115][116][117][118][119][120][121][122] . These algorithms were also used to describe specific neonatal and infant risk groups, such as sudden infant death syndrome [123] , apnea [117,124] , hyperbilirubinemia [125] , white matter necrosis [126] , and asphyxia [127] . These studies applied power analyses to only one specific physiologic behavior.…”

Section: Computer-assisted Analyses Of Neonatal Eeg/sleep Represent Amentioning

confidence: 99%

Neonatal EEG/Sleep State Analyses: A Complex Phenotype of Developmental Neural Plasticity

Scher

Loparo

2009

Dev Neurosci

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Computer analyses of EEG/sleep states can be used as physiologic biomarkers of developmental neural plasticity. Frequency- and time-dependent signal processing strategies of cerebral and noncerebral measures can help test current theories of neuronal network maturation in terms of segregation and integration of short-distance versus long-distance neuronal connections throughout the neuroaxis. Specific phenotypic expressions of adaptive or maladaptive neuronal connectivity are proposed based on comparisons of whole-brain EEG/sleep resting states between preterm and full-term cohorts when developmental outcome measures are applied. Combined use of neurophysiological datasets with neuroimaging and genetic methodologies define endophenotypes that will more accurately diagnose children at risk for developmental disorders, as well as design appropriate neuroprotective interventions for the individual’s age and disease progress.

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“…40 41 Schramm and colleagues 42 reported a reduction in the AP in various frequency ranges (0.4-19.5 Hz) during periods of central apnoeas in preterm and term infants. This reduction from baseline was present in the time periods before and after manifestation of an apnoea.…”

Section: Discussionmentioning

confidence: 99%

Prenatal three dimensional ultrasound detection of linear nevus sebaceous syndrome

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Ys³

et al. 2005

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Spectral analysis of electroencephalogram during sleep-related apneas in pre-term and term born infants in the first weeks of life

Cited by 15 publications

References 12 publications

Differential diagnosis of apneas in preterm infants

Differential diagnosis of apneas in preterm infants

Neonatal EEG/Sleep State Analyses: A Complex Phenotype of Developmental Neural Plasticity

Prenatal three dimensional ultrasound detection of linear nevus sebaceous syndrome

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