Spectral and Antimicrobial Studies of Organotin(iv) Complexes of Bidentate Schiff Bases Having Nitrogen and Sulphur Donor Systems

Abstract

The complexes of composition R 2 Sn(L)2 and RjSnL (where R = butyl and L = monoanion of Schiff bases of S-benzyldithiocarbazate) have been prepared by the reaction of Schiff bases with metal oxides. The newly synthesized complexes have been characterized by elemental analysis, conductance measurements and molecular weight determinations. The mode of bonding and geometry of the complexes have been suggested on the basis of IR, UV and multinuclear 'H, i3 C and Sn NMR spectral studies. Schiff bases and their tin complexes have also been screened for their antibacterial activities, as several bacteria are quite active in this respect. Preparation of S-benzyldithiocarbazateThis compound was prepared by the method of Bähr and Schleitzer[8], Since their details are rather brief and conditions for a high yield are critical, the method is given here in detail. Potassium hydroxide (28.5 g) was completely dissolved in alcohol (135 ml)-water (15 ml) mixture and the mixture was cooled in ice. To the solution hydrazine hydrate (25 g) was added slowly with stirring. A solution of carbon disulphide (36.5 g) in alcohol (30 ml) was then added dropwise from a burette, with constant stirring, over a period of Ihr. The temperature of the mixture was kept below 10 °C during the addition. The resulting yellow oil was separated by means of a separatory funnel and dissolved in alcohol (48 ml)-water (72 ml) mixture and this solution was cooled in ice. Benzyl chloride (62.16 g) was then added slowly with vigorous mechanical stirring; after the addition the mixture was stirred for a further 10 minutes while a white product separated. Ice-cooled water (100 ml) was and then added the stirring was continued for another 10 minutes. 5Brought to you by | Purdue University Libraries

Synthetic, Structural, and Biochemical Studies of Organotin(IV) with Schiff Bases Having Nitrogen and Sulphur Donor Ligands

“…Though the results suggest that the ligands have remarkable toxic property, their complexes of tin inhibit the growth of organisms to a greater extent. This is in accordance with the earlier reports [39]. Further, the greater activity of the complexes can also be explained on the basis of their higher solubility of the particles.…”

Synthesis, spectral, 3D molecular modeling and antibacterial studies of dibutyltin (IV) Schiff base complexes derived from substituted isatin and amino acids

“…Though the results suggest that the ligands have a remarkable toxic property, their complexes of tin inhibit the growth of microorganisms to a greater extent. This is in accordance with earlier reports [45]. Further, the greater activity of the complexes can also be explained on the basis of their higher solubility of the particles.…”

Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde

“…Though the results suggest that the ligands have a remarkable toxic property, their complexes of tin inhibit the growth of microorganisms to a greater extent. This is in accordance with earlier reports [35]. Further, the greater activity of the complexes can also be explained on the basis of their higher solubility of the particles.…”