Spectral and biological investigation of 5-hydroxyl-3-oxopyrazoline 1-carbothiohydrazide and its transition metal complexes

Abstract

Mononuclear complexes of 5-hydroxyl-3-oxopyrazoline-1-carbothiohydrazide, H 3 HOC, with VO 2þ , Co(II), Ni(II), Cu(II) and Cd(II) have been isolated. The elemental analyses, magnetic, spectral [u.v.-vis., i.r., e.s.r. 1 H n.m.r. and mass] with thermal analysis have been used to characterize the isolated complexes. The ligand behaves as a mononegative tridentate with Ni(II) and Co(II) ions and neutral bidentate in [Cu(H 3 HOC)ðNO 3 Þ 2 ]0.5H 2 O, [VO(H 3 HOC)SO 4 ] and [Cd(H 3 HOC)Cl 2 C 2 H 5 OH]C 2 H 5 OH complexes. The octahedral structure was suggested for all the isolated complexes except VO 2þ . The TG analyses recorded different decomposition steps started at a temperature, indicating thermally unstable complexes. Screening showed antimicrobial activity for Cd(II) and Ni(II) complexes against the investigated bacteria as well as a significant adverse effects on DNA but a moderate effect is displayed with the other complexes.

Synthesis, spectroscopy, thermal and biological aspect of novel six‐coordinated dimeric iron(III) mixed‐ligand complexes

“…This increase in biocidal activity may be due to Overtone's concept, [30] chelation theory [31] or to the effect of the metal ion on the normal cell process. The activity order for each bacteria is given as below.…”

Zeolite-Y entrapped bivalent transition metal complexes as hybrid nanocatalysts: density functional theory investigation and catalytic aspects

“…In the electronic 4 T 1g (F)→ 4 T 1g (P), and MLCT transitions of an octahedral geometry around the metal ion, respectively. The absorption spectrum of [Ni (SFCH)·3H 2 O]-Y exhibits two bands at 680 and 242 nm that may be attributed to 3 A 2g → 3 T 1g (P) (ν 3 ) and 3 A 2g → 3 T 1g (F) (ν 2 ) transitions, respectively (33). The electronic spectra of [Cu(SFCH)·H 2 O]-Y consists of a band at 253 nm and a shoulder at 321 nm, which can be assigned to the d xz,yz → d xy and MLCT transitions, respectively, for tetrahedrally distorted (D 2h ) mononuclear copper(II) complexes (34).…”

Synthesis, characterization, antimicrobial, SOD mimic and DNA interaction behavior of copper(II) complexes with pefloxacin and phenanthroline derivatives

“…3. The changes observed in the UV spectra of the complexes after mixing it with DNA (either the increase in intensity or the shift in the wavelength) indicate that the interaction of complexes with DNA takes place by a direct formation of a new complex with double‐helical DNA 38. The extent of the binding strength of complexes was quantitatively determined by calculating intrinsic binding constants ( K b ) of the complexes by monitoring the change in absorbance at various concentrations of DNA.…”