A reliable solid-state method for synthesizing GdPO4:Yb3+/Ho3+ nanophosphor is presented, exhibiting both up and down conversion luminescent properties. The peaks were observed at 460, 550, 640, and 750 nm after excitation at 300 nm, which is followed by nonradiative resonance energy transfer (ET) with the P-O charge transfer band of Ho3+ ions. A significant up-conversion nanophosphors by enhancing Ho3+ ion emissions is accomplished. The Ho3+ ion peaks at 542 and 635 nm were identified using a strong 980 nm laser source, leading to well-crystalline nanoparticles. The present results demonstrated an enormous potential of GdPO4:Yb3+/Ho3+ for high-quality, widespread luminescence. Due to their significant quantum yield when excited at a wavelength of 300 nm, these materials exhibit a diverse array of potential applications and hold considerable potential for advancement across several industries.