Spectral composition of artificial illuminants and their effect on eye growth in chicks

Yoon, Hannah; Taylor, Christopher; Rucker, Frances J

doi:10.1016/j.exer.2021.108602

Cited by 8 publications

(5 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Choroidal thinning is a particular anatomical change related to myopia in humans 47 , 48 and animal models. 36 , 49 In our study, form-deprivation induced choroidal thinning in FD eyes exposed to fluorescent light and SL-4000. However, the choroid was thicker overall in FD eyes exposed to SL-6500 than in those exposed to fluorescent light, and there was no choroidal thinning under SL-6500 on D7 and D14 of form-deprivation.…”

Section: Discussionmentioning

confidence: 47%

“…1 B), promoted a recovery from myopic refractive error to measures that were not significantly different from control eyes on D28 of the experimental protocol. Previous reports have also shown that blue-enriched white light (CCT = 9700 K) can slow axial elongation induced by FDM, and accelerate recovery from FDM in a chicken model, 26 whereas a recent study by Yoon et al 36 demonstrated that exposure to 985 lux of broad-spectrum light with a high blue content can slow axial elongation in chicks. Whether the effect of blue-enriched white light on recovery from experimental myopia is only due to LCA 46 or other additional phenomena remains unclear.…”

Section: Discussionmentioning

confidence: 96%

“… 30 Although many investigations have focused on the impact of intense light on experimental myopia development, 31 – 35 only a few have investigated the impact of the spectral characteristics of ambient, moderate intensity, visible white light on refractive error development. 15 , 26 , 36 …”

Section: Discussionmentioning

confidence: 99%

“…The spectral composition of light, more specifically narrow-band light, can affect ocular growth and refractive development of uncovered control eyes. 16 , 17 , 46 Furthermore, Yoon et al 36 reported that brighter broadband spectrum light around 1000 lux with increased blue content can reduce the axial elongation, whereas Najjar et al 26 reported a significant decrease in the AL, and increase in choroidal thickness of the control eyes exposed to blue enriched white lights with a CCT of 9700 K compared to 3900 K. The authors associated these observed changes with an increased blue content of the LED light. Such changes in the control eyes were not detected in our study.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Recovery From Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum

Muralidharan

Low

Lee

et al. 2022

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose The purpose of this study was to evaluate the impact of full-spectrum light-emitting diodes mimicking sunlight (Sunlike LEDs) on ocular growth and refractive error development in a chicken model of myopia. Methods One-day old chicks ( n = 39) were distributed into 3 groups and raised for 28 days in isoluminant (approximately 285 lux) fluorescent ( n = 18, [FL-4000], correlated color temperature [CCT] = 4000 K) or Sunlike LED ( n = 12, [SL-4000], CCT = 4000 K; n = 9, [SL-6500], CCT = 6500 K) white lighting environments. Form-deprivation myopia was induced monocularly from day 1 post-hatching (D1) until D14. On D14, form deprivation was halted and the recovery of form-deprived (FD) eyes was monitored until D28. Axial length (AL), refraction, choroidal thickness, and anterior chamber depth were measured in vivo on D1, D7, D14, D22, and D28. Differences in outcome measures between eyes and groups were compared using 2-way repeated-measures ANOVA. Results AL and myopic refraction of FD eyes increased similarly among groups during form-deprivation. FD eyes of animals raised under SL-4000 (D22: P < 0.001 and D28: P < 0.001) and SL-6500 (D22: P = 0.006 and D28: P < 0.001) recovered faster from axial elongation compared with animals raised under FL-4000. The refractive status of FD eyes reared under SL-6500, not under FL-4000 or SL-4000, was similar to control eyes on D28 ( P > 0.05). However, SL-4000 and SL-6500 exhibited similar refraction on D28 than FL-4000 ( P > 0.05). Choroidal thickness was significantly greater in FD eyes of chickens raised under SL-6500 than in animals raised under FL-4000 ( P = 0.03). Conclusions Compared to fluorescent light, moderate intensities of full-spectrum Sunlike LEDs can accelerate recovery from form-deprivation myopia in chickens, potentially through a change in the choroid-mediated pathway.

show abstract

Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Recovery From Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum

Muralidharan

Low

Lee

et al. 2022

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Photodamage by light is affected by various factors, including not only the spectral distribution and illuminance but also the color rendering, irradiance, correlated color temperature, visible light wavelength, and exposure time, among other factors. 63 For example, the relative intensity of red light in the full-spectrum LED has also increased, and the benefits of red light in treating diseases and preventing myopia have been confirmed in many studies. 64 , 65 We will further investigate this aspect in a follow-up study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Spectrum of LEDs on Retinal Degeneration Through Regulating Endoplasmic Reticulum Stress

Chen

Lin

Xiao

et al. 2023

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose To evaluate the impact of full-spectrum light-emitting diodes (LEDs) on albino guinea pigs’ retina and investigate the roles of short-wavelength opsin (S-opsin) and endoplasmic reticulum (ER) stress in light-induced retinal degeneration (LIRD). Methods Three-week-old albino guinea pigs ( n = 30) were distributed into five groups under 12/12 light/dark cycles with indoor natural light (NC; 300–500 lux, n = 6), full-spectrum LEDs (FL; 300 lux, n = 6; 3000 lux, n = 6), and commercial cold-white LEDs (CL; 300 lux, n = 6; 3000 lux, n = 6) and raised for 28 days. Hematoxylin and eosin staining and transmission electron microscopy evaluated the morphological changes of retinas. The immunofluorescence and real-time quantitative polymerase chain reaction (RT-qPCR) measured the expression and content of S-opsin and ER stress-related genes and proteins. Results We found that albino guinea pigs exposed to FL at either 300 lux or 3000 lux developed less severe retinal morphological damage than animals exposed to the CL light, which emerged as a significant characteristic of LIRD. Meanwhile, the damage on the ventral retina was more serious, mainly due to its ability to absorb the blue light in the LEDs more easily. Compared to the FL-exposed groups, the CL light increased the aggregation of S-opsin and the expression of ER stress-related factors. Conclusions Commercial cold-white LEDs can induce ER stress and unfolded protein response in LIRD, and full-spectrum LED attenuates LIRD by regulating ER stress in albino guinea pig retinas in vivo. Translational Relevance Full-spectrum LEDs offer specific eye protection and eye adaptability that can well replace commercial cold-white LEDs in both clinical practice and research. It should be further developed for lighting used in health care facilities.

show abstract

Effects of morning and evening exposures to blue light of varying illuminance on ocular growth rates and ocular rhythms in chicks

Nickla

Rucker

Taylor

et al. 2022

Experimental Eye Research

View full text Add to dashboard Cite

Spectral composition of artificial illuminants and their effect on eye growth in chicks

Cited by 8 publications

References 61 publications

Recovery From Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum

Recovery From Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum

Effects of Different Spectrum of LEDs on Retinal Degeneration Through Regulating Endoplasmic Reticulum Stress

Effects of morning and evening exposures to blue light of varying illuminance on ocular growth rates and ocular rhythms in chicks

Contact Info

Product

Resources

About