Spectral domain optical coherence tomography evaluation of macular changes in Eales disease

Goel, Neha; Kumar, Vinod; Arora, Supriya; Jain, Pooja; Ghosh, Basudeb

doi:10.4103/ijo.ijo_845_17

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…Five studies reported the association between OCT findings and secondary effects in retinal vasculitis [ 28 , 30 , 41 , 42 ]. In the first study, Monnet D et al conducted an analytical cross-sectional study of 80 birdshot chorioretinopathy patients (160 eyes) [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…In a study published in 2018, Goel N et al conducted case series in 79 eyes of 66 patients with Eales disease and active vasculitis [ 42 ]. The study didn’t report any association type of statistics.…”

Section: Resultsmentioning

confidence: 99%

“…The secondary effects of retinal vasculitis on the macula are much easier to observe with OCT. These OCT features include cystoid macule oedema (reported in 3 studies) [ 28 , 30 , 42 ], epiretinal membrane (reported in 4 studies) [ 28 , 30 , 40 , 42 ], and the disruption in the ellipsoid zone (reported in 2 studies) [ 40 , 41 ]. These secondary effects are non-specific so could not be used to diagnose retinal vasculitis.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review of OCT and OCT angiography in retinal vasculitis

Dhirachaikulpanich

Chanthongdee

Zheng

et al. 2023

J Ophthal Inflamm Infect

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Background Retinal vasculitis is a component of uveitis for which the Standardisation of Uveitis Nomenclature (SUN) working group has no standard diagnostic criteria or severity grading. Fluorescein angiography is the gold standard test to assess retinal vasculitis, but is invasive and time-consuming. Optical coherence tomography (OCT) provides non-invasive detailed imaging of retinal structures and abnormalities, including blood vessel architecture and flow with OCT angiography (OCT-A). However, use of OCT in retinal vasculitis beyond assessing macular oedema, is not well established. We conducted a systematic review to understand the features of retinal vasculitis in OCT, Enhanced-depth imaging OCT (OCT-EDI) and OCT-A imaging. Methods The systematic search was done in March 2022 and updated in January 2023, through PubMed, EMBASE and the Web of Science database for studies related to OCT, OCT-EDI and OCT-A findings and retinal vasculitis. Bias assessment was assessed using JBI Critical Appraisal Checklist, and any findings associated with retinal vasculitis were extracted by qualitative analysis. Results We identified 20 studies, including 8 articles on OCT, 6 on OCT-EDI and 6 on OCT-A. The studies included analytical retrospective studies, case-series, and a case–control study. Five OCT studies reported secondary complications could be detected, and four reported retinal thickness alteration in retinal vasculitis. Five studies explored choroidal thickness alteration in OCT-EDI, and four explored capillary density alterations in retinal vasculitis using OCT-A. The heterogeneity in the studies’ analysis and design precluded a meta-analysis. Discussion There were no clear OCT, OCT-EDI or OCT-A findings that demonstrated potential to supersede fluorescein angiography for assessing retinal vasculitis. Some signs of macular structural effects secondary to retinal vasculitis may help prognostication for vision. The OCT signs of inflamed retinal vessels and perivascular tissue is an unexplored area.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of OCT and OCT angiography in retinal vasculitis

Dhirachaikulpanich

Chanthongdee

Zheng

et al. 2023

J Ophthal Inflamm Infect

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“…In addition, macular involvement has been frequently reported in recent studies since the advent of better imaging techniques, but there were not enough study samples. 1,4,25 By pooling all the current evidence, we found that macular changes occur in approximately 24% (95% CI [7%–45%]) of eyes with Eales disease; the most common of which was cystoid macular edema (15%, 95% CI [9%–22%]) and epiretinal membrane (12%, 95% CI [5%–21%]). Other macular changes reported were macular ischemia, internal lining membrane folds, hard educates, and macular holes.…”

Section: Discussionmentioning

confidence: 96%

Clinical Characteristics of Eales Disease and the Efficacy of Different Interventions for Neovascular Complications

Zhao

Cheng

Zhang

et al. 2022

Retina

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Supplemental Digital Content is Available in the Text.Controversies about characteristics of Eales disease and the efficacy of different therapies have lasted for decades. Here, all available studies were analyzed and clarified the epidemiology, etiology, symptoms, clinical manifestations, and complications of Eales disease. In addition, we also made a comprehensive summary of the current treatments for neovascular complications.

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“…Goel ve arkadaşlarının yaptığı bir çalışmada gözlerin %58,2'sinde makülada tutulum saptanmış, en sık nedenin maküla ödemi, ikinci sıklıkta da epiretinal membran olduğu izlenmiştir. [29] Bu olguların tanı ve takibinde OKT yararlı bir yöntemdir.…”

Section: Optik Koherens Tomografiunclassified

Eales Disease

2023

Güncel Retina (Current Retina)

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Eales disease, first described by Henry Eales in 1880, constitutes an idiopathic occlusive retinal vasculopathy apparently multifactorial, and with a likely immunologic origin, which mainly affects the peripheral retina bilaterally in young patients predominantly males. Most cases are asymptomatic in the early stages of the disease however, in the course of the disease floaters and blurry vision arise and hemorrhages lead to significant visual loss. The clinical appearance depends on the peripheral nonperfusion and neovascularization that follow retinal perivasculitis. Visual loss is commonly due to vitreous hemorrhage and tractional retinal detachment. Routine biochemical tests, fundus fluorescein angiography, widefield angiography, optical coherence tomography, optical coherence tomography angiography, and ultrasound are used in the diagnosis of the disease. Corticosteroids, immunosuppressive agents, laser photocoagulation, intravitreal triamcinolone, anti-VEGF injections, and vitrectomy are treatment modalities.

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Spectral domain optical coherence tomography evaluation of macular changes in Eales disease

Cited by 11 publications

References 19 publications

A systematic review of OCT and OCT angiography in retinal vasculitis

A systematic review of OCT and OCT angiography in retinal vasculitis

Clinical Characteristics of Eales Disease and the Efficacy of Different Interventions for Neovascular Complications

Eales Disease

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