We propose and experimentally demonstrate an all-optical Nyquist sinc-shaped pulse train source based on intensity modulation and four-wave mixing. The proposed scheme allows for the tunability of the bandwidth and the full flexibility of the repetition rate in the limit of the electronic bandwidth of the modulators used through the flexible synthesis of rectangular frequency combs. With the ever-growing demand for telecommunication bandwidth, highly efficient spectral techniques are currently thoroughly investigated in order to optimize the capacity of fiber optics networks. Two digital techniques are commonly used: orthogonal-frequency division multiplexing (OFDM), where a superchannel composed of sincshaped subcarriers is generated, and Nyquist-WDM where the data symbols are carried by Nyquist-shaped pulses in the time domain [1]. Recently, the concept of orthogonal time-division multiplexing (O-TDM) of optically generated Nyquist pulses was demonstrated [2]. In this scheme, the ultra-short Nyquist pulses are generated all-optically and time multiplexed with no intersymbol interference (ISI), taking advantage of the orthogonality of Nyquist pulses. Various techniques to generate optical Nyquist pulses have been demonstrated including spectral reshaping of mode-locked laser [2] or fiber optical parametric amplification using one degenerated pump [3] or two dissimilar frequency pumps in order to achieve uniform pulse generation over a wide bandwidth [4]. These techniques allow for the generation of Nyquist pulses of a few picoseconds duration down to sub-picosecond. However, reducing the complexity of these schemes to a viable solution is not straightforward. Moreover, the generated Nyquist pulses exhibit a non-rectangular spectrum, which leads to the necessity of guard band between WDM channels. To overcome these limitations, another technique based on phase-locked flat-comb generation was demonstrated to obtain sinc-shaped pulse trains [5]. The proofof-principle setup was based on intensity modulators driven by radio-frequency (RF) tones. This simple setup is cost-effective, but the generated bandwidth remains limited to three times the electronic bandwidth of the modulators. In order to overcome the bandwidth limitation, we show that a nonlinear stage based on Kerr effect in highly nonlinear fiber (HNLF) can be used to expand the bandwidth of the generated comb while maintaining the high flexibility and reconfigurability advantages of the original technique. The proposed principle for the Nyquist sinc-shaped pulse train generation is sketched in Fig. 1. Three stages of rectangular-shaped in-phase optical frequency comb generators (RI-OFCG's) are used to achieve a Nyquist-sinc pulse train from an initial optical continuous wave (CW) [ Fig. 1(a)]. The first and third stages are based on intensity modulation, while the second stage is based on four-wave mixing (FWM) [6,7] combined with a wavelength selective switch (WSS) [8].At the first RI-OFCG stage, the CW input is modulated via an intensity modulator (IM 1 ...