Spectral studies of oligoribonucleotide-based drugs

Abstract

The biological activity of oligoribonucleotide (ORN) based drugs studied very actively at the same time. However, at the same time, it is of great importance to study their biophysical particularly spectral properties.As the samples, we worked with the "Nuclex", pharmaceutical drugs that are based on a combination of ORN and alcohol sugar D-mannitol (D-M), and the main components of these drugs (active substance -ORN and excipient -D-M). We have measured the UV-Vis absorption, fluorescence, and fluorescence excitation spectra of drugs and their components dissolved in the water under the room temperatures.In the course of our research, we found the autofluorescence centers of Nuklex and identified the possibility of forming complexes between ORN and D-M.

Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus

“…The reason for such improvement in patients prescribed with combination therapy may be a specific antiviral activity of Nuclex, which is based on the mechanisms of influence on the surface antigens and virus receptors conformation, and its anti-inflammatory activity provided by regulation of adenosine Ade1 receptor, normalization of NO-synthetase activity, stabilization of cell membranes and optimization of redox balance in tissues. Ribonucleic acid can also normalize cellular immunity by increasing the migration and cooperation of T-and B-lymphocytes and phagocytic activity of macrophages as well as by enhancing the activity of non-specific resistance factors, that also explains more prominent changes in subpopulations of peripheral blood lymphocytes in our patients with IM using combination therapy compared to patients with IM using basic therapy [24,25].…”