Spectral, thermal and electrochemical characterization of novel homo-dinuclear complexes [M2(H3DTPA)(H2O)6]Cl2·xH2O (M=Cr2+, Mn2+, Co2+, Ni2+ or Cu2+)

Siddiqi, Zafar A.; Noor, Shabana; Shahid, M.; Khalid, Mohd

doi:10.1016/j.saa.2011.01.015

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…The molecule of H 5 DPTA can provide eight potential binding/coordinating centres [37]. Siddiqi [38]. The spectrophotometric data suggest a hexacoordinate distorted octahedral environment around the metal ion.…”

Section: Introductionmentioning

confidence: 99%

Immobilization of His-tagged kinase JAK2 onto the surface of a plasmon resonance gold disc modified with different copper (II) complexes

Kurzątkowska¹,

Mielecki²,

Grzelak³

et al. 2014

Talanta

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New surface plasmon resonance (SPR) sensing platform swhich consists of copper (II) complexes of a pentetic acid thiol ligand (DPTA-Cu(II)) and of a thiol derivative of dipyrromethene (DPM-Cu(II) created on the surface of gold SPR disc were applied to oriented immobilization of His-tagged Janus kinase 2 (GST-His 6 -JAK2). This method is based on the covalent bond formation between histidine from a His-tag chain of a protein and Cu(II) centres from the complexes. The kinetic and thermodynamic parameters of the oriented immobilization of GST-His 6 -JAK2 protein to DPTA-Cu(II) and DPM-Cu(II) complexes attached to the Au surface of a SPR disc were discussed.

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Section: Introductionmentioning

confidence: 99%

Immobilization of His-tagged kinase JAK2 onto the surface of a plasmon resonance gold disc modified with different copper (II) complexes

Kurzątkowska¹,

Mielecki²,

Grzelak³

et al. 2014

Talanta

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Synthesis, structural characterization and evaluation of catalytic and antimicrobial properties of new mononuclear Ag(I), Mn(II), Cu(II) and Pt(IV) complexes

Ali

–Wahab

Ismail

2017

Journal of Molecular Structure

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Pentetic acid (DPTA) Cu(II) monolayer deposited on gold electrode—The base of biosensors for electrochemical screening of kinase JAK2 and potential inhibitor interactions

Wojtasik¹,

Mielecki²,

Kurzątkowska³

et al. 2014

Sensors and Actuators B: Chemical

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Here, the new biosensor destined for screening of interactions between kinase JAK2 and compounds which may act as inhibitors was presented. The Cu(II) complex of pentetic acid thiol ligand was applied for immobilization of kinase JAK2 on the gold electrode surface through his-tagged chemistry. The base of the biosensor response was the change of the electrochemical properties of the Cu(II) redox centres upon formation of the kinase JAK2-potential inhibitor complex. The increasing inhibitor concentration caused the decrease of reduction/oxidation Cu(II) current observed with Osteryoung square wave voltammetry. The biosensor usability was checked using known inhibitors, berberines-isoquinolone alkaloids, as well as caffeic acid-a control compound which has no affinity to kinase JAK2. The possible parameters suitable for estimation of the strength of the interactions between kinase JAK2 covalently attached to the Cu(II) complex of pentetic acid thiol ligand deposited on the gold electrode surface and potential inhibitors present in the solution were presented.

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Spectral, thermal and electrochemical characterization of novel homo-dinuclear complexes [M2(H3DTPA)(H2O)6]Cl2·xH2O (M=Cr2+, Mn2+, Co2+, Ni2+ or Cu2+)

Cited by 6 publications

References 27 publications

Immobilization of His-tagged kinase JAK2 onto the surface of a plasmon resonance gold disc modified with different copper (II) complexes

Immobilization of His-tagged kinase JAK2 onto the surface of a plasmon resonance gold disc modified with different copper (II) complexes

Synthesis, structural characterization and evaluation of catalytic and antimicrobial properties of new mononuclear Ag(I), Mn(II), Cu(II) and Pt(IV) complexes

Pentetic acid (DPTA) Cu(II) monolayer deposited on gold electrode—The base of biosensors for electrochemical screening of kinase JAK2 and potential inhibitor interactions

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