Spectrofluorimetric first derivative synchronous approach for determination of olanzapine and samidorphan used for treatment of schizophrenia in pharmaceutical formulations and human plasma

Salem, Hesham; Samir, Ebtihal; Mazen, Dina Z; Madian, Hoda; Elkhateeb, Alshimaa E.; Elaraby, Manar; Rasekh, Manar I.; Gamal, Aliaa

doi:10.1016/j.saa.2022.121105

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…Several reports have been published for the assay of OLZ, such as LC–MS [ 11 , 12 ], HPLC [ 13 ], GC [ 14 ], electrochemical methods [ 15 , 16 ], spectrophotometry [ 17 , 18 ], and spectrofluorimetry [ 19 , 20 ]. Similarly, several methods for the determination of DZP have been reported, such as LC–MS [ 21 , 22 ], HPLC [ 23 ], GC [ 24 ], electrochemical methods [ 25 ], spectrophotometry [ 26 , 27 ], and spectrofluorimetry [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Nitrogen and sulfur-doped carbon quantum dots as fluorescent nanoprobes for spectrofluorimetric determination of olanzapine and diazepam in biological fluids and dosage forms: application to content uniformity testing

et al. 2022

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A validated, sensitive, and simple spectrofluorimetric method was developed for the analysis of two important CNS-acting drugs, olanzapine and diazepam, in their commercial tablets without the need for any pretreatment steps. The developed method relied on the quantitative quenching effect of each of olanzapine and diazepam on the native fluorescence of nitrogen and sulfur-doped carbon quantum dots (NS@CQDs). NS@CQDs were prepared from thiosemicarbazide and citric acid by a facile one-pot hydrothermal technique. The synthesized NS@CQDs were characterized by different spectroscopic and microscopic techniques. NS@CQDs produced a maximum emission peak at 430 nm using 360 nm as an excitation wavelength. Calibration curves showed a good linear regression over the range of 5.0–200.0 and 1.0–100.0 μM with detection limits of 0.68 and 0.29 μM for olanzapine and diazepam, respectively. The adopted method was used for the determination of the investigated drugs in their tablets with high % recoveries (98.84–101.70%) and low % RSD values (< 2%). As diazepam is one of the most commonly abused benzodiazepines, the developed method was successfully applied for its determination in spiked human plasma with high % recoveries and low % RSD values, providing further insights for monitoring its potential abuse. The quenching mechanism was also studied and confirmed to be through dynamic and static quenching for olanzapine and diazepam, respectively. Due to the high selectivity and sensitivity, content uniformity testing of low-dose tablets was successfully performed by applying the United States Pharmacopoeia guidelines. The method's validation was performed in compliance with ICHQ2 (R1) recommendations.

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Section: Introductionmentioning

confidence: 99%

Nitrogen and sulfur-doped carbon quantum dots as fluorescent nanoprobes for spectrofluorimetric determination of olanzapine and diazepam in biological fluids and dosage forms: application to content uniformity testing

et al. 2022

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Eco-Friendly Synchronous Spectrofluorimetric Determination of Imipenem, Cilastatin, and Relebactam; Application to Market Formulations and Biological Fluids; Greenness Assessment

Salem,

Abdelmajed,

Emad

et al. 2024

J Fluoresc

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The proposed study introduces a rapid, sensitive, and simple synchronous spectrofluorimetric technique for simultaneous quantification of relebactam, cilastatin, and imipenem in marketed pharmaceutical forms and biological fluids. Using synchronous fluorescence spectroscopy at Δ λ = 110 nm, cilastatin was detected at 360 nm. Fourier Self-Deconvolution was subsequently applied to the spectrum to estimate relebactam and imipenem at 430 nm and 470 nm, respectively after detection of cilastatin at 360 nm ensuring no cross-interference. The pH was adjusted to 8.0 using 2.0 mL of alkaline borate buffer. This approach allowed for the precise quantification of relebactam, cilastatin, and imipenem through ranges of 50–400 ng mL− 1, 20–500 ng mL− 1, and 50–500 ng mL− 1 respectively. The lower detection and quantitation limits were 9.9 and 29.7 ng mL− 1 for REL, 4.5 and 13.6 ng mL− 1 for CIL and 5.5 and 16.5 ng mL− 1 for IMP. The proposed method was successfully applied for the determination of studied drugs in their pharmaceutical formulations with a high degree of accuracy and without interference from common excipients. This approach allowed for the precise quantification of relebactam, cilastatin, and imipenem through ranges of 50–400 ng mL− 1, 20–500 ng mL− 1, and 50–500 ng mL− 1, respectively. The proposed method was rigorously validated according to ICH guidelines. Furthermore, the method’s environmental impact was assessed using Eco-scale and Green Analytical Procedure Index (GAPI) techniques.

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Gold nanoparticles assisted colorimetric sensing of paroxetine, duloxetine, and olanzapine in aqueous and micellar systems with improved sensitivity

Laghari,

Khuhawar,

Jahangir

et al. 2024

Microchemical Journal

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Spectrofluorimetric first derivative synchronous approach for determination of olanzapine and samidorphan used for treatment of schizophrenia in pharmaceutical formulations and human plasma

Cited by 5 publications

References 14 publications

Nitrogen and sulfur-doped carbon quantum dots as fluorescent nanoprobes for spectrofluorimetric determination of olanzapine and diazepam in biological fluids and dosage forms: application to content uniformity testing

Nitrogen and sulfur-doped carbon quantum dots as fluorescent nanoprobes for spectrofluorimetric determination of olanzapine and diazepam in biological fluids and dosage forms: application to content uniformity testing

Eco-Friendly Synchronous Spectrofluorimetric Determination of Imipenem, Cilastatin, and Relebactam; Application to Market Formulations and Biological Fluids; Greenness Assessment

Gold nanoparticles assisted colorimetric sensing of paroxetine, duloxetine, and olanzapine in aqueous and micellar systems with improved sensitivity

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