Spectrofluorimetric quantitative analysis of favipiravir, remdesivir and hydroxychloroquine in spiked human plasma

Fluorimetric Determination of Antiviral (COVID-19) Drug Favipiravir in Bulk and Pharmaceutical Dosage Forms

“…Comparative studies of method developed for analyzing Favipiravir in Pharmaceutical preparations using HPLC and UV were also found 15 . Concurrent Fluorescence based analysis of remdesivir and favipiravir 16 , Spectrofluorimetric analysis of Favipiravir, remdesivir and hydroxychloroquine spiked in human plasma 17 are the two methods found for analysis of Favipiravir along with other drugs using Fluorescence. Since there were no reported methods found for individual analysis of Favipiravir using fluorescence, the present method was developed.…”

A validated eco-friendly HPLC-FLD for analysis of the first approved antiviral remdesivir with other potential add-on therapies for COVID-19 in human plasma and pharmaceuticals

“…23 Also, HCQ and LVX have been described as a combination treatment in cutaneous manifestations in patients with COVID-19. Numerous HPLC [25][26][27][28][29][30][31][32][33][34][35] and spectrouorimetric 36 studies have been reported to analyze each cited drug alone or with other drugs. Till now, only two HPLC methods 34,35 and one spectro-uorimetric method 36 have been reported to determine two of the mentioned drugs, RDV and HCQ, together.…”

“…Although the fluorometric method 36 provided a low detection limit for HCQ at a nanogram level, it could not reach its maximum plasma concentration ( C max = 50 ng). 37 Also, it provided a narrow linear range with a high detection limit for RDV.…”

“…Numerous HPLC 25–35 and spectrofluorimetric 36 studies have been reported to analyze each cited drug alone or with other drugs. Till now, only two HPLC methods 34,35 and one spectrofluorimetric method 36 have been reported to determine two of the mentioned drugs, RDV and HCQ, together.…”

Green adherent spectrophotometric determination of molnupiravir based on computational calculations; application to a recently FDA-approved pharmaceutical dosage form

“…Computational chemistry represents an integral approach, in HPLC [4] , [5] , spectrophotometry [6] , [7] and electrochemistry [8] , to the development of greener methods based on theoretical testing of compound interactions and reducing the use of toxic solvents [9] . Many analytical methods have been developed to demonstrate the quality of the drug materials including HPLC [10] , TLC [11] , specroflorimetry [12] , [13] , [14] , [15] , [16] , [17] as well as spectrophotometry [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] . Table 1.…”