Spectrophotometric and polarographic investigation of the Ofloxacin—Cu(II) complexes

Kapetanović, Vera; Milovanović, Lj.; Erceg, M.

doi:10.1016/s0039-9140(96)01999-6

Cited by 33 publications

(17 citation statements)

References 14 publications

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“…However, in spite of their high selectivity and sensitivities, these techniques are time-consuming, require complex sample procedures and involve the use of large amounts of reagents and organic solvents thus incurring in considerable costs. Other alternatives described include spectrophotometric [21][22][23], fluorimetric [24][25][26], chemiluminesce [27][28][29], voltammetric [30][31][32], and immunoassay [33] methodologies. Most of them present several disadvantages such as use of expensive equipment, inadequate selectivity, requirement of long sample pretreatment or even complex treatment of the analytical results.…”

Section: Introductionmentioning

confidence: 99%

Determination of Ofloxacin in Pharmaceuticals, Human Urine and Serum Using a Potentiometric Sensor

et al. 2011

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An ofloxacin-selective electrode was developed for application in pharmaceutical preparations, serum and urine analysis. The electrode is based on tetrakis[3,5-bis(trifluoromethyl)phenyl]borate as ion exchanger in a poly(vinyl chloride) membrane. The sensor displayed a Nernstian response for ofloxacin over a wide concentration range (3 10) with a slope of 55 AE 1 mV per decade of concentration and a practical detection limit of 1 10 À6 mol L À1. The electrode was successfully applied to the determination of ofloxacin in samples with no pretreatment steps, adequate accuracy and precision and recoveries within the intervals of 94-107 %.

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Section: Introductionmentioning

confidence: 99%

Determination of Ofloxacin in Pharmaceuticals, Human Urine and Serum Using a Potentiometric Sensor

et al. 2011

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“…The analytical procedures include atomic absorption spectrometry [3], colorimetry [4], flow injection spectrophotometry [5], spectrophotometry [6][7][8], microbiological assay [9], spectrofluorimetry [10][11][12], liquid chromatography [13][14][15][16][17], chemiluminance [18][19][20][21][22] and electroanalytical techniques [23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

“…OFL was determined by single sweep polarography by measuring reduction peak at 1.55 V vs. SCE in buffer of pH-6 [26]. OFL was also determined polarographically in buffer (pH 4) [27], by DPP in buffer (pH 8.36) at 1.4 V vs. Ag/AgCl over the range 0.01-0.1 mM [28] and by DPP through its complex with copper(II) [29].…”

Section: Introductionmentioning

confidence: 99%

Cathodic stripping voltammetry of pipemidic acid and ofloxacin in pharmaceutical dosages and human urine

Solangi

Mallah

Khuhawar

et al. 2009

JICS

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Sensitive cathodic stripping voltammetric methods have been developed for two quinolone antibacterial drugs, pipemidic acid (PIP) and ofloxacin (OFL) using hanging mercury drop electrode as working electrode vs. Ag/AgCl reference electrode. The methods were developed for the determination of drugs individually as well as simultaneously. 0.1 M and 0.01 M hydrochloric acid was used as medium for PIP and OFL, respectively, 0.1 M potassium chloride was used as base electrolyte. Reduction waves were observed for PIP within -700 mV to -800 mV and for OFL within -1100 mV to -1200 mV. Linear calibration ranges for PIP and OFL were observed within 10-100 µg ml -1 with detection limits of 50 ng ml -1 and 1 µg ml -1 , respectively. Relative standard deviations (RSD) for the analysis of 10 µg ml -1 of PIP and OFL (n = 6) were 0.5% and 1.4%, respectively. The presence of glucose, lactose, sorbitol, gum arabic, starch, magnesium stearate, methylparaben and propylparaben did not affect the determinations of both PIP and OFL. The methods were used for the analysis of pharmaceutical preparations and the results indicated relative deviation of 0.5-5.5% from labeled values with RSD within 0.49-2.5%. PIP and OFL could also be determined simultaneously, and were determined from spiked human urine.

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“…As all quinolone types 15 with antibacterial activity have 4-quinolone nucleus with a nitrogen at position 1, a carboxyl group at position 3, and a ketone at position 4, absorption of orally administered quinolones is significantly decreased when these agents are coadministered with aluminum, magnesium, calcium, iron or zinc, because of the formation [16][17][18][19] On the other hand, quinolone antibiotics complexation with aluminum(III), magnesium(II) and calcium(II) have been studied by spectrophotometry. 35,36 We noticed that an addition of acidic xanthene dyes such as erythrosin (ERY) in the reaction between a quinolone antibiotic and aluminum(III) showed a red shift as compared with that of the ERY-aluminum(III) solution, and that the magnitude of the increase in absorbance of the ERY-aluminum(III) solution was proportional to the concentration of a quinolone antibiotic.…”

mentioning

confidence: 99%

“…As all quinolone types 15 with antibacterial activity have 4-quinolone nucleus with a nitrogen at position 1, a carboxyl group at position 3, and a ketone at position 4, absorption of orally administered quinolones is significantly decreased when these agents are coadministered with aluminum, magnesium, calcium, iron or zinc, because of the formation [16][17][18][19] of insoluble drug cationic chelate compounds in the gastrointestinal tract. Methods for analyzing quinolones include spectrophotometery, [20][21][22] fluorometry, 23,24 chromatography, [25][26][27][28][29] electrophoresis, 30,31 and electroanalysis.…”

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confidence: 99%

Spectrophotometric Determination of Quinolone Antibiotics by an Association Complex Formation with Aluminum(III) and Erythrosin

et al. 2009

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Ternary complexes can be classified into two major categories: a mixed-ligand complex type and an ion-association complex type. The modes of formation of both types of ternary complex, together with improvements in sensitivity and selectivity which accompany their formation, have been extensively discussed [1][2][3][4][5] in the field of inorganic analysis.In one of the methods to increase the determination sensitivity of organic compounds, the binary ion-pair complex formation between an organic dye and an organic compound has often been used. [6][7][8] The method is complicated since it requires an extraction procedure due to the formation of water-insoluble complexes. And the addition of a surfactant or water-miscible organic solvent to avoid to any extraction procedure usually causes decomposition of the ion-pair complex formed, and the organic compound cannot be determined any longer.We have already reported 9-11 some simple and sensitive spectrophotometric methods for the determination of organic compounds by utilizing the ion-association complex formation among an organic compound, an organic dye, and a metal ion.Quinolone antibiotics [12][13][14] have recently attracted much interest, because they exhibit broad-spectrum bactericidal activity, excellent oral bioavalability, good tissue penetration and favorable safety and tolerability profiles. As all quinolone types 15 with antibacterial activity have 4-quinolone nucleus with a nitrogen at position 1, a carboxyl group at position 3, and a ketone at position 4, absorption of orally administered quinolones is significantly decreased when these agents are coadministered with aluminum, magnesium, calcium, iron or zinc, because of the formation [16][17][18][19] On the other hand, quinolone antibiotics complexation with aluminum(III), magnesium(II) and calcium(II) have been studied by spectrophotometry. 35,36 We noticed that an addition of acidic xanthene dyes such as erythrosin (ERY) in the reaction between a quinolone antibiotic and aluminum(III) showed a red shift as compared with that of the ERY-aluminum(III) solution, and that the magnitude of the increase in absorbance of the ERY-aluminum(III) solution was proportional to the concentration of a quinolone antibiotic. A method using ERY-aluminum(III) solution offers the advantages of greater sensitivity as compared with the conventional spectrophotometric methods. 20,21 In this work, a color reaction of quinolones by utilizing an ion-association complex formation among a quinolone, a metal ion and an organic dye was studied in aqueous media, and then suitable conditions for the spectrophotometric determination of quinolones by using aluminum(III) and ERY were established. The proposed method was applied to the assays of these drugs in pharmaceutical preparations. ExperimentalReagents, solutions and apparatus Reagents and solutions. Ofloxicin (OFX) and other quinolone antibiotics (norfloxacin, enoxacin and levoxacin), analyticalgrade reagents, were purchased from Sigma-Aldrich Co., and used without further...

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Spectrophotometric and polarographic investigation of the Ofloxacin—Cu(II) complexes

Cited by 33 publications

References 14 publications

Determination of Ofloxacin in Pharmaceuticals, Human Urine and Serum Using a Potentiometric Sensor

Determination of Ofloxacin in Pharmaceuticals, Human Urine and Serum Using a Potentiometric Sensor

Cathodic stripping voltammetry of pipemidic acid and ofloxacin in pharmaceutical dosages and human urine

Spectrophotometric Determination of Quinolone Antibiotics by an Association Complex Formation with Aluminum(III) and Erythrosin

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