Spectrophotometric and tandem mass spectroscopic analysis of Indian borage (Plectranthus amboinicus (Lour.) Spreng.) for its polyphenolics characterization

Sulaiman, C T; Deepak, M; Balachandran, Indira

doi:10.1016/j.bjbas.2018.04.004

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…The ethanol-hexane extract exhibited the highest total flavonoids content (96.30 mg QE/g), in which the water extract was the lowest one (9.27 mg QE/g) ( Figure 4). The total flavonoids content in this study was higher than ethanol extract (8.85 mg QE/g), acetone extract (6.50 mg QE/g), and butanol extract (2.56 mg QE/g) of India torbangun leaves from previously reported (Sulaiman, Deepak, & Balachandran, 2018).…”

Section: Total Flavonoids Contentcontrasting

confidence: 63%

Optimization of Total Flavonoids Extraction and Α-Glucosidase Inhibitory Activity from Plectranthus amboinicus (Lour.) Spreng. Leaves using the Simplex-Centroid Design

Wibisono

Aisyah

Suhesti

et al. 2019

Molekul

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The leaves of Plectranthus amboinicus (Lour.) Spreng. (Lamiaceae) is a perennial plant that contained flavonoids compounds with have antidiabetic properties. The aim of the work was to select the best solvent for extraction of the flavonoid compounds from torbangun leaves. A statistical simplex-centroid mixture design for the water, ethanol, and hexane solvents has been used to the extraction of extract yield, flavonoids content, and inhibitory α-glucosidase activity of torbangun leaves. The ethanol-water extracts showed the highest extract yield with value of 15.92%. The ethanol-hexane extracts presented the highest total flavonoids content, 96.30 mg QE/g, followed by hexane extract (82.91 mg QE/g). The ethanol extract recorded higher inhibitory of α-glucosidase activity, with value of 25.53%, followed by hexane extract (25.21%), and ethanol-water extract (23.02%). The weak correlation between the α-glucosidase inhibition and total flavonoids content showed that flavonoids contribute non-significantly to the α-glucosidase activity.

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Section: Total Flavonoids Contentcontrasting

confidence: 63%

Optimization of Total Flavonoids Extraction and Α-Glucosidase Inhibitory Activity from Plectranthus amboinicus (Lour.) Spreng. Leaves using the Simplex-Centroid Design

Wibisono

Aisyah

Suhesti

et al. 2019

Molekul

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“…Liquid chromatography-mass spectroscopic analysis (18) was performed with Agilent 6520 accurate mass Quadrupole -Time of Flight (Q-TOF-LC/MS) attached with Agilent LC 1200 outfitted with Extend C-18 column of 1.8 µm, 2.1 × 50 mm size. Gradient elution was carried out with methanol (A) and 0.1 % acetic acid (B) in the ratio of 70:30 at a constant flow rate of 0.8 ml/min.…”

Section: Lc-esi-ms/ms Analysismentioning

confidence: 99%

LCMS/MS analysis and evaluation of anti-inflammatory and antioxidant activities of the polyphenol fraction of Litsea quinqueflora (Dennst.) Suresh

Jose¹,

Anilkumar²

2021

Plant Sci. Today

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The main aim of the work was to scientifically prove the anti-inflammatory property of the polyphenol-rich fraction of hydro-alcoholic leaf extract of Litsea quinqueflora (Dennst.) Suresh by protein denaturation and free radical scavenging activity. The polyphenol-rich fraction of hydro-alcoholic leaf extract was obtained via acid-alkali hydrolysis, followed by fractionation with chloroform and ethyl acetate. HPTLC profiling of the finally obtained ethyl acetate fraction and consequent derivatisation with aluminium chloride revealed the presence of flavonoids in a more purified form. LCMS/MS analysis tentatively identified the presence of bioactive polyphenolic compounds such as gallocatechin, sinapic acid, pinocembrin, paeonol and umbelliferone in the separated fraction. The polyphenol-rich fraction of hydro-alcoholic extract of leaves showed anti-denaturing activity in heat-induced bovine serum albumin denaturation with an IC50 value of 23.59 µg/ml and was statistically significant at 0.1% level. The antioxidant property of the polyphenol-rich fraction determined by its free radical scavenging ability against DPPH and ABTS showed IC50 values 122.98 and 135.44 µg/ml respectively and was also statistically significant at 0.1% level. Hence, the traditional use of Litsea quinqueflora as an anti-inflammatory agent can be attributed to the presence of polyphenols.

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“…Metode ekstraksi dengan pemanasan menunjukkan adanya senyawa yang terdeteksi dalam Coleus amboinicus (Lour.) yang lebih banyak seperti pada metode decocta (Shubha & Bhatt, 2015;Pane et al, 2018) dan soxhletasi (Mathalaimuthu et al, 2017;Sulaiman et al, 2018). Hal ini dikaitkan dengan efektivitas ekstraksi pada suhu tinggi yang akan meningkatkan solubilitas dan laju difusi analit ke dalam pelarut.…”

Section: Metode Ekstraksiunclassified

“…Variasi dalam penggunaan metode ekstraksi, pelarut, bagian tanaman serta metode analisis yang digunakan dapat berpengaruh terhadap profil fitokimia dan jenis senyawa yang berhasil teridentifikasi (Tabel 1). Sulaiman et al (2018) mengkarakterisasi senyawa polifenol dari daun C. amboinicus (Lour.) dan melaporkan kadar total fenolik, flavonoid dan tanin yang paling tinggi terdapat pada ekstrak etanol, dibandingkan dengan ekstrak aseton dan n-butanol.…”

Section: Fitokimiaunclassified

Review: Profil Fitokimia dan Multipotensi dari Coleus amboinicus (Lour.)

Rahmawati

Astuti

Wahyuono

2021

J. Pharm. Sci. Clin. Res.

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Coleus amboinicus (Lour.) merupakan tanaman obat tradisional yang banyak digunakan oleh masyarakat dan telah diteliti secara ekstensif serta dilaporkan di beberapa bidang ilmu pengetahuan. Penulisan review artikel ini didasarkan pada studi literatur tahun 1993 hingga tahun 2021, yang diperoleh dari database google scholar, Scopus, Science Direct, PubMed, dan lainnya. Tanaman ini merupakan tanaman semak aromatis, berbunga, namun jarang berbiji dan dapat diperbanyak secara vegetatif. Profil senyawa fitokimianya dapat digolongkan menjadi beberapa kelas yang berbeda seperti terpenoid, fenolik, flavonoid, alkaloid, saponin, steroid dan tanin. Tanaman C. amboinicus (Lour.) kaya akan komponen fenolik seperti asam rosmarinat dan asam kafeat, dengan mayoritas komponen volatil utamanya yaitu karvakrol. Profil fitokimia C. amboinicus (Lour.) dapat bervariasi tergantung pada berbagai faktor, seperti lingkungan, keanekaragaman genetik, bagian tanaman yang digunakan, maupun metode dan proses ekstraksi. Potensi farmakologinya seperti antibakteri, antifungi, antioksidan, antikanker, antiinflamasi, antidiabetes, antihiperlipidemia, antimalaria serta laktagoga telah banyak dilaporkan. Selain itu, tanaman ini juga dimanfaatkan dalam kuliner serta sintesis biogenik senyawa nanopartikel. Eksplorasi dari tanaman C. amboinicus (Lour.) juga merambah kepada mikroorganisme endofitnya, dan dikaitkan dengan kemampuannya untuk menghasilkan senyawa bioaktif yang potensial sebagai antibakteri, agen biokontrol serta produksi enzim selulase. Review artikel ini memberikan informasi terkait botani, fitokimia, farmakologi, sintesis biogenik, pemanfaatan lainnya serta eksplorasi mikroorganisme endofitnya. Artikel ini diharapkan dapat menjadi sumber informasi untuk pengembangan potensi C. amboinicus (Lour.) yang semakin meluas.

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Spectrophotometric and tandem mass spectroscopic analysis of Indian borage (Plectranthus amboinicus (Lour.) Spreng.) for its polyphenolics characterization

Cited by 8 publications

References 18 publications

Optimization of Total Flavonoids Extraction and Α-Glucosidase Inhibitory Activity from Plectranthus amboinicus (Lour.) Spreng. Leaves using the Simplex-Centroid Design

Optimization of Total Flavonoids Extraction and Α-Glucosidase Inhibitory Activity from Plectranthus amboinicus (Lour.) Spreng. Leaves using the Simplex-Centroid Design

LCMS/MS analysis and evaluation of anti-inflammatory and antioxidant activities of the polyphenol fraction of Litsea quinqueflora (Dennst.) Suresh

Review: Profil Fitokimia dan Multipotensi dari Coleus amboinicus (Lour.)

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