Spectrophotometric Assay of Certain Cardiovascular Drugs Through Charge Transfer Reactions

Elsayed, M. Abdel-Hady; Barary, Magda H.; Abdel-Salam, Mohamed; Mohamed, S. M.

doi:10.1080/00032718908051203

Cited by 21 publications

(6 citation statements)

References 17 publications

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“…It is superior to other existing spectrophotometric methods 13,14,15 as it provides a wide linear dynamic range of determination. However, the demerit of this method is that it requires heating for 18 min to develop the color.…”

Section: Discussionmentioning

confidence: 98%

“…A review of literature revealed that few spectrophotometric methods for the assay of verapamil hydrochloride based on charge transfer complexes with 2,3,5,6-tetrachloro-p-benzoquinone, 13 2,3-dichloro-5,6-dicyano p-benzoquinone and 2,5-dichloro-3,6-dihydroxy-p-benzoquinone, 14 chromotrope 2B and chromotrope 2R azodyes, 15 extractable ion-pair complexes with bromothymol blue, bromophenol blue, bromocresol green, bromocresol purple and methyl orange. 16 However, a simple spectrophotometric procedure based on the reaction of the drug with an oxidant is not known.…”

Section: Verapamil Hydrochloride Ie (±)-5-[n-mentioning

confidence: 99%

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Rahman¹,

Khan²,

Azmi³

2005

ScienceAsia

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Two spectrophotometric methods have been described for the assay of verapamil hydrochloride in drug formulations. Method A is based on the oxidation of the drug with potassium metaperiodate in sulfuric acid medium to give colored product, which absorbs maximally at 425 nm. Method B involves the formation of colored chloroform extractable ion-pair complex of the drug with tropaeolin 000 No.1 at pH 4.0 showing absorption peak at 400 nm. Under the optimized experimental conditions, Beer' s law is obeyed in the concentration ranges of 12.5-187.5 and 2.0-30.0 µg mL -1 for methods A and B, respectively. Results of analyses were validated statistically and through recovery studies. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. Both methods have been successfully applied to the determination of verapamil hydrochloride in drug formulations.

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Section: Discussionmentioning

confidence: 98%

Section: Verapamil Hydrochloride Ie (±)-5-[n-mentioning

confidence: 99%

Untitled

Rahman¹,

Khan²,

Azmi³

2005

ScienceAsia

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“…Satisfactory results ( Table 2) were obtained for the recovery of drug and were in a good agreement with the label claim. The results of the proposed method were statistically compared with those obtained by the reference method [22]. The calculated Student's t-and F-values were less than the theoretical values for 95% confidence level.…”

Section: Analytical Datamentioning

confidence: 89%

“…The visible spectrophotometric methods are the instrumental methods of choice and have practical and significant economic advantages over the other methods. In the literature few spectrophotometric methods have been reported; these are usually based either on extractable ion-pair complex formation with bromophenol blue, bromocresol purple, bromocresol green, bromothymol blue and methyl orange [17]; solochrome black-T, solochrome dark blue, solochrome cyanine R and fast sulfone FF [18]; eriogloucine and indigocarmine [19]; alizarin red-S [20] or on charge-transfer complex formation with polyhalo-or polycyanoquinones [21,22] and azo dyes [23]. Some of these methods, however, suffer from disadvantages such as low sensitivity, lack of selectivity, and complexity.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant.

Rahman

Hoda

2002

Analytical and Bioanalytical Chemistry

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A new spectrophotometric method is described for the determination of verapamil hydrochloride, based on its oxidation with chloramine-T in hydrochloric acid medium. It produces a yellow colored compound with maximum absorbance at 425 nm. Beer's law was obeyed in the concentration range 0-340 micro g mL(-1) with molar absorptivity 2 x 10(3) L mol(-1) cm(-1) and RSD 0.3-0.82%. All variables were studied to optimize the reaction conditions. No interferences were observed from the common excipients present in the formulations. The method has been applied successfully to the determination of the drug in pharmaceutical preparations. Statistical comparison of the results with those from the reference method reveals excellent agreement and confirms that accuracy and precision are not significantly different.

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“…51050] by NBS. Even though a few methods are available for the spectrophotometric estimation of TTC [9][10][11][12][13], [14][15][16], EA [17][18][19][20] and INH [21][22][23][24][25], we could find no report of spectrophotometric methods for the determination of NIF in the literature.…”

mentioning

confidence: 99%

Spectrophotometric determination of drugs in pharmaceutical formulations withN-bromosuccinimide and celestine blue

1996

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Abstract. Simple, sensitive and selective methods are proposed for the spectrophotometric determination of drugs, viz., tetracycline HC1, nifurtimox, ethionamide, propranolol HC1 and isonicotinic acid hydrazide, based on their reactivity with N-bromosuccinimide (NBS). The method involves the addition of excess NBS of known concentration in the presence of 0.25 M HC1 and the unreacted NBS is determined by the measurement of the decrease in the absorbance of the dye celestine blue (2m,x 540 rim), which was found to be the most suitable of several dyes tested. This method was applied for the determination of drug contents in pharamaceutical formulations and enabled the determination of the drugs in microgram quantities (0.2 to 5 gg/ml). Standard deviations were typically ~<0.5mg per dose (RSD 0.1-1.0%). No interferences were observed from excipients and the validity of the method was tested against reference method. Recoveries were 99.8-101.1%.

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Spectrophotometric Assay of Certain Cardiovascular Drugs Through Charge Transfer Reactions

Cited by 21 publications

References 17 publications

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Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant.

Spectrophotometric determination of drugs in pharmaceutical formulations withN-bromosuccinimide and celestine blue

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