Spectrophotometric determination of 4-aminoantipyrine in aqueous solution by coupling with diazotised 4-nitroaniline

Al-Abachi, Mouayed Q.; Al-Delami, A. M. S.; Al-Najafi, S.

doi:10.1039/an9881301661

Cited by 7 publications

(3 citation statements)

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“…Oxidative coupling reaction has been used in determination of paracetamol based in reaction with o-cresol (7), or p-xylenol after hydrolysis to p-aminophenol (8) with an oxidizing agent such as sodium periodate.…”

Section: Paracetamolmentioning

confidence: 99%

Spectrophotometric Assay of Paracetamol in Pharmaceutical Preparations

Othman¹,

Zakaria²

2007

J.Edu.Sci.

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‫ال‬ ‫ملخص‬ ‫لت‬ ‫طيفية‬ ‫يقة‬ ‫طر‬ ‫البحث‬ ‫يتضمن‬ ‫قدير‬ ‫اسيتامول‬ ‫البار‬ ‫من‬ ‫الصغر‬ ‫في‬ ‫متناهيه‬ ‫كميات‬ . ‫تعتمد‬ ‫أزوتة‬ ‫عمى‬ ‫يقة‬ ‫الطر‬ ‫ا‬ ‫بار‬ -‫بمفاعمته‬ ‫وذلك‬ ‫اسيتامول‬ ‫لمبار‬ ‫الحامضي‬ ‫التحمل‬ ‫من‬ ‫الناتج‬ ‫فينول‬ ‫امينو‬ ‫يك‬ ‫الهيدروكمور‬ ‫حامض‬ ‫بوجود‬ ‫يت‬ ‫النتر‬ ‫ايون‬ ‫مع‬ ‫ان‬ ‫اقتر‬ ‫ثم‬ ‫قاعدي‬ ‫وسط‬ ‫في‬ ‫الناتج‬ ‫الدايازونيوم‬ ‫ممح‬ ‫مع‬ ‫ان‬ ‫االقتر‬ ‫كاشف‬ ‫اسيتوفي‬ ‫فمورو‬ ‫نون‬ ‫صبغة‬ ‫لتكوين‬ ‫آزوية‬ ‫الماء‬ ‫في‬ ‫وذائبة‬ ‫ة‬ ‫مستقر‬ ‫تقالية‬ ‫بر‬ ‫و‬ ‫تم‬ ‫ل‬ ‫االمتصاص‬ ‫شدة‬ ‫قياس‬ ‫لصبغة‬ ‫الناتجة‬ ‫الموجي‬ ‫الطول‬ ‫عند‬ 472 ‫نانوميتر‬ ‫وكانت‬ ‫حدود‬ ‫قانون‬ ‫التركيز‬ ‫مدى‬ ‫في‬ ‫بير‬ ‫من‬ 10 ‫إلى‬ 180 ‫ام‬ ‫مايكروغر‬ ‫ـ‬ ‫ال‬ ‫من‬ ‫اسيتامول‬ ‫بار‬ / 25 ‫مل‬ ‫قيمة‬ ‫وكانت‬ ‫ية‬ ‫الر‬ ‫المو‬ ‫االمتصاصية‬ ‫هي‬ 2.16  10 4 ‫لتر‬ . ‫م‬ ‫ول‬ -1 . ‫سم‬ -1 ‫النسبي‬ ‫الخطأ‬ ‫و‬ ، ‫اوح‬ ‫تر‬ ‫بين‬ -0.64 ‫و‬ +1.64 % ‫بين‬ ‫النسبي‬ ‫القياسي‬ ‫اف‬ ‫االنحر‬ ‫و‬  0.4 ‫و‬ 1.24 % ‫اعتمادا‬ ‫عمى‬ ‫تركيز‬ ‫مستوى‬ ‫ـ‬ ‫ال‬ ‫اسيتامول‬ ‫بار‬ . ‫تقدير‬ ‫في‬ ‫بنجاح‬ ‫يقة‬ ‫الطر‬ ‫تطبيق‬ ‫تم‬ ‫ـ‬ ‫ال‬ ‫اسيتامول‬ ‫بار‬ ‫في‬ ‫ات‬ ‫المستحضر‬ ‫الصيدالني‬ ‫ة‬ . ABSTRACTA spectrophotometric method for the assay of micro amounts of paracetamol has been developed. The method is based on the reaction of p-aminophenol which results from the acid hydrolysis of paracetamol, with nitrite ion to form the corresponding diazonium salt followed by coupling reaction in an alkaline medium with phloroacetophenone to form a stable and soluble orange azo dye. The intensity of absorbance for the resulting azo dye is measured at 472 nm and Beer's law is obeyed in the concentration range of 10-180 g of paracetamol in a final volume of 25 ml, with a molar absorptivity of 2.1610 4 l.mol -1 .cm -1 , a relative error of -0.64 to +1.64% and a relative standard deviation of 0.4 to 1.24 %, depending on the concentration level of paracetamol. The method has been successfully applied to the assay of paracetamol in various pharmaceutical preparations.

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Section: Paracetamolmentioning

confidence: 99%

Spectrophotometric Assay of Paracetamol in Pharmaceutical Preparations

Othman¹,

Zakaria²

2007

J.Edu.Sci.

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“…Various methods have been reported for the determination of SBS, these include spectrophotometric [2], high performance liquid chromatography [3][4][5], liquid chromatography-tandem mass spectrometry [6], gas chromatography mass spectrometry [7], flow injection analysis [8],and polarographic [9]. Various methods based on diazotization and coupling reactions have been developed for the determination of drugs such as aminoantipyrin [10], sulphonamide [11] and dopamine [12].…”

Section: Introductionmentioning

confidence: 99%

Developed Spectophotometric Determination of Salbutamol Sulphate in Pharmaceutical Samples by Coupling With Diazotized 4-Aminoacetophenone

Al-Abachi¹,

Hammza²

2008

JNUS

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“…To date this has been achieved by two different techniques. The first uses double tagged D°D° events [1], and the second uses D° mesons produced in D*+ -» D°TT + decays [2,3]. Once the total number of D° mesons is known, by reconstructing the D° in the decay mode of interest, one can determine the absolute branching fraction for that channel.…”

mentioning

confidence: 99%

Measurement of the absolute branching fraction forD0→K−
Akerib¹,
Barish²,
Chadha³
et al. 1993
Phys. Rev. Lett.
37
0
3
0
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Using 1.79 fb _1 of data recorded by the CLEO II detector we have measured the absolute branching fraction for D° -• K~w + . The angular correlation between the 7r + emitted in the decay D* + -• L>°7r + , and the jet direction in e + e~ -• cc events, is used to determine the total number of inclusive D° mesons produced from this source. The subsequent reconstruction of the decay chain D* + -> D°ir + , D° -• K~ir~*~ allows a measurement of the absolute D° -• K~TT~*~ branching fraction. Correcting for decay radiation in the final state, we find J3(D° -• K~n + ) = [3.95 ± 0.08(stat)±0.17(syst)]%.

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Spectrophotometric determination of 4-aminoantipyrine in aqueous solution by coupling with diazotised 4-nitroaniline

Cited by 7 publications

References 0 publications

Spectrophotometric Assay of Paracetamol in Pharmaceutical Preparations

Spectrophotometric Assay of Paracetamol in Pharmaceutical Preparations

Developed Spectophotometric Determination of Salbutamol Sulphate in Pharmaceutical Samples by Coupling With Diazotized 4-Aminoacetophenone

Measurement of the absolute branching fraction forD0→K−
Akerib¹,
Barish²,
Chadha³
et al. 1993
Phys. Rev. Lett.
37
0
3
0
View full text Add to dashboard Cite

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Spectrophotometric determination of 4-aminoantipyrine in aqueous solution by coupling with diazotised 4-nitroaniline

Cited by 7 publications

References 0 publications

Spectrophotometric Assay of Paracetamol in Pharmaceutical Preparations

Spectrophotometric Assay of Paracetamol in Pharmaceutical Preparations

Developed Spectophotometric Determination of Salbutamol Sulphate in Pharmaceutical Samples by Coupling With Diazotized 4-Aminoacetophenone

Measurement of the absolute branching fraction forD0→K−Akerib1, Barish2, Chadha3 et al. 1993Phys. Rev. Lett.37030View full textAdd to dashboardCite

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Measurement of the absolute branching fraction forD0→K−
Akerib¹,
Barish²,
Chadha³
et al. 1993
Phys. Rev. Lett.
37
0
3
0
View full text Add to dashboard Cite