2012
DOI: 10.37285/ijpsn.2011.4.4.7
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Spectrophotometric Determination of Alendronate Sodium by using Sodium-1,2-Naphthoquinone-4-Sulphonate

Abstract: A simple, precise and accurate spectrophotometric method was developed for analysis of the osteoporesis drug alendronate sodium (ALS). The method is based on reaction of the drug with sodium-1,2-naphthoquinone-4-sulphonate (NQS) in presence of alkali to form a brown colored complex giving absorption maximum at 525 nm. The drug obeyed Beer’s law in the range of 5-70 µg/ml with a correlation coefficient of 0.999. The LOD and LOQ values are 1.7 µg/ml and 5.0 µg/ml, respectively. The average recoveries for recover… Show more

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Cited by 2 publications
(2 citation statements)
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“…Table 4 presents a comparison between our proposed methods and the other reported ones for the determination of ALN in pharmaceutical dosage forms. This comparison reveals that the proposed spectrofluorimetric method (method II) shows comparable [ 19 , 21 ] or better sensitivity [ 6 9 , 11 14 , 16 , 20 ] to other derivatization methods reported in literature with several advantages, such as being simple and rapid methods with no need for tedious and elaborate steps (heating, centrifugation or waiting time). On the other hand, the proposed HPLC method (method I) is the first reported method for the separation of ALN and its related impurity ABA at the pharmacopeial limit.…”
Section: Resultsmentioning
confidence: 79%
“…Table 4 presents a comparison between our proposed methods and the other reported ones for the determination of ALN in pharmaceutical dosage forms. This comparison reveals that the proposed spectrofluorimetric method (method II) shows comparable [ 19 , 21 ] or better sensitivity [ 6 9 , 11 14 , 16 , 20 ] to other derivatization methods reported in literature with several advantages, such as being simple and rapid methods with no need for tedious and elaborate steps (heating, centrifugation or waiting time). On the other hand, the proposed HPLC method (method I) is the first reported method for the separation of ALN and its related impurity ABA at the pharmacopeial limit.…”
Section: Resultsmentioning
confidence: 79%
“…Spectrophotometric methods were reported for the assay of ALN. [4][5][6][7][8][9][10][11][12][13][14] However, the proposed method has limits of detection and quantitation that are considerably lower than those of many other published methods. [5][6][7]12,13 Moreover, some of the mentioned spectrophotometric methods have a narrow linear dynamic range when compared to the proposed method.…”
Section: Introductionmentioning
confidence: 99%