Spectrophotometric Determination of Amlodipine Besylate in Pure Form and Pharmaceutical Formulation using Amido Black

Al-Khalil, Raghad; Attal, Aya; Sakur, Amir Alhaj

doi:10.5958/0974-360x.2019.00572.9

Rese. Jour. of Pharm. and Technol.

2019

DOI: 10.5958/0974-360x.2019.00572.9

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Spectrophotometric Determination of Amlodipine Besylate in Pure Form and Pharmaceutical Formulation using Amido Black

Raghad Al-Khalil

Aya Attal

Amir Alhaj Sakur

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A Comprehensive Review of Drugs Determined by Spectrophotometry using Vanillin as a Chromogenic Reagent in the Past Decade

Naraparaju,

Barla,

Chaganti

et al. 2024

CPA

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Many analytical techniques have been used in quality control, such as spectrophotometry, spectrofluorimetry, HPLC, and other hyphenated techniques. Among them, spectrophotometry is considered to be one of the most commonly used simple techniques. Drugs that lack chromogenic groups can be readily determined by using the chromogenic reagents, which react with the functional groups present in the drugs and produce a chromogenic group that can be detected in the visible region using a spectrophotometer. Chromogenic reagents play a vital role in the estimation of such types of drugs. Vanillin is one of the chromogenic reagents that possess a carbonyl group that reacts with the drugs that possess amine moiety and results in the formation of Schiff’s base, which is a yellow-colored compound that can be detected by spectrophotometry. The present review gives insights into the reaction conditions and applications of the drugs that are estimated by using vanillin as a chromogenic label.

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A Comprehensive Review of Drugs Determined by Spectrophotometry using Vanillin as a Chromogenic Reagent in the Past Decade

Naraparaju,

Barla,

Chaganti

et al. 2024

CPA

View full text Add to dashboard Cite

show abstract

Stability Indicating HPTLC Method for Simultaneous Determination of Amlodipine Besylate and Lisinopril in Combined Dose Tablet Formulation

Wankhede¹,

Khobragade

Lote

et al. 2021

RJPT

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A combined dose tablet formulation containing Amlodipine besylate and Lisinopril is used for the treatment of essential hypertension. The present study reports development and validation of stability indicating high performance thin layer chromatographic method for simultaneous estimation of these drugs in combined dose tablet formulation. The two drugs were satisfactorily resolved on aluminum plates precoated with silica gel 60F254 using n-butanol : methanol: ammonia (4:4:1 v/v/v) as mobile phase. The Rf value for lisinopril and amlodipine besylate were 0.27±0.02 and 0.62±0.02, respectively. Densitometric evaluation of the separated bands was performed at 215nm. The calibration curves for lisinopril and amlodipine besylate were found to be linear in the concentration range of 1000-6000ng/band. The method was validated as per ICH guidelines for accuracy, precision, robustness, specificity, limit of detection and limit of quantitation. Statistical analysis proves that the method is suitable for simultaneous analysis of Lisinopril and Amlodipine besylate in pharmaceutical formulation without any interference from the excipients/degradant. The developed method offers several advantages such as sensitive, rapid, cost effective and less time consuming as compared to the reported methods. As the method could effectively separate the drugs from its degradation products, it can be employed as a stability indicating method.

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Spectrophotometric Determination of Amlodipine Besylate in Pure Form and Pharmaceutical Formulation using Amido Black

Cited by 2 publications

References 0 publications

A Comprehensive Review of Drugs Determined by Spectrophotometry using Vanillin as a Chromogenic Reagent in the Past Decade

A Comprehensive Review of Drugs Determined by Spectrophotometry using Vanillin as a Chromogenic Reagent in the Past Decade

Stability Indicating HPTLC Method for Simultaneous Determination of Amlodipine Besylate and Lisinopril in Combined Dose Tablet Formulation

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