Spectrophotometric determination of azathioprine in pharmaceutical formulations

Lakshmi, C. Vijaya; Reddy, M. N.

doi:10.1016/s0039-9140(98)00216-1

Cited by 30 publications

(13 citation statements)

References 8 publications

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“…13 The reaction shown in Figure 3 depicts the proposed analytical procedure. The spectrophotometric monitoring of either the consumed nitrous acid (HNO 2 ) with cresyl fast violet acetate or by coupling reaction of the diazonium salt formed with N-1naphthylethylenediamine dihydrochloride has been proposed.…”

Section: Azo Dye Derivatizationmentioning

confidence: 99%

Spectrophotometry: Pharmaceutical Applications

Calatayud

2013

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

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Section: Azo Dye Derivatizationmentioning

confidence: 99%

Spectrophotometry: Pharmaceutical Applications

Calatayud

2013

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

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“…: NBS, being the most versatile, has been used for the spectrophotometric determination of different drugs (26)(27)(28)(29) . These methods involves two stages oxidation of the drug by NBS and the estimation of unconsumed NBS with Celestine blue (CB).…”

Section: Cefprozilmentioning

confidence: 99%

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

2010

Egypt. J. Chem.

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WO SIMPLE, accurate spectrophotometric and potentiometric m methods were developed for the determination of cefprozil, dropropizine and tizanidine hydrochloride in their pharmaceutical preparations. The spectrophotometric method is based on the selective oxidation of cefprozil or tizanidine with N-bromosuccinimide in an alkaline medium to give an intense yellow product with a maximum absorption at 396 or 384 nm, respectively. The reaction conditions were studied and optimized. The reaction obeyed Beer's law over the concentration range 5-40 and 10-80 g ml -1 for cefprozil and tizanidine hydrochloride, respectively. The potentiometric method involves the direct titration of cefprozil and dropropizine with Nbromosuccinimide in sulphuric acid medium and the end point is determined potentiometrically using platinum electrode. Cefprozil and dropropizine can be determined quantitatively in the concentration range of 0.13-1.30 and 0.118-1.180 mg with recovery values of 98.46-100.77 and 99.58-100.85% and relative standard deviations 0.39-0.54 and 0.52-0.87% for cefprozil and dropropizine, respectively. The proposed methods are applied for the determination of these drugs in pure forms and in pharmaceutical preparations.

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“…Several analytical methods such as spectrophotom etry [20,21], HPLC [22,23], titrimetry [24], and H NMR [25] have been reported for the determina tion of AZT in body fluids. However, these methods suffer from some disadvantages such as high costs, long analysis times, low sensitivity and selectivity and requirement for complex and tedious sample pretreat ment.…”

mentioning

confidence: 99%

Voltammetric determination of immunosuppressive agent, azathioprine, by using a graphene-chitosan modified-glassy carbon electrode

Hatami

Jalali

2015

Russ J Electrochem

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Electrodeposition of graphene-chitosan (GR-CS) composite onto glassy carbon electrode was done via a simple one step strategy. Different methods were used for surface characterization which con firmed the presence of a nano structure of graphene sheets. The modified electrode was highly efficient in azathioprine analysis by square wave voltammetry. Reversibility of the redox couple of azathioprine was sig nificantly improved at the surface of GR-CS modified electrode compared to the bare electrode. A linear range of 1.0 × 10 -7 to 2.6 × 10 -5 M of azathioprine was obtained with a sensitivity of 5.54 A/M and a detection limit of 4.7 × 10 -8 M. The proposed sensor exhibited high reproducibility (RSD % = 5%) and repeatability (RSD % = 3.5%) and long term storage stability. The modified electrode was applied successfully to the accurate determination of azathioprine in pharmaceutical and blood serum samples.

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Spectrophotometric determination of azathioprine in pharmaceutical formulations

Cited by 30 publications

References 8 publications

Spectrophotometry: Pharmaceutical Applications

Spectrophotometry: Pharmaceutical Applications

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

Voltammetric determination of immunosuppressive agent, azathioprine, by using a graphene-chitosan modified-glassy carbon electrode

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