Spectrophotometric determination of ceterizine hydrochloride with Alizarin Red S

Basavaiah, K.; Srilatha,; Swamy, Javarappa Manjunatha

doi:10.1016/s0039-9140(99)00179-4

Cited by 28 publications

(15 citation statements)

References 10 publications

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“…A high-performance liquid chromatography (HPLC) with ultraviolet detection (UV) is the most widely used technique (Macek et al, 1999;Choi et al, 2000a, b;Kim et al, 2005;Zaater et al, 2000;Moncrieff, 1992;Jelinska et al, 2000Jelinska et al, , 2001Paw et al, 2002;Arayne et al, 2005;Bajerski et al, 2005;El Walily et al, 1998;Jaber et al, 2004;Nagaralli et al, 2003;Likar et al, 2005;Rosseel and Lefebvre, 1991) or liquid chromatography with spectrometric detection (LC-MS/MS) (Gergov et al, 2001;Gupta et al, 2005;de Jager et al, 2002;Rudaz et al, 2003;Song et al, 2005;Tan et al, 2006). Previously published methods included also gas chromatography (GC) (Baltes et al, 1988), high-performance thin-layer chromatography (HPTLC) (Makhija and Vavia, 2001;Pandya et al, 1996), electrooxidation (Güngör, 2004), spectrophotometric (El Walily et al, 1998;Mahgoub et al, 2003;Gowda et al, 2001;Basavaiah and Charan, 2002;Basavaiah et al, 1999;Gazy et al, 2002), titrimetric technique (Basavaiah and Charan, 2002) for cetirizine determination and assay based on cetirizine-tetraphenylborate ion-pair analysis (Shoukry et al, 1999). However, most of these procedures are time-consuming, not specific or selective enough.…”

Section: Introductionmentioning

confidence: 99%

“…However, most of these procedures are time-consuming, not specific or selective enough. A literature survey reveals that the majority of the papers describe the measurement in pharmaceutical formulations (Jelinska et al, 2000(Jelinska et al, , 2001Paw et al, 2002;Arayne et al, 2005;Bajerski et al, 2005;El Walily et al, 1998;Jaber et al, 2004;Nagaralli et al, 2003;Likar et al, 2005;Rudaz et al, 2003;Makhija et al, 2001;Güngör, 2004;Mahgoub et al, 2003;Gowda et al, 2001;Basavaiah and Charan, 2002;Basavaiah et al, 1999;Gazy et al, 2002;Shoukry et al, 1999). There are only a few reports on the cetirizine analysis in human (Macek et al, 1999;Kim et al, 2005;Nagaralli et al, 2003;de Jager et al, 2002;Song et al, 2005;Tan et al, 2006;Baltes et al, 1988;Pandya et al, 1996) or animal plasma samples (Choi et al, 2000a;Gupta et al, 2005), which have been based on HPLC following some form of liquid-liquid extraction (LLE) (Macek et al, 1999;Choi et al, 2000a;Kim et al, 2005;Nagaralli et al, 2003;Gupta et al, 2005;de Jager et al, 2002;Tan et al, 2006) or solidphase extraction (SPE) (Song et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

Kowalski

Plenis

2007

Biomedical Chromatography

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Two methods, capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC), for analysis of cetirizine dihydrochloride in small sample volumes of human plasma were compared. The CE and HPLC assays were developed and validated by analyzing a series of plasma samples containing cetirizine dihydrochloride in different concentrations using these two methods. The extraction procedure is simple and no complicated purification steps or derivatization are required. The analysis time in the HPLC method was shorter than that in the CE method, but solvent consumption was considerably lower in the CE method. The calibration curve was linear to at least 10-1000 ng/mL both for CE and HPLC with r(2) = 0.9993 and r(2) = 0.9994, respectively. The detection limits for cetirizine dihydrochloride were 3 and 5 ng/mL with CE and HPLC (a UV detector was applied in the both cases), respectively. Both methods were selective, robust and specific, allowing reliable quantification of cetirizine dihydrochloride, and could be useful for clinical and biomedical investigations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

Kowalski

Plenis

2007

Biomedical Chromatography

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“…Extractive spectrophotometric procedures have received considerable attention for quantitative determination of many organic compounds of pharmaceutical interest [26][27][28][29][30] employing many dyes including alizarin red S (AZS) [31][32][33]. This study was directed to develop two accurate, selective, precise, and inexpensive procedures for the determination of FFH in pharmaceuticals based on ion-pair complex formation using AZS as a reagent.…”

Section: Introductionmentioning

confidence: 99%

Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

et al. 2012

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The present study describes two simple, rapid, selective, and cost-effective spectrophotometric methods for the determination of an antiallergic drug, fexofenadine hydrochloride (FFH), in bulk drug, tablets, and in spiked human urine. The first method (method A) is based on the formation of yellow-colored ion-pair complex between FFH and alizarin red S (AZS) in acid medium which was extracted into dichloromethane, and the absorbance was measured at 440 nm. The second method (method B) is based on the breaking of the yellow FFH-AZS ion-pair complex in alkaline medium followed by the measurement of the violet-colored free dye at 590 nm. Under the optimized conditions, Beer's law is obeyed over the concentration ranges of 0.4-12.0 and 0.2-3.5 μg mL −1 FFH for method A and method B, respectively, and the corresponding molar absorptivity values are 3.80 × 10 4 and 1.61 × 10 5 L mol −1 cm −1 . The Sandell's sensitivity, detection, and quantification limits are also reported. The proposed methods were successfully applied to the determination of FFH in pure drug and commercial tablets. The accuracy and reliability of the proposed methods were further established by recovery studies via standard addition technique.

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“…Different analytical methods for determination of this antihistaminic in biological fluids (urine, plasma, serum) have been reported and include HPLC, [6][7][8][9] HPLC-MS, [10][11][12] CG, 13 HPTLC, 14 and TLC. 15 In pharmaceutical dosage forms (tablets, compounded capsules, solutions) this drug was analyzed isolated by HPLC, [16][17][18][19] HPLC-MS, 20 and spectrophotometry, 4,16,21,22 or combined with multicomponent dosage forms by spectrophotometry, 22 HPTLC, 23 and HPLC. 24 Traditionally, pharmaceutical analysis relies heavily on HPLC.…”

Section: Introductionmentioning

confidence: 99%

Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC

Bajerski¹,

Sangoi²,

Barth³

et al. 2010

Quím. Nova

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Recebido em 13/2/09; aceito em 21/7/09; publicado na web em 25/11/09 A capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L -1 sodium tetraborate buffer (pH 9.3) as background electrolyte, a hydrodinamic sample injection at 50 mBar for 5 s, 20 KV applied voltage at 25 °C, and detection at 232 nm. The proposed method was compared with the high performance liquid chromatographic (HPLC) method previously validated for this drug, and statistical analysis showed no significant difference between the techniques.

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Spectrophotometric determination of ceterizine hydrochloride with Alizarin Red S

Cited by 28 publications

References 10 publications

Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples

Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC

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