Spectrophotometric Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations by Oxidative Coupling reaction.

Anwar, Sunbul Mustafa

doi:10.32894/kujss.2018.13.3.3

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…An auto-sampler can also automate devices for sample injection and data processing. [20] To guarantee a high level of precision, two, parameters must be managed. First, and foremost, accurate timing is necessary, The system flow rate needs to be ,precisely managed because The species is not in balance, and the sample holding time determines how much dispersal there is Second, a highly reproducible ,sample bolus must be injected ,into the carrier stream by carefully, controlling the sample volume and, injection timing.…”

Section: Sample Introductionmentioning

confidence: 99%

Fabrication of Coupling Approach between Flow Injection System – Ion Selective Electrode

Alsultany,

Al-Juboory,

Abdallah

et al. 2023

Kirkuk J. Sci.

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In real-time monitoring applications where batch calibration approaches cannot be easily performed, the strategy of coupling between FIA and ISEs in FIA-ISEs is ideal for usage. On the other hand, manual manipulation of the solutions continues to be the foundation of current analytical equipment. The automated technique Flow Injection Analysis (FIA), combined with the urgent requirement for automated approaches, a significant influence of contemporary characterization methods are carried out. The flow injection analysis is a method involving clear operating fundamentals that shows promise. And although the electrodes are very selective, they are not free, therefore they link with ion selective (IS) as a detector on Selective Electrodes (ISEs) that are used to monitor some of the most important analyses on clinical laboratory and point of care analyzers.

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Section: Sample Introductionmentioning

confidence: 99%

Fabrication of Coupling Approach between Flow Injection System – Ion Selective Electrode

Alsultany,

Al-Juboory,

Abdallah

et al. 2023

Kirkuk J. Sci.

View full text Add to dashboard Cite

show abstract

“…6 Thereafter, the method wasreportedly furthersimplified and modified to be anadopted procedure under conventional laboratory conditions for rapid determination of CPZ in injectable veterinary formulations. 4,5 Other more elaborate analytical spectrophotometric [6][7][8][9][10][11] and high performance liquid chromatography [12][13][14] techniques are available for the determination of CPZas well as other phenothiazine derivatives in pharmaceutical formulations.However, no direct comparison was attempted between the designated spectrophotometric method of CPZ determination 4,5 and a standardized HPLC procedure.…”

Section: Introductionmentioning

confidence: 99%

Comparative Determination of Chlorpromazine in Pharmaceutical Injectable Veterinary and Human Formulations by Spectrophotometric and High Performance Liquid Chromatographic Methods

Fouad K. Mohammad,

Lubna A. Kafi,

Nabaa K. Al-Hayani

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Chlorpromazine (CPZ) is a phenothiazine tranquilizer used in humans and animals. Rapid determination of the drug in pharmaceutical preparations is often needed. The aim of the study was to further examine and ascertain asimple spectrophotometric method in comparison with a high performance liquid chromatographic (HPLC) method for the determination of CPZ concentrations in injectable pharmaceutical formulations used in man and animals. Methods: Concentrations of CPZ in injectable pharmaceutical formulations for human and veterinary uses were determined by a modified spectrophotometric method and by an HPLC method with appropriate standard calibration curves. The spectrophotometric method of CPZ determinationwas conducted by diluting 0.1 ml of the veterinary (5%) or 0.3 ml of human (0.5%) formulations to 200 ml of 0.1N sulfuric acid. Four ml of the diluted CPZ samples or the standard solutions were mixed with 2 ml of 50% sulfuric acid. Then an aliquot of 0.2 ml of 2% ferric nitrate was added to the mixture. After 15 minutes, the absorbance was measured at 530 nm against water and vehicle blanks using a spectrophotometer. The HPLC method applied in the present study consisted of reversed phase gradient chromatography with a C 18 column and the eluent was (A) 50 mmol NaH 2 PO 4 , pH 2.5 and (B) acetonitrile -50 mmol NaH 2 PO 4 , pH 2.5 (60:40 v/v), flow rate at 1 ml/min, with a gradient of 15-55% B in 10 min, to 100% B in 20 min, and 280-nm UV detection. From the calibration curves of CPZ standards, the following were calculated: Limit of detection limit (LOD) = 3.3 x SD/slope; Limit of quantitation (LOQ) = 10 x SD/slope, where SD is the standard deviation of response of CPZ concentrations of the calibration curves.Linear regression analysis and related coefficients of correlations were applied on the calibration curves. Results: The calibration curves of CPZ against water or vehicle blanks as determined by the spectrophotometric method or by the HPLC method were linear with strong correlations (r = and / or >0.99). Based on the calibration curves, limit of detection and limit of quantitation the spectrophotometric method were comparable to those of the HPLC one. The contents CPZ in human and veterinary injectable formulations as determined by the spectrophotometricmethod were in accordance (100.6% and 102%, respectively)to the concentrations claimed on the labels of the formulations. Conclusion:The present results introduce a simple spectrophotometric method that could be used for routine measurement of CPZ concentrations in pharmaceutical formulations, with the added benefits of linearity, precision and cost effectiveness.

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Spectrophotometric Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations by Oxidative Coupling reaction.

Cited by 2 publications

References 5 publications

Fabrication of Coupling Approach between Flow Injection System – Ion Selective Electrode

Fabrication of Coupling Approach between Flow Injection System – Ion Selective Electrode

Comparative Determination of Chlorpromazine in Pharmaceutical Injectable Veterinary and Human Formulations by Spectrophotometric and High Performance Liquid Chromatographic Methods

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