Spectrophotometric determination of fluoxetine and sertraline using chloranil, 2, 3 dichloro-5, 6 dicyano benzoquinone and iodine

Bebawy, Lories I.; El-Kousy, Naglaa; Suddik, Jihan K.; Shokry, Mohamed

doi:10.1016/s0731-7085(99)00101-6

Cited by 59 publications

(32 citation statements)

References 27 publications

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“…The main disadvantages of HPLC are the relatively long analysis times and the high acquisition and maintenance costs. Several other methods based on micellar electrokinetic capillary chromatography [9], isotachophoresis [10], gas chromatography-mass spectrometry/nitrogen phosphorus detector [11][12][13][14][15] and UV-vis spectrophotometry [16] have also been described. No assay methods for STR determination are reported in the British, United States and European Union Pharmacopoeias.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical study of the antidepressant sertraline

Nouws

Delerue–Matos

Barros

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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A flow injection square wave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20 × 10 −6 and 1.20 × 10 −6 mol L −1 . Limits of detection and quantification were found to be 1.5 × 10 −7 and 5.0 × 10 −7 mol L −1 , respectively. Up to 70 samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs, opening the possibility to compete with the chromatographic methods generally used for this analysis.

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Section: Introductionmentioning

confidence: 99%

Electroanalytical study of the antidepressant sertraline

Nouws

Delerue–Matos

Barros

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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“…These acceptors react with the basic nitrogenous compounds to form charge transfer complexes or radical anions according to the polarity of the solvent used (Bebawy, 1999). Hence p-chloranil was used in this stage of work as the reagent for the determination of CPT in the presence of hydrogen peroxide.…”

Section: Captopril/p-chloranil/h 2 O 2 Systemmentioning

confidence: 99%

Development and application of a portable instrument for drugs analysis in pharmaceutical preparations

Ribeiro

Pezza

et al. 2015

Braz. J. Pharm. Sci.

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This article describes the application and performance of an inexpensive, simple and portable device for colorimetric quantitative determination of drugs in pharmaceutical preparations. The sensor is a light detector resistor (LDR) incorporated into a black PTFE cell and coupled to a low-cost multimeter (Ohmmeter). Quantitative studies were performed with captopril/p-chloranil/H 2 O 2 and methyldopa/ ammonium molybdate systems. Calibration curves were obtained by plotting the electrical resistance of the LDR against the concentration of the colored species in the ranges 1.84 × 10 -4 to 1.29 × 10 -3 mol L -1 and 5.04 × 10 -4 to 2.52 × 10 -3 mol L -1 for captopril/p-chloranil/H 2 O 2 and methyldopa/ammonium molybdate systems, respectively, exhibiting good coefficients of determination. Statistical analysis of the results obtained showed no significant difference between the proposed methodologies and the official reported methods, as evidenced by the t-test and variance ratio at a 95% confidence level. The results of this study demonstrate the applicability of the instrument for simple, accurate, precise, fast, in situ and low-cost colorimetric analysis of drugs in pharmaceutical products. Uniterms:Optical sensor/application/colorimetric analysis. Instrumentation/drugs dosage. Drugs/ quantitative analysis. Drugs/dosage. Pharmaceutical formulations/quality control.Este artigo descreve o desenvolvimento e a aplicação de um dispositivo portátil, simples e barato para a determinação colorimétrica quantitativa de fármacos em formulações farmacêuticas. O sensor é um resistor detector de luz (RDL) colocado numa célula de PTFE e acoplado a um multímetro de baixo custo. Os estudos quantitativos foram realizados utilizando captopril/p-cloranil/H 2 O 2 e metildopa/molibdato de amônio como sistemas reacionais. As curvas de calibração foram obtidas através da representação gráfica da resistência elétrica do RDL contra a concentração dos complexos coloridos formados nas faixas de 1,84 × 10 -4 e 1,29 × 10 -3 mol L -1 e 5,04 × 10 -4 e 2,52 × 10 -3 mol L -1 para captopril/p-cloranil/H 2 O 2 e de metildopa/molibdato de amônio, respectivamente, com bons coeficientes de determinação. As análises estatísticas dos resultados obtidos mostraram que não houve diferença significativa entre os métodos propostos e os métodos oficiais como evidente a partir dos testes "t-Student" e F-Fisher, com nível de confiança de 95%. Os resultados deste estudo demonstram que o instrumento proposto neste trabalho é simples, de fácil operação, baixo custo e apresentou boa exatidão e boa precisão para o doseamento de fármacos em medicamentos.Unitermos: Sensor óptico/aplicação/análise colorimétrica. Instrumentação/doseamento de fármacos. Fármacos/análise quantitativa. Fármacos/doseamento. Formulações farmacêuticas/controle de qualidade.

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“…All drugs gave red colored chromogens showing absorption maxima at 460, 545, and 593 nm. These bands were attributed to the formation of the radical anion DDQ - (14), which was probably formed by the dissociation of an original donor-acceptor (D-A) complex:…”

Section: Reaction and Spectral Characteristicsmentioning

confidence: 99%

A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs

Darwish¹,

Mahmoud²,

Al-Majed³

2010

Acta Pharmaceutica

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The present study describes the development of a novel analytical approach that can reduce by 50-fold the consumption of organic solvents in the charge transfer (CT)--based spectrophotometric analysis. The proposed approach employed 96-microwell assay plates for carrying out the reaction. The CT reaction between the electron--donating analyte and electron-accepting reagent was performed in microwells (200-mL of organic solvent) and the color signals were measured with a microwell-plate reader. Optimum conditions for the proposed approach were established for two antihypertensive drugs, namely ramipril (RML) and lisinopril (LSL) as model compounds for the electron-donating analytes, and 2,3-dichloro-5,6--dicyano-1,4-benzoquinone (DDQ) as a p-electron acceptor. Under the optimum conditions, Beer's law was obeyed in the concentration range of 6-100 and 6-60 mg mL -1 for RML and LSL, respectively. The limits of detection were 0.97 and 1.10 mg mL -1 for RML and LSL, respectively. The precision of the methods was satisfactory; the values of relative standard deviations did not exceed 1.1 %. The proposed approach was successfully applied to the analysis of pharmaceutical dosage forms with good accuracy and precision. The results were comparable with those of the reported methods. The approach described herein is of great practical value in pharmaceutical analysis because it reduces the exposure of analysts to the toxic effects of organic solvents, lowers the analysis cost by 50-fold, and it has a high throughput property. Although the approach was validated for RML and LSL, the same methodology could be used for any electron-donating analyte for which a CT-reaction can be performed.

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Spectrophotometric determination of fluoxetine and sertraline using chloranil, 2, 3 dichloro-5, 6 dicyano benzoquinone and iodine

Cited by 59 publications

References 27 publications

Electroanalytical study of the antidepressant sertraline

Electroanalytical study of the antidepressant sertraline

Development and application of a portable instrument for drugs analysis in pharmaceutical preparations

A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs

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