Spectrophotometric Determination of Mefenamic acid using Metol reagent by Oxidative Coupling Reaction

Rashad, Istabraq Qahtan; Bakir, Mohsin Hamza

doi:10.1088/1757-899x/1058/1/012081

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a concentration range of 2.4-24 µg/ml MFA with a molar absorptivity of 7.2x103 L/mol cm, Beer's law holds true which proves the suggested approach to be efficient. This procedure has been used to determine MFA in a variety of pharmaceutical formulations with great success [13].…”

Section: Spectroscopy Techniques Of Mfamentioning

confidence: 99%

Review for Analytical Methods for the Determination of Mefenamic Acid

Ashira¹,

Rafeeque²,

Maanvizhi

et al. 2021

JPRI

View full text Add to dashboard Cite

Mefenamic acid (MFA) is a non-steroidal anti-inflammatory drug that belongs to the anthranilic acid derivative family. It is used to relieve mild to moderate pain. The present review article includes a compilation of articles on the various properties along with an extensive literature survey on the reported analytical methods of MFA. Using a comprehensive computer assisted literature review; this article discusses the analytical methodologies for quantifying MFA both in active pharmaceutical ingredient and pharmaceutical dosage forms. This is the first review article in this series with focus on the analytical profile of MFA. Although, several methods like High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), spectrophotometry, fluorimetry, turbidimetry, Atomic Absorption Spectroscopy (AAS), Mass Spectroscopy (MS) and electro analytical methods were reported in the literature, HPLC stands out first for the quantification of MFA.

show abstract

Section: Spectroscopy Techniques Of Mfamentioning

confidence: 99%

Review for Analytical Methods for the Determination of Mefenamic Acid

Ashira¹,

Rafeeque²,

Maanvizhi

et al. 2021

JPRI

View full text Add to dashboard Cite

show abstract

“…2) (Gouda and Amin 2010). A literature survey reveals that various analytical techniques were used for the determination of MFA such as UV spectrophotometry (Rashad and Bakir 2021), Thin layer chromatography (TLC) technique (Lillesand and Korte 2021), Highperformance liquid chromatography (HPLC) technique (Jafari and haji 2020), Hydrotropic solubilization technique (Sharma and Sahoo 2021) Digital imaging colorimetry (Nepomuceno and Lemos et al, 2022) Merging zonecontinuous flow injection (Al-Ameer, Hashim and Taha 2022) , Electrochemical sensors (Valian and Niasari,2022), Gas chromatography (Jalbani and Solangi et al, 2020) , Flow injection fluorometry (Hamed and Hammood 2020) Therefore, a quick, inexpensive, and selective approach is clearly required, particularly for regular quality improvement screening of pharmacological products which have MFA. However, an application of that suggested technique to the detection of MFA in a bulk tablet, and other products was that proved successful (Saleem and Alnuaimy 2021).…”

Section: Introductionmentioning

confidence: 99%

A Novel Spectrophotometric Approach for Estimation of Non-steroidal anti-inflammatory drugs (NSAIDs) in Pharmaceutical Drug formulations by Neocuproine

Nayef,

Hussain,

Taha

2023

Egyptian Academic Journal of Biological Sciences. C, Physiology

View full text Add to dashboard Cite

A novel, simple, accurate, sensitive, reproducible, economical method for spectrophotometric approach for measuring MFA in Pharmaceutical Drug formulations was successfully developed and verified. A novel analytical technique for estimating MFA 250 mg in capsule pharmaceutical formulations for different brands was established. The method suggested is based on the reduction of Cu(II)-2,9DMP complex to colored Cu(I)-2,9DMP complex. The optimum experimental conditions have been achieved. Beer'ss Law holds true in the concentration levels 5.0-60 μg/mL with accurate molar absorptivity of 0.238 L/mol.cm at 454 nm and "detection limit" was 0.5882 μg/mL and the limit of quantification was 1.7825 μg/mL and correlation coefficient obtained has been near to one. The Effect of pH, reaction time, Buffer Solutions, Volume of Cu(ІІ), Volume of 2,9.DMP reagent, temperature, Order of Addition, and Effect of Acid on the determination of MFA, have been examined. The proposed method has been successfully utilized for quantitative assessment of commercially produced dosage modes. Our research sought to develop a fresh, accurate, and sensitive technique for measuring MFA as a pure pharmacological product and as a hard dosage. The creation of a metal complex of MFA with a copper ion is a prerequisite for the spectrophotometric approach.

show abstract

“…Through repeatable and accurate timing, the FI approach can measure the properties of metastable and transitory species. Multiple measurements developed for clinical, pharmacological, dietary, and environmental studies have demonstrated the value of FI methods for regular analysis [10,[16][17][18][19][20][21][22][23][24][25][26]. When the reagents used are expensive, and the model is cheap and available in large quantities, it is preferable to reverse the injection process.…”

Section: Introductionmentioning

confidence: 99%

Determination of Mefenamic Acid in Aqueous Solutions Using Reverse - Continuous Flow Injection Analysis

2022

pnr

View full text Add to dashboard Cite

This research aims to use a novel algorithm to determine the concentration of Mefenamic acid. The MA concentration in aqueous solutions was determined using this technology, and the results obtained using more conventional methods were compared to those obtained using more traditional methods. A signal detector and a specialized software spectrometer then receive the data. The maximum wavelength of the product is determined using a spectroscopic scan, a calibration curve is constructed, and measurements are made to estimate the drug's absolute concentrations in aqueous solutions. This treatment is popular because it is simple, rapid, precise, inexpensive, and adaptable.

show abstract

Spectrophotometric Determination of Mefenamic acid using Metol reagent by Oxidative Coupling Reaction

Cited by 5 publications

References 0 publications

Review for Analytical Methods for the Determination of Mefenamic Acid

Review for Analytical Methods for the Determination of Mefenamic Acid

A Novel Spectrophotometric Approach for Estimation of Non-steroidal anti-inflammatory drugs (NSAIDs) in Pharmaceutical Drug formulations by Neocuproine

Determination of Mefenamic Acid in Aqueous Solutions Using Reverse - Continuous Flow Injection Analysis

Contact Info

Product

Resources

About