Spectrophotometric determination of mesalazine in urine for assessing the acetylation phenotype in vivo in humans

Garmonov, S. Yu.; Dung, Nguyen Trung; Mingazetdinov, I. F.; Yusupova, L. M.; Shitova, N. S.; Исмаилова, Р. Н.; Sopin, V. F.

doi:10.1007/s11094-012-0719-y

Cited by 18 publications

(7 citation statements)

References 10 publications

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“…Up to now a number of analytical methods have been used for the analysis of MSA in many biological matrices and pharmaceuticals, such as HPLC combined with UV 8–11, fluorescence (FL) 9, 10, 12, 13 and electrochemical (EC) 10, 14 and detections, micellar electrokinetic capillary chromatography (MECC) 15, micellar electrokinetic chromatographic (MEKC) 16, spectrophotometry 17, fluorescence spectroscopy 18, automated chemiluminescence 19, liquid chromatography (LC) 20, ion‐pairing high‐performance liquid chromatography 21, liquid chromatographytandem mass spectrometry (LCMS/MS) 22 and high performance liquid chromatography electrospray ionization‐mass spectrometry (HPLCESI‐MS/MS) 23. However, spectrophotometric and chromatographic methods usually are time consuming and laborious and require sample preparation process (e.g.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Electrochemical Behavior of Mesalazine on the Surface of a Glassy Carbon Electrode Modified with CNT/PPY Doped by 1,5‐Naphthalenedisulfonic Acid

2013

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A glassy carbon electrode (GCE) was modified with a thin layer of multiwalled carbon nanotubes (MWCNTs) and subsequently, electrochemically deposited poly‐pyrrole. The electrochemical behavior of mesalazine was studied on the surface of the modified electrode by applying linear sweep voltammetry (LSV). The electropolymerization process and the electrochemical response toward mesalazine were investigated in the presence of different aromatic anion dopants including, benzenesulfonic acid (BSA), 1,3‐benzenedisulfonic acid (1,3‐BDSA), 1,5‐naphthalenedisulfonic acid (1,5‐NDSA) and new coccine (NC). By using 1,5‐NDSA as dopant, a significant increase (∼418 times) in the peak current of mesalazine was observed, in comparison to the bare GCE. Experimental variables such as drop size of the cast MWCNTs suspension, pH of the supporting electrolyte, accumulation conditions and the number of scans in the electropolymerization process were optimized by monitoring the LSV responses of mesalazine. Under the optimum conditions, two linear dynamic ranges of 0.01–0.1 µmol L−1 and 0.1–1.0 µmol L−1 with a detection limit of 3 nmol L−1 were resulted for the voltammetric determination of mesalazine. The prepared electrode showed high sensitivity, stability and good reproducibility for determination of mesalazine. These properties made the prepared sensor suitable for the determination of mesalazine in pharmaceutical and clinical preparations.

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Section: Introductionmentioning

confidence: 99%

Investigation of the Electrochemical Behavior of Mesalazine on the Surface of a Glassy Carbon Electrode Modified with CNT/PPY Doped by 1,5‐Naphthalenedisulfonic Acid

2013

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“…Invented narrative survey found out that, there are a not many analytical techniques used for the strength of mind of MSZ in pharmaceutical preparations and organic samples the use of spectrophotometer. 7,8 Chemiluminesence, Fluorescence, Ultraperformance liquid chromatography were moreover been accounted. [9][10][11][12][13][14] Among the entire above declared strategies, the improvement of most recent analytical manners used for the resolve of Mesalazine drug be of luminous materials are contained by the recent period.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Recognition and Electrochemical Oxidation of Mesalazine Drug at PMA Modified Glassy Carbon Electrode

Gupta¹,

Vallabhaneni²

2021

IJPI

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Background: Electrochemistry was the foremost subdivision of the chemistry its interred correlated to the entire other chemistries. Primarily it can settle on the nature of compound reactions by physically depends on the applying extent of electricity. The magnitude container is agreed away in connecting the optimistic and negative electrodes at the being there of analytic nearby in solution medium. Thus the electrochemistry is essentially depended on the reaction of chemical changes are by the persuade current of applying, on this perception the electricity is on the inside associated to the chemical type which are in attendance in the chemical compounds. These genus are sensitive to the functionalised electric value of potentials, and it was seen in varying of chemical reactions. In that basis, the changing of reactions is extensive in electrochemical reactions. Methods: In this Cyclic Voltammetry experimental method, crucial principal subsequent, instrumentation, and chemical changing noticing potentiostat of the electrochemical cell and recording apparatus are studied. The working electrodes are glassy carbon electrode was used for the harvest of this research work. How the glassy carbon electrode is useful to bring good results from using analytes. The procedures for doing a modification with modifiers on the surface of the electrode are clearly discussed. Results: A quick-tempered and miniature responsive analytical advance became evolved for the electrochemical oxidation of Mesalazine (MSZ) the procedure of electro ionic deposited modified PMA altered glassy carbon electrode (MGCE). The distorted electrode specify electrocatalytic attention in the bearing of the oxidation of MSZ drug in 0.2M phosphate buffer solution (PBS) of pH 7.4 with the assist of using cyclic voltammetric (CV) technique. The restrict of detection develop into calculated to be 79.50nM at misused electrode. The impacts of experiment charge observe shows evidence of an adsorption deal with electrode phenomenon. The altered electrode might be used as an analytical apparatus for the enthusiasm MSZ drug in pharmaceutical formulations. Conclusion: The planned electrode deposited PMA MGCE grows to be engaged for the electro-oxidation and stamina of an imperative drug MSZ at physiological pH by revenue of the use of CV modus operandi. The discovery perimeter grows to be calculated to be 79.50nM on behalf of MSZ with the method of CV.

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“…Various analytical methods were described in the literature for the determination of 5-ASA, such as liquid chromatography coupled to mass spectrometry for drug quantification in plasma samples [3], HPLC with UV detection for stability-indicating assays [4] and analysis in pharmaceutical formulations [5], capillary electrophoresis for drug impurity profiling [6], spectrophotometry [7], fluorescence spectroscopy [8], automated chemiluminescence [9] and ultra-performance liquid chromatography [10]. At present, several HPLC methods with a fluorescence [11][12][13], electrochemical [14,15] and mass spectrometry detection [16,17] were developed for simultaneous quantification of 5-ASA and its N-acetylated metabolite.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical sensing of mesalazine and its N-acetylated metabolite in biological samples using functionalized carbon nanotubes

Nigović

Sadiković

Jurić

2016

Talanta

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Spectrophotometric determination of mesalazine in urine for assessing the acetylation phenotype in vivo in humans

Cited by 18 publications

References 10 publications

Investigation of the Electrochemical Behavior of Mesalazine on the Surface of a Glassy Carbon Electrode Modified with CNT/PPY Doped by 1,5‐Naphthalenedisulfonic Acid

Investigation of the Electrochemical Behavior of Mesalazine on the Surface of a Glassy Carbon Electrode Modified with CNT/PPY Doped by 1,5‐Naphthalenedisulfonic Acid

Electrochemical Recognition and Electrochemical Oxidation of Mesalazine Drug at PMA Modified Glassy Carbon Electrode

Electrochemical sensing of mesalazine and its N-acetylated metabolite in biological samples using functionalized carbon nanotubes

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