Spectrophotometric Determination of Metoclopramide and Oxybuprocaine Through Ion Pair Formation with Thiocyanate and Molybdenum(V) or Cobalt(II)

Abdel-Gawad, F. M.; El-Guindi, Nabawia M.

doi:10.1080/00032719508006405

Cited by 45 publications

(17 citation statements)

References 16 publications

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“…31) The reduction probability of Mo(VI) may occur by ascorbic acid or SCN Ϫ in acidic media 31) and react with thiocyanate to form a red binary Mo(V)-SCN Ϫ complex, non extractable with chloroform.…”

Section: Resultsmentioning

confidence: 99%

“…20) For fosinopril with H 2 -receptor antagonists by derivative spectroscopy, 21) UV and third derivative spectrophotometry, 22) microemulsion liquid chromatography, 23) HPLC in the presence of its degradation product fosinoprilate, 24) TLC procedures 25) and reversed-phase ion-pair liquid chromatography. 26) Several colorimetric methods for determination of some drugs in pharmaceutical preparations using molybdenum (V) (Mo(V)) thiocyanate reagent forming ion-pair complex were reported such as; chloroquine and pyrimethamine, 27) ampicillin, dicloxacillin, flucloxacillin and amoxacillin, 28) some piperazine derivatives, 29) trazodone, amineptine and amitriptyline hydrochloride, 30) metoclopramide and oxybuprocaine, 31) and some H 1 -antihistaminics. 32) Although the chromatographic methods are sensitive enough, they are expensive and not easily manageable.…”

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confidence: 99%

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Spectrophotometric and Atomic Absorption Determination of Ramipril, Enalapril Maleate and Fosinopril through Ternary Complex Formation with Molybdenum (V)-Thiocyanate (Mo(V)-SCN)

Baraka

El-Sadek

Moussa

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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Three different sensitive and accurate spectroscopic procedures were developed for the determination of three angiotensin-converting enzyme inhibitors, namely, ramipril, enalapril maleate and fosinopril. The first two spectrophotometric (extractive and non-extractive) procedures were based on ternary complex formation with molybdenum(V) thiocyanate. The formed complex can be determined by extraction with chloroform measured at l l max 517 nm Beer's law was obeyed in the concentration range from (10-90 m mg ml , respectively. The third procedure is atomic absorption measurement through the quantitative determination of molybdenum content of the complex. These methods hold their accuracy and precision well when applied to the determination of ramipril, enalapril maleate and fosinopril in their dosage forms.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Spectrophotometric and Atomic Absorption Determination of Ramipril, Enalapril Maleate and Fosinopril through Ternary Complex Formation with Molybdenum (V)-Thiocyanate (Mo(V)-SCN)

Baraka

El-Sadek

Moussa

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The method does not involve any critical reaction conditions and can be compared favourably with other existing methods [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] . The proposed method can serve as an alternative method for the routine analysis of MCP and DAP in pure drugs and in pharmaceutical formulations.…”

Section: Discussionmentioning

confidence: 99%

“…Several spectrophotometric methods have been reported for the determination of MCP and DAP based on diazotization and coupling with resorcinol or naphtha-2-ol 1 , dibenzoyl methane 2 , chromotropic acid 3 , 3-aminophenol and salbutamol 4 , NEDA 5 , ionassociation complex formation 6,7 , an oxidative coupling reaction 8 , charge-transfer complex formation 9 or through formation of the Schiff 's base with pdimethylaminocinnamaldehyde 10 . Other chromogenic reactions use sodium vanadate 11 , ammonium meta vanadate 12 , 3-methylbenzothiazolin-2-one hydrazone (MBTH) 3 , nitrous acid-cresyl fast-violet acetate (CFVA) 13 , 9-chloroacridine 14 , catechol 15 , sodium 3,4-dioxonaphthalene-1-sulphate 16 and Folin-ciocalteu reagent 17 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

Revanasiddappa¹,

Veena²

2006

ScienceAsia

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A simple, sensitive and selective spectrophotometric method for the determination of metoclopramide hydrochloride (MCP) and dapsone (DAP) in both pure and dosage forms is described. The method is based on the diazo -coupling reaction of the studied drugs with a new coupling agent, imipramine hydrochloride, in an acid medium. The resulting violet -colored azo dyes exhibit maximum absorption at 570 nm for both MCP and DAP. All variables were studied in order to optimize the reaction conditions. The method is suitable for the determination of MCP and DAP in the presence of other ingredients that are usually present in dosage forms and the recoveries were obtained in the range of 99.5-100.5%. The results are reproducible with an accuracy of ±1%, and the validity of the method was tested against reference method.

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“…12,13) Thus these methods suffer from strongly interferences of drug excipients and diluents. Spectrophotometric determination of these drugs has been proposed based on diazotization, [14][15][16][17] ion pair complexes, 18) charge transfer complexes, 19,20) and the formation of coloured Schiffs base upon interaction with dimethylaminocinnamaldehyde 21) and use of 9-chloroacridine 22) and sodium 1,2-naphthoquinone-4-sulfonic 23) as chromogenic reagents. These methods involve a time-consuming extraction procedures or heating and require strictly controlled reaction conditions.…”

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confidence: 99%

Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

Omran

2005

Chem. Pharm. Bull.

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Dapsone (DAP), 4,4Ј-diaminodiphenyl sulfone, is used to treat leprosy and other skin conditions. 2) It may also be used to prevent malaria, for certain types of arthritis or other inflammatory conditions and pneumocystis carinii pneumonia (PCP). Metoclopramide hydrochloride (MCP), chemically, 4-amino-5-chloro-[2-(diethylamino)ethyl]-2-methoxybenzamide HCl is used to relieve certain stomach and esophagus problems such as diabetic gastroparesis and gastroesophageal reflux disorder (GERD). 3) Oral MCP may also be used to prevent nausea and vomiting caused by other medications. Moreover, MCP may be used in the fields of surgery, gynecology, cardiology and radiology.Due to their wide administration, considerable work has been done for determination of DAP and MCP include HPLC, 4-7) electron capture gas chromatography [8][9][10] and GC-MS 11) but involve an expensive experimental setup. Official methods for the determination of these drugs are usually based on extraction of the drug as a free base and its subsequent determination by UV-spectrophotometry. 12,13) Thus these methods suffer from strongly interferences of drug excipients and diluents. Spectrophotometric determination of these drugs has been proposed based on diazotization, [14][15][16][17] ion pair complexes, 18) charge transfer complexes, 19,20) and the formation of coloured Schiffs base upon interaction with dimethylaminocinnamaldehyde 21) and use of 9-chloroacridine 22) and sodium 1,2-naphthoquinone-4-sulfonic 23) as chromogenic reagents. These methods involve a time-consuming extraction procedures or heating and require strictly controlled reaction conditions. Many of these methods are less sensitive.For routine quality control, development of a simple, rapid and sensitive spectrophotometric method is highly desirable. In this paper, the employment of benzoylacetone as a new coupling agent for simple, rapid, accurate, precise and an inexpensive method for determination of DAP and MCP in bulk and pharmaceutical preparations is described. Furthermore, a simple first derivative spectrophotometric procedure has been applied to the simultaneous determination of DAP and MCP in synthetic binary mixture and pharmaceutical preparations without prior separation. ExperimentalApparatus A double-beam UV/Vis spectrophotometer (Perkin Elmer, lambda 3B) interfaced to IBM compatible computer with the capability of derivative mode operation was used. The spectra were recorded in 1-cm matched quartz cells. Suitable settings for recording the first-derivative spectra were: scan speed, 120 nm/min; response time, 2 s; spectral slit width, 2 nm; Dl, 1 nm; the ordinate minimum and maximum were Ϯ0.2 for the determination of DAP and MCP. The derivative spectra were obtained by numerical calculation with the aid of PECSS program using Savitzky-Golay algorithm. 24) Measurement of pH was carried out with a Janco electronics LTD digital pH-meter with a combined glass Calomel electrode.Reagents and Chemicals All chemicals were of analytical-reagent grade. Benzoylacetone (BAC, 2ϫ10 Ϫ...

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Spectrophotometric Determination of Metoclopramide and Oxybuprocaine Through Ion Pair Formation with Thiocyanate and Molybdenum(V) or Cobalt(II)

Cited by 45 publications

References 16 publications

Spectrophotometric and Atomic Absorption Determination of Ramipril, Enalapril Maleate and Fosinopril through Ternary Complex Formation with Molybdenum (V)-Thiocyanate (Mo(V)-SCN)

Spectrophotometric and Atomic Absorption Determination of Ramipril, Enalapril Maleate and Fosinopril through Ternary Complex Formation with Molybdenum (V)-Thiocyanate (Mo(V)-SCN)

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Individual and Simultaneous Spectrophotometric Determination of Dapsone and Metoclopramide HCl in Pharmaceutical Dosage Forms and Synthetic Binary Mixtures

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