Spectrophotometric determination of microgram amounts of penicillins by solvent extraction with azure b

Abstract

Summaw. Penicillins are determined by means of ion-pair formation with azure B and extraction into chloroform:the absorbance of the extract is stable for several days. The apparent molar absorptivities for sodium penicillin G and potassium penicillin V at 634 nm are 3.91 x 10' and 1.25 x 10' 1 mol-' cm-', respectively_ Calibration graphs are linear over the range 60-950 pg of sodium penicillin G and 40-600 pg of potassium penicillk V in 10 ml. The method is successfully applied to pharmaceutical preparations.

Determination of some antipsychotropic and anticholinergic phenothiazine drugs by vanadium (V) titration

“…Most of the proposed methods are unsatisfactory for one reason or the other. The chloramine -T titrimetric procedure [6] is not suitable for micro determination. In non-aqueous titrimetry [3], the medium has to be scrupolously anhydrous.…”

“…Several methods proposed for their determination have been reviewed by Karpinska et al [3] and Fairbrother [4]. The * To whom correspondence should be addressed commonly used titrimetric procedures are non-aqueous [5], oxidimetric [6,7], complexometric [8,9], back [10,11] and two-phase [12,13] titrations. The official methods are based on spectrophotometry and non-aqueous titration [14].…”

Use of an Oxidation Reaction for the Quantitative Determination of Albendazole with Chloramine-T and Acid Dyes

“…The versatility of Chloramine-T as an analytical reagent can be gauged by its applications in the titrimetric [27][28][29][30][31][32][33] and spectrophotometric [34][35][36][37][38][39][40] determination of many oragnic compounds of therapeutic importance. The use depends mainly on its ability to effect the oxidation of diverse functional groups.…”

Determination of penicillin V potassium in pharmaceuticals and spiked human urine by chemiluminescence

“…PVK determination is important in biotechnological production process control and antibiotic preparation quality control. A literature survey reveals several methods for PVK determination including spectrophotometry [2][3][4], HPLC [5][6][7], liquid chromatography [8], and capillary electrophoresis [9]. Chemiluminescent (CL) reactions have potential for a great variety of analytical applications thanks to their high sensitivity, wide linear range, simplicity, and inexpensive instrumentation [10][11][12].…”