Use of an Oxidation Reaction for the Quantitative Determination of Albendazole with Chloramine-T and Acid Dyes

Basavaiah, K.; Prameela, H. C.

doi:10.2116/analsci.19.779

Cited by 22 publications

(25 citation statements)

References 30 publications

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“…Many dyes are irreversibly destroyed to colourless products by oxidizing agents in acid medium 27 and this observation has been exploited for the indirect spectrophotometric determination of some bioactive compounds. [28][29][30][31][32] In recent years, acidified solution of bromate and bromide and dyes have been adapted to the quantification of several pharmaceutical substances. [19][20][21][22][23][24][25] In the proposed spectrophotometric methods, the ability of bromine to cause bromination of AST and irreversibly destroy methyl orange and indigo carmine dyes to colourless products in acid medium has been used.…”

Section: Methods Developmentmentioning

confidence: 99%

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Nagegowda¹,

Basavaiah²

2005

J. Braz. Chem. Soc.

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Um método titrimétrico e dois espectrofotométricos, simples e sensíveis, são descritos para a determinação de astemizola (AST) em drogas comerciais e formulações. Os métodos usam a mistura brometo-bromato e dois pigmentos, laranja de metila e índigo carmim. Na titrimetria (Método A), astemizola é tratada com uma mistura ácida de brometo-bromato em excesso conhecido e depois do término completo da reação de bromatação, o excesso de bromo é reversamente titulado iodometricamente. Nos métodos espectrofotométricos, o excesso de bromo é estimado após o tratamento com uma quantia determinada de laranja de metila (Método B) ou índigo carmim (Metodo C), e as mudanças de absorbância medidas em 520 e 610 nm, respectivamente. Em todos os métodos, a quantidade de bromato reagido corresponde à quantidade na droga. O método tritrimetrico é aplicável na faixa de 4-16 mg e os cálculos são feitos numa relação 1:0,666 (AST:bromato). Nos espectrofotométricos, a curva de calibração é linear entre 0,5 e 4,0 µg mL (Método B) e entre 1,25 e 12,5 µg mL (Método C), com valores de absortividade molar de 6,6x10, respectivamente. Os limites de detecção e quantificação são apresentados para os Métodos B e C. A avaliação estatística foi examinada pela precisão da determinação intra-e inter-diária. Os métodos são aplicáveis na determinação de AST em cápsulas e xaropes, e os resultados são concordantes com os apresentados em rótulo. A exatidão e confiabilidade dos métodos foram testadas pela determinação paralela por um método de referência, com limite de confiança de 95% para valores t-Student e F-Student, e por estudos de recuperação por adição padrão.One titrimetric and two spectrophotometric methods, which are simple and sensitive, are described for the determination of astemizole (AST) in bulk drug and formulations. The methods use bromatebromide mixture and two dyes, methyl orange and indigo carmine. In titrimetry (Method A), astemizole is treated with a known excess of bromate-bromide mixture in acid medium and after the bromination reaction is ensured to be complete, the residual bromine is back-titrated iodometrically. In spectrophotometric methods, the excess of bromine is estimated by treating it with a fixed amount of either methyl orange (Method B) or indigo carmine (Method C) and measuring the change in absorbance either at 520 or 610 nm. In all the methods, the amount of bromate reacted corresponds to the drug content. Titrimetric method is applicable over 4-16 mg range and the calculations are based on a 1:0.666 (AST: bromate) reacting ratio. In spectrophotometry, the calibration graph is found to be linear over 0.5-4.0 µg mL -1 (Method B) and 1.25 -12.5 µg mL -1 (Method C) with molar absorptivity values of 6.6 x 10 4 L mol -1 cm -1 and 2.1 x 10 4 L mol -1 cm -1, respectively. The limits of detection and quantification are reported for methods B and C. The statistical evaluation of the methods was examined by determining intra-day and inter-day precision. The methods were applied to the determination of AST in tablets and syrup...

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Section: Methods Developmentmentioning

confidence: 99%

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Nagegowda¹,

Basavaiah²

2005

J. Braz. Chem. Soc.

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“…The techniques have included titrimetry (Mohammed et al, 1986;Basavaiah and Prameela 2003;Basavaiah and Prameela 2003;Basavaiah and Nagegowda 2004;Basavaiah et al, 2004;Basavaiah and Prameela 2004;Basavaiah et al, 2006;Basavaiah et al, 2006), spectrophotometry (Kar 1985;Sastry et al, 1997;Basavaiah and Prameela 2003;Basavaiah and Prameela 2003;Basavaiah and Nagegowda 2004;Basavaiah et al 2004;Basavaiah and Prameela 2004;Basavaiah et al 2006;Basavaiah et al 2006;Kamel et al, 2008;Basavaiah et al, 2009;Tella et al, 2010;Refat et al, 2011;Swamy and Basavaiah 2014), spectrofluorimetry (Baeyens et al, 1985;Küçükkolbaşı et al, 2008;Zhao et al, 2008;Attia et al, 2016), liquid chromatography (Nakos et al, 1994;Fletouris et al, 1997;Balizs 1999;Garcia et al, 1999;Gomes and Nagaraju 2001;Kitzman et al, 2002;Danaher et al, 2007;Varghese et al, 2011) andvoltammetry (de Oliveira andStradiotto 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Most of the reported spectrophotometric method (Basavaiah and Prameela, 2003;Basavaiah and Prameela, 2003;Basavaiah and Nagegowda, 2004;Basavaiah et al 2004;Basavaiah and Prameela, 2004;Basavaiah et al 2006;Basavaiah et al 2006;Basavaiah et al 2009) were based on indirect determinations of the cited drugs through their oxidation and subsequent determination of the residual oxidant spectrophotometrically by reaction with another chromogenic reagent. Consequently these methods were time consuming, tedious and involved multi reagents and multi steps reactions.…”

Section: Introductionmentioning

confidence: 99%

Application of silver nanoparticles for the spectrophotometric determination of three benzimidazole anthelmintic drugs in their pharmaceutical preparations

Derayea¹,

Ali²,

Hamad³

et al. 2017

J App Pharma Sci

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This article describes the application of silver nanoparticles (AgNPs) as a colorimetric probe for the simple and selective determination of three anthelmintic benzimidazole drugs namely; albendazole, flubendazole and mebendazole. The method was based on the AgNPs aggregation induced by their interaction with the cited drugs. This interaction produced a color change from yellow to blue and accompanied by the appearance of a new surface plasmon resonance peak of AgNPs measured in the range of 615 -630 nm. The linear concentration ranges of the method were 2.0-9.0, 2.0-10 and 2.2-15 g mL -1 (r 2 = 0.9939, 0.9950 and 0.9938) for the studied drugs respectively. The validation of the analytical performance of the method was carefully investigated, and the results were satisfactory. This method was applied successfully to determine the three benzimidazoles in their pharmaceutical samples (tablets and suspensions) with high accuracy and precision. The suggested procedure is characterized by its simplicity since it does not involve solvent extraction or any critical reaction conditions.

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“…Titration is a quantitative analysis method used to determine the concentration of many active pharmaceutical ingredients such as tetraphenylborate sodium, phenothiazine compounds, acetaminophen, captopril, ascorbic acid, albendozole, sparfloxacin, salbutamol sulfate, montelukast sodium, phenylephrine hydrochloride, candesartan cilexetil [7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Status of Hydrogen Peroxide Solution 10 V in Commercialized Samples

Mn¹,

Ac²,

Hrn³

2017

Pharm Anal Acta

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Hydrogen peroxide (H 2 O 2 ) is one of the most powerful oxidants used in many sectors. Analytical method such as titration by permanganometry is used to maintain the quality of products containing H 2 O 2 . Thus, the objective of this work was to evaluate commercial samples of H 2 O 2 10 V by permanganometry. A difference of almost 3 volumes was found in the analysis of the samples. These results can be real or assigned to the potassium permanganate solution, not automation of the results and/or instability of the H 2 O 2 solutions, for example. The main issue is, in addition to alerting the consumers to adequate storage of H 2 O 2 solutions, to alert the scientific community to the need for concomitant analysis methods for unstable products such as H 2 O 2 10 V solutions in order to avoid doubts on the results and make the manufacturers aware of these quality tests.

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Use of an Oxidation Reaction for the Quantitative Determination of Albendazole with Chloramine-T and Acid Dyes

Cited by 22 publications

References 30 publications

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Simple and practicable methods for the determination of astemizole in pharmaceuticals using bromate-bromide and two dyes

Application of silver nanoparticles for the spectrophotometric determination of three benzimidazole anthelmintic drugs in their pharmaceutical preparations

Status of Hydrogen Peroxide Solution 10 V in Commercialized Samples

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