Application of silver nanoparticles for the spectrophotometric determination of three benzimidazole anthelmintic drugs in their pharmaceutical preparations

Abstract

This article describes the application of silver nanoparticles (AgNPs) as a colorimetric probe for the simple and selective determination of three anthelmintic benzimidazole drugs namely; albendazole, flubendazole and mebendazole. The method was based on the AgNPs aggregation induced by their interaction with the cited drugs. This interaction produced a color change from yellow to blue and accompanied by the appearance of a new surface plasmon resonance peak of AgNPs measured in the range of 615 -630 nm. The linear concentration ranges of the method were 2.0-9.0, 2.0-10 and 2.2-15 g mL -1 (r 2 = 0.9939, 0.9950 and 0.9938) for the studied drugs respectively. The validation of the analytical performance of the method was carefully investigated, and the results were satisfactory. This method was applied successfully to determine the three benzimidazoles in their pharmaceutical samples (tablets and suspensions) with high accuracy and precision. The suggested procedure is characterized by its simplicity since it does not involve solvent extraction or any critical reaction conditions.

Multifunctional green silver nanoparticles in pharmaceutical and biomedical applications

“…Indeed, the production of low-cost, energy-efficient, and nontoxic Ag nanoparticles using plant extracts, algae and microorganisms have been reported (8). The literature survey revealed a significant role of AgNPs in different fields of our life, such as catalysis (9)(10)(11), optoelectronics (12), drug analysis (13,14) and biomedical applications (15)(16)(17)(18). Also, AgNPs at very low concentration were addressed to be nontoxic to human without any side effects and have highly antimicrobial activity (19).…”