Multifunctional green silver nanoparticles in pharmaceutical and biomedical applications

Abstract

The present study concerned with the use of an aqueous ginger extract as naturally and ecofriendly reducing and stabilizing agent in the synthesis of silver nanoparticles (AgNPs). The unique physicochemical characteristics of green synthesized AgNPs exhibit high potential antimicrobial activity and displayed an impact role in pharmaceutical determinations. To confirm the nanoscale of green synthesized AgNPs, various microscopic and spectroscopic techniques were performed. The synthesized nanoparticles were screened for their antimicrobial activity against several strains of bacteria and fungi. The obtained results showed excellent bactericidal and fungicidal effects. Also, the spectrofluorimetric analysis of anastrozole drug in bulk powder and dosage form was investigated. The suggested method displayed linear relationship between the drug concentrations and the fluorescence intensity between 2 and 100 µgmL −1 with regression equation was I FL = 9.1917C+ 65.945, n = 10 and r = 0.9995 at λ ex 390 and λ em 440 nm. The green synthesized AgNPs using ginger extract demonstrated a potential activity in pharmaceutical and biomedical fields.

Green Route Synthesis and Characterization Techniques of Silver Nanoparticles and Their Biological Adeptness

“…The use of Cocos nucifera in the green synthesis of AgNPs has been described previously by Uddin et al 85 It can be noted from the results that three significant peaks occurred in the spectra at 3450, 1645, and 1089 cm –1 . Furthermore, Al Masoud et al 86 demonstrated the use of FTIR to detect biomolecules for reducing Ag + ions and capping the ginger-extract-produced bioreduced AgNPs ( Figure 7 ). The findings from this study showed that the functional groups can be detected from the synthesized AgNPs, and significant peaks can be detected at 1057, 1386, 1620, and 3417 cm –1 , which corresponded to primary alcohols and NO 3 , and C–N stretching vibrations of aliphatic and aromatic amines, respectively, can be detected.…”

“… Infrared spectra of ginger extract (A) and silver nanoparticles produced using ginger extract (B) (reprinted with permission from ref ( 86 )). …”

“…In another study, in which Al Masoud et al prepared green NPs from ginger, an absorbance peak was observed at 434 nm ( Figure 11 ). 86 …”

“… Absorption spectra of produced AgNPs in the ultraviolet–visible range utilizing ginger extract (reprinted with permission from ref ( 86 )). …”

Myrrh mixed with silver nanoparticles demonstrates superior antimicrobial activity against Porphyromonas gingivalis compared to myrrh and silver nanoparticles alone

“…This suspension alone is the AgNP suspension (SN). This suspension was then placed on an electric heater and magnetic stirrer at 60° C until a yellowish color was observed, indicating the formation of silver nanoparticles ( AlMasoud et al, 2020v , Alomar et al, 2020 ). This suspension was stored in a conical glass flask covered with foil at room temperature until use, as studies show the suspension remains stable under these conditions ( AlMasoud et al, 2020v , Alomar et al, 2020 ).…”