Spectrophotometric determination of microgram amounts of amines with chloranil

Al-Ghabsha, Thabit S.; Rahim, S.A.; Townshend, Alan

doi:10.1016/s0003-2670(01)82997-4

Cited by 42 publications

(8 citation statements)

References 4 publications

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“…The stability constant of the 1:2 TCNQ complex was determined [19,20] by comparing the absorbance of a solution containing stoichiometric amounts of TCNQ and the ciprofloxacin with that of a solution containing the same amount of the ciprofloxacin but a five-fold excess of TCNQ under the optimal reaction conditions. This was found to be 3.62x10Slmo1-1 and consequently the standard free energy change is 11.75 kcal.…”

Section: Resultsmentioning

confidence: 99%

Spectrophotometric determination of ciprofloxacin in pure form and in tablets through charge-transfer complexation reactions

et al. 1998

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Abstract. Three simple, quick and sensitive spectrophotometric methods are described for the determination of ciprofloxacin. The methods are based on the reaction of this drug as an n-electron donor with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), 7,7,8,8, -tetracyanoquinodimethane (TCNQ) and p-chloranil (CL) as 7r-acceptors to give highly coloured complex species. The coloured products are quantitated spectrophotometrically at 460, 843 and 550 nm for DDQ, TCNQ and CL, respectively. Optimization of the different experimental conditions is described. Beer's law is obeyed in the concentration ranges 5-50, 1.5-15 and 20-200 gg ml-t ciprofloxacin, but the concentration ranges for best accuracy are 10-48, 2.5-15 and 35-195 ~tg ml -t of drug for DDQ, TCNQ and CL, respectively. The relative standard deviations are less than 1.5%. Applications of the suggested methods to ciprofloxacin tablets are presented and compared with the USP method. The stability constants of the 1:1 DDQ and CL complexes were 1.086x104 and 2.581• 1041mot -t, respectively, whereas for the 1:2 TCNQ complex it was 3.62x 108 lmo1-1.

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Section: Resultsmentioning

confidence: 99%

Spectrophotometric determination of ciprofloxacin in pure form and in tablets through charge-transfer complexation reactions

et al. 1998

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“…Because the reaction of chloranil is known to be slow (29,30,32), the effect of time and temperature on the development of complexes was investigated. Maximum absorbance for the colored complexes was attained on leaving the reactant mixture in a thermostated water bath a t 40' for 45 min (l), at 25' for 30 min (II), at 40' for 15 min (111), and at 60' for 10 min (IV).…”

Section: Scheme Imentioning

confidence: 99%

Utility of Chloranil in Assay of Naphazoline, Clemizole,Penicillin G Sodium, and Piperazine

Belal

Elsayedx

Abdel-Hamid

et al. 1981

Journal of Pharmaceutical Sciences

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“…The charge transfer (CT) complex formation reactions have been used in the spectrophotometric determination of amines as n-donor using various π-acceptors such as p-chloranil (4)(5)(6) , p-fluoranil (7) , p-bromanil (8) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone(DDQ) (9) . The reaction between 1-fluoro-2,4-dinitrobenzene (10) or 1-chloro-2,4-dinitrobenzene (11) and aliphatic amines have also been studied.…”

Section: Introductionmentioning

confidence: 99%

The Use of 2,3-dichloro-1,4-naphthaquinone for the Spectrophotometric Determination of Some Primary Aliphatic Amines in Aqueous Solution

Al-Ghabsha¹,

Al-Sabha²,

Al-Neaimy³

2009

J.Edu.Sci.

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1 . ‫يقة‬ ‫الطر‬ ‫تطبيق‬ ‫تم‬ ‫لقد‬ ‫الصيدالني‬ ‫ه‬ ‫مستحضر‬ ‫في‬ ‫أمين‬ ‫ايثانول‬ ‫تقدير‬ ‫في‬ ‫بنجاح‬ . AbstractA simple and accurate spectrophotometric method was developed for the quantitative determination of some primary aliphatic amines in aqueous solution, i.e. ethanolamine, n-butylamine and n-hexylamine. The method is based on the interaction of these amines in aqueous medium with 2,3-dichloro-1,4-naphthaquinone (DClNQ) reagent in the presence of bicarbonate buffer solution to form an orange coloured products measurable at maximum wavelength of 475 nm. Beer's law is obeyed over the concentration range of 1-30, 5-20 and 3-30g/ml for The Use of 2,3-dichloro-1,4-naphthaquinone for the Spectrophotometric … 44 ethanolamine, n-butylamine and n-hexylamine respectively. The DClNQ products were formed in the ratio of 1:1 amine: DClNQ, and their stability constants were ranged between 1.9210 5 and 4.1410 5 L.mol -1 . The method was successfully applied for the determination of ethanolamine in its pharmaceutical preparation.

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Spectrophotometric determination of microgram amounts of amines with chloranil

Cited by 42 publications

References 4 publications

Spectrophotometric determination of ciprofloxacin in pure form and in tablets through charge-transfer complexation reactions

Spectrophotometric determination of ciprofloxacin in pure form and in tablets through charge-transfer complexation reactions

Utility of Chloranil in Assay of Naphazoline, Clemizole,Penicillin G Sodium, and Piperazine

The Use of 2,3-dichloro-1,4-naphthaquinone for the Spectrophotometric Determination of Some Primary Aliphatic Amines in Aqueous Solution

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