Spectrophotometric Determination of Pipazethate Hydrochloride in Pure Form and in Pharmaceutical Formulations

El-Shiekh, Ragaa; Amin, Alaa S.; Zahran, Faten; Gouda, Ayman A.

doi:10.1093/jaoac/90.3.686

Cited by 8 publications

(4 citation statements)

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“…Table 1 reveals that the proposed methods are more sensitive than the other reported spectrophotometric methods due to its higher molar absorptivity and low range under the Beer law limit. The proposed methods are also easier to perform and use inexpensive reagent and readily available compared to many reported technique [12,[14][15][16][17][18] and do not require any expensive or toxic reagents or organic solvents [15,16]. The comparative study of the molar absorptivity indicated good sensitivity of the proposed methods which follow the order of E > A > D > B > C. The proposed methods do not require any pretreatment of the drug and tedious extraction procedure prior to its analysis.…”

Section: Comparison With Othermentioning

confidence: 99%

“…Several methods have been reported for the determination of PZT in both pure and pharmaceutical preparations, include high-performance liquid chromatographic (HPLC) [4][5][6], thin-layer chromatography (TLC) [7], gas chromatography (GC) [8], electrochemical methods [9,10], UV-spectrophotometry [11], and visible spectrophotometry [11][12][13][14][15][16][17][18][19]. However, many of the reported spectrophotometric methods suffered from one or other disadvantage like poor sensitivity, heating or extraction step, use of organic solvents, use of expensive chemical, and/or complicated experimental setup as can be seen from Table 1.…”

Section: Introductionmentioning

confidence: 99%

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Utilization of a Green Brominating Agent for the Spectrophotometric Determination of Pipazethate HCl in Pure Form and Pharmaceutical Preparations

Gouda

2013

Journal of Spectroscopy

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Five simple, accurate, and sensitive spectrophotometric methods (A-E) have been described for the indirect assay of pipazethate HCl (PZT) either in pure form or in pharmaceutical preparations. The proposed methods are based on the bromination of pipazethate HCl with a solution of excess bromate-bromide mixture in hydrochloric acid medium and subsequent estimation of the residual bromine by different reaction schemes. In the first three methods (A-C), the determination of the residual bromine is based on its ability to bleach the color of methyl orange, indigo carmine, or thymol blue dyes and measuring the absorbance at 520, 610, and 550 nm for methods A, B, and C, respectively. Methods D and E involves treating the unreacted bromine with a measured excess of iron(II), and the remaining iron(II) is complexed with 1,10-phenanthroline, and the increase in absorbance is measured at 510 nm for method D and the resulting iron(III) is complexed with thiocyanate and the absorbance is measured at 480 nm for method E. The different experimental parameters affecting the development and stability of the color are carefully studied and optimized. Regression analysis of the Beer-Lambert plots showed good correlation in the concentration ranges of 0.5-8.0 g mL −1. The apparent molar absorptivity, Sandell's sensitivity, detection and quantitation limits were evaluated. The proposed methods have been applied and validated successfully for the analysis of the drug in its pure form and pharmaceutical formulations with mean recoveries of 99.94%-100.15% and relative standard deviation ≤1.53. No interference was observed from a common pharmaceutical adjuvant. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.

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Section: Comparison With Othermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Utilization of a Green Brominating Agent for the Spectrophotometric Determination of Pipazethate HCl in Pure Form and Pharmaceutical Preparations

Gouda

2013

Journal of Spectroscopy

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“…Tadalafil relaxes the neck muscle of the bladder to relieve benign prostatic hyperplasia symptoms [ 19 ] and is chemically known as [pyrazino‐[1′,2′:1,6]pyrido[3,4‐b] indole‐1,4‐dione,6(1,3‐benzodioxol‐5‐yl)2,3,6,7,12,12a‐hexahydro‐2‐methyl‐,(6R,12aR)] [ 20,21 ] (Figure 2). Various chromatographic, [ 22–28 ] spectrophotometric, [ 29–35 ] voltammetric [ 36 ] and spectrofluorimetric analytical methods have been applied for tadalafil determination. [ 37,38 ]…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box–Behnken optimization design

et al. 2020

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This is the first study focusing solely on that determination of tadalafil in the presence of citalopram as an antidepressant drug. The determination in biological fluids of a co‐administered antidepressant drug and a sexual stimulation drug is a very critical and important step for psychotic and ischaemic heart disease patients, especially in cases of emergency and this requires therapeutic drug monitoring. A sensitive, efficient and rapid assay was selected satisfactorily and applied for simultaneous determination of citalopram and tadalafil either in their pure forms, in tablet dosage forms or in spiked human plasma. There was a large overlap for both drugs, forming the broad band found in conventional fluorescence spectra and their related synchronous fluorescence intensity. Therefore, the development of a highly sensitive second derivative synchronous fluorescence method was demonstrated that removed this overlap. The proposed method depended on measuring the amplitudes of the second derivative of synchronous fluorescence intensity at suitable wavelengths of 301 nm and 367 nm for citalopram and tadalafil at Δλ = 60 nm, respectively. Box–Behnken design as a response surface methodology was used to fit models and create an optimization process encompassing a set of factors and resulting in an optimum response value specifically designed for this method. Under optimum conditions, the linear dynamic ranges for citalopram and tadalafil estimation were 20–900 and 5–400 ng ml−1 with detection limits of 5.40 and 1.43 ng ml−1, respectively.

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“…Various analytical methods for the determination of either VAR or DAC in their pharmaceutical formulations and biological fluids have been reported. The reported analytical methods for determination of VAR include liquid chromatography , gas chromatography , atomic emission spectrometry , capillary electrophoresis , voltammetric methods and different spectroscopic methods . In addition, several methods were reported for quantitative determination of DAC either alone or simultaneously with the other newly approved drugs including different chromatographic methods , stability indicating HPLC studies in bulk and formulations , electrochemical methods , spectrofluorimetric methods and thin layer chromatographic method .…”

Section: Introductionmentioning

confidence: 99%

Pencil Graphite Electrode Decorated with Xylenol Orange Flakes for Studying Possible Pharmacokinetic Interaction Between Vardenafil and Daclatasvir

et al. 2019

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The main aim of the current work is to investigate possible pharmacokinetic interactions between vardenafil hydrochloride (VAR), which is used for the treatment of erectile dysfunction and daclatasvir dihydrochloride (DAC), which is used for the treatment of chronic hepatitis C viral infection when they are concomitantly administered. Therefore, a sensitive and selective square‐wave voltammetric method was developed and validated for simultaneous determination of VAR and DAC using disposable pencil graphite electrode (PGE) modified with xylenol orange (X.O.) flakes as an electrochemical sensor. A full investigation of the experimental parameters for obtaining the highest electroanalytical signal with sufficient resolution between the oxidation peaks of two compounds was performed. It was found that VAR and DAC were resolved on X.O./PGE with different potentials at 1.4 V and 0.9 V, respectively using Britton‐Robinson buffer (pH 2.2) and 0.1 mol L−1 KCl as a supporting electrolyte. In addition, with the aid of cyclic voltammetry, a mechanistic scheme for the oxidation behaviour of both VAR and DAC was suggested. The proposed square wave voltammetric method was successfully applied for trace quantification of VAR and DAC in male rabbits. The suggested approach shows detection and quantification limits in rabbit plasma samples of 0.06 and 0.17 μmol L−1, respectively for VAR and 0.13 and 0.39 μmol L−1, respectively for DAC. The pharmacokinetic parameters of VAR alone and in combination with DAC after oral administration to rabbits were successfully estimated. The obtained results confirm that when DAC is co‐administered with VAR, plasma concentration of VAR increases, which necessitates dose adjustment for VAR to prevent toxicological consequences in patients.

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Spectrophotometric Determination of Pipazethate Hydrochloride in Pure Form and in Pharmaceutical Formulations

Cited by 8 publications

References 0 publications

Utilization of a Green Brominating Agent for the Spectrophotometric Determination of Pipazethate HCl in Pure Form and Pharmaceutical Preparations

Utilization of a Green Brominating Agent for the Spectrophotometric Determination of Pipazethate HCl in Pure Form and Pharmaceutical Preparations

Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box–Behnken optimization design

Pencil Graphite Electrode Decorated with Xylenol Orange Flakes for Studying Possible Pharmacokinetic Interaction Between Vardenafil and Daclatasvir

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