Spectrophotometric determination of salbutamol sulphate using chlorinated quinones in the presence or absence of acetaldehyde

Bakry, Rania; Razak, Omayma Abdel; Walily, Abdel Fattah M. El; Belal, Saied

doi:10.1016/0731-7085(95)01609-0

Cited by 21 publications

(8 citation statements)

References 5 publications

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“…p-Chloranil has been used as chromogenic reagent for the determination of several drugs, such as fluoxetine and sertraline [26,27], paroxetine [27], salbutamol [28], nortriptyline [29], tranquillizers and antidepressants [30], trimetazidine dihydrochloride [31], b-adrenergic blockers [32], dicyclomine hydrochloride [33], omeprazole [34], isoprenaline and methyldopa [10]. These methods are based on the interaction between electrons donors (drugs) and p-chloranil, which acts as an electron acceptor producing intensely colored charge transfer complexes (Scheme 1) [35].…”

Section: Resultsmentioning

confidence: 99%

A simple spectrophotometric method for the determination of methyldopa using p-chloranil in the presence of hydrogen peroxide

et al. 2008

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A simple, rapid and sensitive spectrophotometric method has been developed for the determination of methyldopa in pharmaceutical formulations. The method is based on the reaction between tetrachloro-p-benzoquinone (p-chloranil) and methyldopa, accelerated by hydrogen peroxide (H 2 O 2 ), producing a violet-red compound (λmax = 535 nm) at ambient temperature (25.0 ± 0.2 0 C). Experimental design methodologies were used to optimize the measurement conditions. Beer's law is obeyed in a concentration range from 2.10 x 10 -4 to 2.48 x 10 -3 mol L -1 (r = 0.9997). The limit of detection was 7.55 x 10 -6 mol L -1 and the limit of quantification was 2.52 x 10 -5 mol L -1 . The intraday precision and interday precision were studied for 10 replicate analyses of 1.59 x 10 -3 mol L -1 methyldopa solution and the respective coefficients of variation were 0.7 and 1.1 %. The proposed method was successfully applied to the determination of methyldopa in commercial brands of pharmaceuticals. No interferences were observed from the common excipients in the formulations. The results obtained by the proposed method were favorably compared with those given by the Brazilian Pharmacopoeia procedure at 95 % confidence level.

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Section: Resultsmentioning

confidence: 99%

A simple spectrophotometric method for the determination of methyldopa using p-chloranil in the presence of hydrogen peroxide

et al. 2008

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“…Salmeterol xinafoate was determined by several methods including spectrophotometry [1][2][3][4][5][6][7], HPTLC [8], HPLC [9][10][11] and electrophoresis [12].…”

Section: Salmeterol Xinafoate (Sam)mentioning

confidence: 99%

Simultaneous Determination of Salmeterol Xinafoate and Fluticasone Propionate in Bulk Powder and SeritideDiskus using High Performance Liquid Chromatographic and Spectrophotometric Method

Samir¹,

Salem²,

Abdelkawy³

2012

Pharm Anal Acta

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Five methods were developed for simultaneous determination of Salmeterol xinafoate (SAM) and Fluticasone propionate (FLU) without previous separation. In the first method (HPLC), a reversed-phase column and a mobile phase of acetonitrile: methanol (80:20 v/v) at 0.5 mLmin-1 flow rate was used to separate both drugs and UV detection at 220 nm. Linearity was obtained in concentration ranges of 50-500 µgmL-1 for Salmeterol xinafoate Fluticasone propionate. In the second method both drugs were determined using first derivative UV spectrophotometry, with zero crossing measurement at 352 and 269.5 nm for Salmeterol xinafoate and Fluticasone propionate, respectively. The third method depends on first derivative of the ratios spectra by measurements of the amplitudes at 334 and 337.5 nm for Salmeterol xinafoate and at 225 and 231.5 nm for Fluticasone propionate. Calibration graphs were established in the range of 4-28 µgmL-1 for both Salmeterol xinafoate and Fluticasone propionate. The fourth one depend on isosbestic point at 237.5 nm, while the content of Salmeterol xinafoate was determined by measuring the absolute value of the ultraviolet curves at 343 nm, without interference from Fluticasone propionate. All the proposed methods were extensively validated. They have the advantage of being economic and time saving. All the described methods can be readily utilized for the analysis of pharmaceutical formulations. The results obtained by adopting the proposed methods were statistically analyzed and compared with those obtained by official methods.

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“…During an asthma attack, the smooth muscle Literature survey shows that several spectrophotometric [2][3][4][5][6][7][8][9][10][11][12] , spectrofluorimetric 13 , conductometric 14 , potentiometric 15 , LC-MS 16 and HPLC [17][18][19][20][21][22][23] methods reported for the determination of salbutamol sulfate in various samples. During an asthma attack, the smooth muscle Literature survey shows that several spectrophotometric [2][3][4][5][6][7][8][9][10][11][12] , spectrofluorimetric 13 , conductometric 14 , potentiometric 15 , LC-MS 16 and HPLC [17][18][19][20][21][22][23] methods reported for the determination of salbutamol sulfate in various samples.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of kinetic and atomic absorption spectrophotometric methods for the determination of salbutamol sulfate

et al. 2015

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Two sensitive kinetic and atomic absorption spectrophotometric (AAS) methodswhere developed for the determination of salbutamol sulfate (SLS) in its dosage forms. The kinetic method was based on the bromination reaction of the drug by bromine generated in-situ by the reaction of bromate with bromide in acidic medium.The reaction was followed spectrophotometrically by measuring the decrease of bromine color at 380 nm. The reaction was carefully studied and optimized. Under optimum conditions, the stoichiometry and the order of the reaction were determined.The initial rate and fixed time methods were utilized for the determination of salbutamol sulfate concentrations. The AAS method was depended on the oxidation of iron (II) with excess bromine from the bromination reaction of the drug. A new method for separation iron (III) was used. Then iron (II) in aqueous layer was aspirated into air-acetylene flame and determined by AAS. The linear ranges for the proposed methods were 2.0-10.0 and 0.2-2.0 µgmL -1 with detection limit of 0.30 and 0.012 µgmL -1 for kinetic and AAS, respectively. The proposed methods were validated; the mean recovery ranges from 98.0 to 102.0% with RSD < 2.1%. Common excipients did not interfere the measurements of SLS. The methods were successfully applied to determined SLS in dosage forms; there was no significant difference between the proposed methods and official one.

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Spectrophotometric determination of salbutamol sulphate using chlorinated quinones in the presence or absence of acetaldehyde

Cited by 21 publications

References 5 publications

A simple spectrophotometric method for the determination of methyldopa using p-chloranil in the presence of hydrogen peroxide

A simple spectrophotometric method for the determination of methyldopa using p-chloranil in the presence of hydrogen peroxide

Simultaneous Determination of Salmeterol Xinafoate and Fluticasone Propionate in Bulk Powder and SeritideDiskus using High Performance Liquid Chromatographic and Spectrophotometric Method

Development and validation of kinetic and atomic absorption spectrophotometric methods for the determination of salbutamol sulfate

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