Spectrophotometric Determination of Some Tranquillizers and Antidepressants Using 2,3-Dichloro 5,6-Dicyano-p-Benzoquinone

Abstract

Egypt ABSTRACTA simple and sensitive saectrophotometric method is described for the assay of some tranauillixers and antidepressants, namely, chlorpromaxine, imipramine, amitriptyline and chlorprothexine. The method was based on the interaction of these drugs as n-electron donors with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as -acceptor to give a highly coloured radical anion which exhibits maximum absorption at 460 nm, The radical anion was proved by electron sain resonance measurements.The proposed method has been successfully anplied for the determination of the examined drugs in tablets. The 1391 Copyight 0 1985 by Marcel Dekker, Inc.

Determinação turbidimétrica do antidepressivo amitriptilina em sistema fia explorando a formação do par iônico com lauril sulfato de sódio

“…7 Abdel-Salam e colaboradores propõem o uso do reagente 2,3 -dicloro 5, 6 diciano -p -benzoquinona (DDQ) para a avaliação do teor de ADTs, dentre eles a AMT, em formulações farmacêuticas. 8 Esses dois agentes espectrofotométricos e ainda iodo foram usados por Bebawy et al para quantificar fluoxetina e sertralina, dois antidepressivos de nova geração, mostrando a versatilidade desses agentes. 9 Entretanto, as reações com formação desses complexos ocorrem em meio orgânico, tais como uma mistura de dioxano-etanol, acetonitrila, acetona ou dicloroetano.…”

Spectrophotometric Determination of Chlorprothixene Hydrochloride by Pyrocatechol Violet and Ceric(iv) Ions

“…It is also prescribed for the treatment of alcoholic disease, neurosis and personality disorders. Reactions with chloranil [10] or 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) [11] are also used for its determination. It is easily oxidised with generation of colourless products: sulphoxide, [2,3] sulphone [4,5] or thioxantones.…”

A new spectrofluorimetric approach for the quantitation of imipramine HCl in commercial dosage forms

“…Several other analytical methods have been reported based on high performance thin layer chromatography [8], high performance liquid chromatography [9,10], electrochemical analysis [11][12][13] and spectrophotometry [14][15][16][17][18][19]. Imipramine HCl is weakly fluorescent in nature and reagents such as erythrosine B in chloroform [20] and rhodamine B in ethylene glycol-distilled water medium [21] have been utilized for quantitative determination of active drug in pharmaceutical formulations by fluorescence spectrophotometry.…”