Spectrophotometric Estimation of Metaxalone and Diclofenac Potassium by Multicomponent Analytical Method from Tablet Dosage Form

Patel, Chintan R.; Kimbahune, Ritu; Kabra, Prachi

doi:10.4172/2155-9872.1000137

Cited by 1 publication

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“…Metaxalone is one of the commonly used muscle relaxant therapies for acute low back pain 4 . Literature survey carried out revealed that several methods have been reported for estimation of metaxalone by using,, RP-HPLC Method 5,6 , HPLC , UV spectrophotometric method 10 , UV Derivative spectrophotometric method 11 , HPTLC Method 12 are available to determine metaxalone in tablet dosage form. However, there is no method reported for estimation of metaxalone in tablet dosage form by using UV spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

Analytical Method Development and Validation of Metaxalone in Bulk and Its Pharmaceutical Formulation by Uv Spectroscopic Method

Reddy¹,

Ishaq²,

Rajan³

et al. 2013

Int. Res. J. Pharm.

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Metaxalone, a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains and othermusculoskeletal conditions. A simple, accurate, precise, reproducible, highly sensitive, economic UV spectrophotometric method has been developed for the estimation of metaxalon in bulk and tablet dosage form. In this method metaxalon showed maximum absorbance at 280 nm in methanol. The developed spectrophotometric method was validated in accordance with ICH guidelines. Linearity of the method was found to be 5 -160µg/ml. The method obeyed Beer's law in the concentration range of 5 -160 µg/ml. The LOD and LOQ were found to be 3.489μg/ml and 10.575μg/ml respectively. A mean recovery of metaxalon in tablet dosage form was found to be 99.69%.the method was found to be simple, accurate, precise, specific, sensitive, reproducible and can be directly and easily applied to tablet dosage form.

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Section: Introductionmentioning

confidence: 99%