Spectrophotometric methods for the determination of prazosin hydrochloride in tablets

Sreedhar, K.; Sastry, C. S. P.; Reddy, M. N.; Sankar, D. Gowri

doi:10.1016/0039-9140(96)01951-0

Cited by 18 publications

(4 citation statements)

References 6 publications

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“…1), a selective ␣ 1 -adrenoceptor antagonist in clinical use [1][2][3], has gained a widespread acceptance in the management of hypertension and in the treatment of congestive heart failure [4,5]. However, the bioavailability of PRH is very low, which is mainly due to its low solubility in water.…”

Section: Introductionmentioning

confidence: 98%

Preparation and characterization of inclusion complexes of prazosin hydrochloride with β-cyclodextrin and hydroxypropyl-β-cyclodextrin

Liu

Zhu

2006

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 98%

Preparation and characterization of inclusion complexes of prazosin hydrochloride with β-cyclodextrin and hydroxypropyl-β-cyclodextrin

Liu

Zhu

2006

Journal of Pharmaceutical and Biomedical Analysis

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“…: NBS, being the most versatile, has been used for the spectrophotometric determination of different drugs (26)(27)(28)(29) . These methods involves two stages oxidation of the drug by NBS and the estimation of unconsumed NBS with Celestine blue (CB).…”

Section: Cefprozilmentioning

confidence: 99%

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

2010

Egypt. J. Chem.

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WO SIMPLE, accurate spectrophotometric and potentiometric m methods were developed for the determination of cefprozil, dropropizine and tizanidine hydrochloride in their pharmaceutical preparations. The spectrophotometric method is based on the selective oxidation of cefprozil or tizanidine with N-bromosuccinimide in an alkaline medium to give an intense yellow product with a maximum absorption at 396 or 384 nm, respectively. The reaction conditions were studied and optimized. The reaction obeyed Beer's law over the concentration range 5-40 and 10-80 g ml -1 for cefprozil and tizanidine hydrochloride, respectively. The potentiometric method involves the direct titration of cefprozil and dropropizine with Nbromosuccinimide in sulphuric acid medium and the end point is determined potentiometrically using platinum electrode. Cefprozil and dropropizine can be determined quantitatively in the concentration range of 0.13-1.30 and 0.118-1.180 mg with recovery values of 98.46-100.77 and 99.58-100.85% and relative standard deviations 0.39-0.54 and 0.52-0.87% for cefprozil and dropropizine, respectively. The proposed methods are applied for the determination of these drugs in pure forms and in pharmaceutical preparations.

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“…The development of sensitive analytical methods for the detection and evaluation of these drugs in human samples is highly desired because of their strong potency. A variety of different analytical methods have been reported for the determination of ALF, DOX, TER and PRA in pharmaceutical formulations and biological samples, including spectrophotometry, [3][4][5][6] fluorometry, 7,8 voltammetry, [9][10][11] high-performance liquid chromatography (HPLC) [12][13][14][15][16][17][18][19] and high-performance thinlayer chromatography 20,21 methods. Among these methods, fluorometry is considered to provide a high level of sensitivity, as well as being one of the most convenient of the different analytical techniques for pharmaceutical analysis.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Fluorescence Methods for the Determination of Alfuzosin, Doxazosin, Terazosin and Prazosin in Pharmaceutical Formulations, Plasma and Urine

Guo

Shi

et al. 2016

ANAL. SCI.

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Polymeric ionic liquid-coated magnetic nanoparticles have been successfully prepared as adsorbents for the magnetic solid-phase extraction of four drugs, namely alfuzosin, doxazosin, terazosin and prazosin, from pharmaceutical preparations, urine samples and plasma samples. The four drugs were detected by fluorescence spectrophotometer. Several extraction parameters, including the pH of the solution; the type, ratio and volume of the desorbing reagent; the amount of adsorbent; the time of the extraction and desorption processes; and the addition of NaCl, were investigated and optimized. Linear responses were determined for the four drugs in the concentration range of 0.5 - 45 ng mL(-1). The limit of detection values for alfuzosin, doxazosin, terazosin and prazosin, which were defined as three times the standard deviation of a blank sample, were determined to be 0.035, 0.034, 0.027 and 0.028 ng mL(-1) (n = 11), respectively. Furthermore, this new method gave preconcentration factors of 114.5, 111.3, 111.1 and 108.5 for these four drugs.

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Spectrophotometric methods for the determination of prazosin hydrochloride in tablets

Cited by 18 publications

References 6 publications

Preparation and characterization of inclusion complexes of prazosin hydrochloride with β-cyclodextrin and hydroxypropyl-β-cyclodextrin

Preparation and characterization of inclusion complexes of prazosin hydrochloride with β-cyclodextrin and hydroxypropyl-β-cyclodextrin

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

Highly Sensitive Fluorescence Methods for the Determination of Alfuzosin, Doxazosin, Terazosin and Prazosin in Pharmaceutical Formulations, Plasma and Urine

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