Spectrophotometric Simultaneous Determination of Valsartan and Amlodipine Besylate in Combined Capsule Dosage form by Ratio Derivative Method

Chabukswar, Aniruddha R.; Kolsure, Anuja; Kuchekar, B. S.; Jagdale, Swati

doi:10.18579/jpcrkc/2010/9/4/79504

Cited by 11 publications

(8 citation statements)

References 3 publications

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“…The seven drugs were successfully resolved and quantified in a reasonably short run time (less than 15 min) using a regular inexpensive RP‐C8, a simple mobile phase with isocratic elution and DAD measurement at a single wavelength. Obviously, the proposed method is advantageous to most of the previously reported methods for analysis of DPX mixtures with SIL, TAD, or VAR regarding selectivity and/or sensitivity of measurement. The proposed method met the ICH validation criteria concerning linearity, ranges, precision, accuracy, and robustness.…”

Section: Discussionmentioning

confidence: 99%

“…Few analytical methods were reported for some PDE‐5 inhibitor/SSRI binary combinations. The simultaneous determination of SIL and DPX was carried out using spectrophotometric and RP‐HPLC methods . Additionally, a couple of HPLC with UV detection procedures and HPLC with fluorescence detection were described for the simultaneous estimation of TAD and DPX.…”

Section: Introductionmentioning

confidence: 99%

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High-performance liquid chromatography with diode array detection method for the simultaneous determination of seven selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors used as male sexual enhancers

et al. 2016

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This work presents a simple, sensitive and generic high-performance liquid chromatography with diode array detection method for the simultaneous determination of seven drugs prescribed for the treatment of erectile dysfunction and premature ejaculation. Investigated drugs include the phosphodiesterase-5 inhibitors: sildenafil, tadalafil, and vardenafil, in addition to the selective serotonin reuptake inhibitors: dapoxetine, duloxetine, fluoxetine, and paroxetine. The drugs were separated using a Waters C8 column (4.6 × 250 mm, 5 μm) with the mobile phase consisting of phosphate buffer pH 3, acetonitrile and methanol in the ratio 60:33:7. The flow rate was 1.2 mL/min, and quantification was based on measuring peak areas at 225 nm. Peaks were perfectly resolved with retention times 3.3, 3.9, 6.4, 7.5, 9.5, 10.7, and 13.4 min for vardenafil, sildenafil, paroxetine, duloxetine, dapoxetine, fluoxetine, and tadalafil, respectively. The developed method was validated with respect to system suitability, linearity, ranges, accuracy, precision, robustness, and limits of detection and quantification. The proposed method showed good linearity in the ranges 5-500, 2-200, 2-200, 3-300, 1.5-150, 2-200, and 2-200 μg/mL for sildenafil, tadalafil, vardenafil, dapoxetine, duloxetine fluoxetine, and paroxetine, respectively. The limits of detection were 0.18-0.38 μg/mL for the analyzed compounds. The applicability of the proposed method to real life situations was assessed through the analysis of commercial tablets, and satisfactory results were obtained.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High-performance liquid chromatography with diode array detection method for the simultaneous determination of seven selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors used as male sexual enhancers

et al. 2016

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“…So, there is not any official method described for their estimation. It is estimated by spectrophotometry [2][3][4], HPLC [5,6], fluorescence spectroscopy [7], and TLC [8] methods. Literature review shows that no potentiometric method has been reported so far for its estimation although ISEs have been used extensively for drug analysis over the last decades.…”

Section: Dap (Dapoxetine Hcl) Is Designated Chemically As (S)-nmentioning

confidence: 99%

Electrochemical Determination of Dapoxetine HCl in Biological Fluids Using Coated Wire Electrod

Alturiqi¹

2016

JCCE

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Coated wire sensor for potentiometric determination of DAP (dapoxetine HCl) in pure form and in biological fluids based on DAP-TPB (dapoxetine-tetraphenyl borate) as the sensing element in the presence of DOP (dioctylphthalate) as the plasticizing solvent mediator was prepared. The best performance was obtained with a membrane composition of 10.0% (w/w) ion-pair, 45.0% DOP (w/w) and 45.0% PVC (w/w). The electrode showed a Nernstian response (with a slope of 58.70 mV decade -1 ) for the concentration range of 4.2 × 10 −5 -1.0 × 10 −2 mol/L. It illustrates a relatively fast response time in the whole concentration range (~15 s) in a pH range of 3.0-7.5 . The selectivity coefficients were determined in relation to several inorganic and organic species. DAP is determined successfully in pure solutions and in biological fluids using the standard additions and potentiometric titrations methods.

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“…18 For VAL, UV spectrophotometry, [19][20][21][22] HPLC, 19,23 and HPTLC 24 methods were reported. Published methods for simultaneous determination of AMD and VAL include UV spectrophotometric, [25][26][27][28][29][30][31][32][33][34][35][36] spectrofluorimetric methods [37][38][39] , HPLC, 25,30,31,[40][41][42][43][44][45][46][47] TLC 44,48 and capillary electrophoresis. 49,50 The present research work is concerned with the development of two simple, accurate and sensitive spectrophotometric methods: absorption correction method (ACM) and dual wavelength method (DWM) for simultaneous determination of AMD and VAL with no need for prior separation.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Amlodipine and Valsartan in Pharmaceutical Dosage Form

El‐Malla

Hammad

Khashaba

2021

Journal of Advanced Medical and Pharmaceutical Research

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Two simple spectrophotometric methods had been developed for simultaneous determination of amlodipine (AMD) and valsartan (VAL) in their tablet dosage form. These methods include absorption correction method and dual wavelength method. The first method was based on the measurement of absorbance at 360 nm for AMD and 257.1 nm for VAL, while the second depended on measuring the absorbance difference (A) in zero order spectra between (226.5-250 nm) for determination of VAL while AMD was determined directly by measuring absorbance at 360 nm. Both methods were validated according to International Council for Harmonisation (ICH) guidelines. The linearity range was found to be 8-25 μg/mL for determination of AMD and 6-35 μg/mL for determination of VAL. The methods were successfully applied for the simultaneous determination of AMD and VAL in the commercially available Exforge ® tablets. The average values of percent recovery  standard deviation was found to be consistent with the label claim of the dosage form. The results were also compared to a reported method using t-test and F-test at confidence level of 95%, no significant differences were observed. The presented methods permit simple, rapid, and direct determination of AMD and VAL in commercially available combined dosage form using zero-order UV spectra without previous separations and were suitable for routine analysis.

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Spectrophotometric Simultaneous Determination of Valsartan and Amlodipine Besylate in Combined Capsule Dosage form by Ratio Derivative Method

Cited by 11 publications

References 3 publications

High-performance liquid chromatography with diode array detection method for the simultaneous determination of seven selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors used as male sexual enhancers

High-performance liquid chromatography with diode array detection method for the simultaneous determination of seven selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors used as male sexual enhancers

Electrochemical Determination of Dapoxetine HCl in Biological Fluids Using Coated Wire Electrod

Quantitative Determination of Amlodipine and Valsartan in Pharmaceutical Dosage Form

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