Spectrophotometric study of quercetin in metallomicellar solutions of 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complex with copper dibromide

Zhil’tsova, E. P.; Ibatullina, M. R.; Лукашенко, С. С.; Кутырева, М. П.; Zakharova, L. Ya.

doi:10.1016/j.molliq.2017.11.091

Cited by 14 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…43 Complexes 1 and 2 were synthesized in methanol and acetone by the procedure. 34,36 The compositions of the products were confirmed by IR and 1 H NMR spectroscopy, elemental analysis, and for the crystals of metallocomplex 1 by single-crystal XRD (in Figure S6). 31 La(NO 3 ) 3 •6H 2 O (98%) (Acros-Organics, USA) was used as received.…”

Section: ■ Conclusionmentioning

confidence: 96%

“…22,34,35 In addition, the spectrophotometric method showed that supramolecular systems based on metallocomplexes exhibit high solubilization activity with respect to the hydrophobic agent Orange OT dye, 30,31 as well as poorly soluble drugs quercetin and furadonin. 36,37 This allows us to achieve a significant increase in the content of drugs in an aqueous medium (up to 1−2 orders of magnitude) and thereby increase their bioavailability. In addition, a biologically important property of the studied metallosurfactants is their ability to complex with biomolecules (oligonucleotide), 35 as well as the manifestation of antimicro-bial and antifungal activity.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Previous tensiometric, conductometric, and fluorimetric studies showed that these metal complexes were micelle-forming surfactants. Moreover, their aggregation ability was higher than that of the D 16 Br ligand and conventional surfactants with the head group of acyclic and monocyclic types (cetyltrimethylammonium bromide and cetylpyridinium bromide). ,, In addition, the spectrophotometric method showed that supramolecular systems based on metallocomplexes exhibit high solubilization activity with respect to the hydrophobic agent Orange OT dye, , as well as poorly soluble drugs quercetin and furadonin. , This allows us to achieve a significant increase in the content of drugs in an aqueous medium (up to 1–2 orders of magnitude) and thereby increase their bioavailability. In addition, a biologically important property of the studied metallosurfactants is their ability to complex with biomolecules (oligonucleotide), as well as the manifestation of antimicrobial and antifungal activity. , A wide range of functional applications of metallosurfactants require a deeper study of their structural and physicochemical features, as well as functional activity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Self-Assembling Metallocomplexes of the Amphiphilic 1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development of Nonplatinum Anticancer Drugs

et al. 2022

Self Cite

View full text Add to dashboard Cite

New 1-cetyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complexes with copper(II) bromide and lanthanum(III) nitrate were characterized using dynamic light scattering and transmission electron microscopy, with self-assembly and the morphological behavior elucidated. For the lanthanum(III) nitrate complex, the 3D crystal structure was characterized using X-ray diffractometry. These metallosurfactants were tested as antitumor agents, and a high cytotoxic effect comparable with doxorubicin was revealed against the M-HeLa and A-549 cell lines. Both complexes were 2 times more active toward the MCF-7 cell line than the breast cancer drug tamoxifen. The cytotoxic mechanism of complexes is assumed to be related to the induction of apoptosis through the mitochondrial pathway.

show abstract

Section: ■ Conclusionmentioning

confidence: 96%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Self-Assembling Metallocomplexes of the Amphiphilic 1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development of Nonplatinum Anticancer Drugs

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Системы на основе МПАВ меди и лантана использованы для увеличения растворимости, а следовательно, и биодоступности, труднорастворимых препаратов кверцетина [76], нитрофурантоина [77] и гризеофульвина [78]. В случае кверцетина металломицеллярные растворы комплекса [ДАБКО-16×CuBr 2 ] позволили до 270 раз повысить его содержание в воде.…”

Section: металломицеллярные системы на основе комплексов алкилированнunclassified

Polyfunctional Nanosystems on Amphiphilic and Hybrid Platform: Self-Assembly, Mesogenic Properties and Application

Zhil’tsova¹,

Ibatullina²,

Mirgorodskaya³

et al. 2020

Liq. Cryst. and their Appl.

View full text Add to dashboard Cite

Обзор посвящен анализу современных публикаций в области самоорганизации амфифильных соединений, формирования полифункциональных наносистем различной морфологии, их прикладного потенциала в нано-и биотехнологиях. Рассмотрены самоорганизующиеся системы на основе амфифильных соединений, преимущественно катионных ПАВ, а также на гибридной платформе металл/амфифил. Для серии катионных ПАВ проведен анализ влияния структуры головной группы на функциональную активность (солюбилизирующие, каталитические, антимикробные свойства). Продемонстрированы перспективы их использования в качестве мицеллярных наноконтейнеров для гидрофобных спектральных зондов и лекарственных средств, невирусных векторов и антимикробных препаратов. Обсуждены гибридные системы на амфифильной платформе, в том числе металломицеллярные композиции, включающие металлы различной природы, установлена корреляция структура-активность при варьировании структуры ПАВ и природы металла. Отдельный раздел посвящен металломезогенам на амфифильной платформе, разработке наноматериалов различного назначения на их основе, применению в биомедицине, оптике, катализе. Спецификой таких систем является комбинация свойств, типичных для ПАВ (самоорганизация и поверхностная активность), и особенностей, характерных для координационных соединений (окислительно-восстановительные, каталитические, магнитные и оптические свойства). Введение иона металла может способствовать увеличению температурного интервала и концентрационной области существования мезофаз. Дополнительные возможности расширения морфологического поведения и функциональной активности предоставляет использование макроциклической матрицы, позволяющей создавать новые жидкокристаллические материалы.

show abstract

“…antitumor effect, antiviral effect, antithrombotic effect, anti-inflammatory effect, antiallergic effect, protection effect from atherosclerosis and coronary heart diseases [2,3].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of new solid phase sorbent for sensitive spectrophotometric determination of Quercetin

Ulusoy

2021

Cumhuriyet Science Journal

View full text Add to dashboard Cite

Sensitive and easy applicable analysis of Quercetin molecules was executed whereby solid phase extraction (SPE) and molecular spectrophotometric determination. For the determination of quercetin, an accurate, economical, time-saving and a new environmentally friendly method has been developed with a simple spectrophotometer device available in every laboratory. As a solid-phase sorbent, a new polymer nanocomposite has been synthesized and characterized by Fouirer Transform Infrared Spectroscopy (FT-IR) and Scanned Electron Microscopy (SEM). Experimental solid phase extraction variables have been investigated and optimized step by step, such as pH, adsorption time and desorption conditions, etc. According to optimization results, desorption of quercetin molecules was carried out by 2-propanol solvent and absorbance of eluent solutions were measured as systematic at 255 nm and at 370 nm. However, the best results were obtained at 370 nm wavelength. Therefore, all measurements were made at 370 nm. (LOD) means that the detection limit and (LOQ), the quantitation limit values for quercetin were calculated as 5.97 ng mL -1 and 17.91 ng mL -1 , respectively. Standard addition and recovery experiments were performed as an indicator of the accuracy of the method. The method developed was effectively conducted to model solutions.

show abstract

Spectrophotometric study of quercetin in metallomicellar solutions of 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complex with copper dibromide

Cited by 14 publications

References 42 publications

Self-Assembling Metallocomplexes of the Amphiphilic 1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development of Nonplatinum Anticancer Drugs

Self-Assembling Metallocomplexes of the Amphiphilic 1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development of Nonplatinum Anticancer Drugs

Polyfunctional Nanosystems on Amphiphilic and Hybrid Platform: Self-Assembly, Mesogenic Properties and Application

Synthesis of new solid phase sorbent for sensitive spectrophotometric determination of Quercetin

Contact Info

Product

Resources

About