Spectroscopic analysis of charge transfer complexes between morpholine and iodine.

Lagorce, Jean F.; Jambut-Absil, Anne-Catherine; Buxeraud, Jacques; Mœsch, Christian; Raby, C

doi:10.1248/cpb.38.2172

Cited by 12 publications

(4 citation statements)

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“…The equilibrium (1) using 1 as a donor has already been investigated in solution [14]. Besides 2, we have also studied N-methylmorpholine (3) to introduce further details in studying the reactivity of these compounds in solution.…”

Section: CMmentioning

confidence: 99%

Interaction of morpholine and thiomorpholine with molecular diiodine:X-ray crystal structure of morpholinium triiodide

et al. 1997

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Section: CMmentioning

confidence: 99%

Interaction of morpholine and thiomorpholine with molecular diiodine:X-ray crystal structure of morpholinium triiodide

et al. 1997

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“…K c was determined using Lang's method, 15 which has been successfully used to determine the formation constants of 1:1 stoichiometric complexes,…”

Section: Resultsmentioning

confidence: 99%

Antithyroid activity of 6-chloropurine

Fatima¹,

Munawar²,

Khan³

et al. 2010

J. Braz. Chem. Soc.

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A atividade antitireóidea do 6-cloropurina, in vitro, foi determinada espectrofotometricamente por estudos de formação de seu complexo com iodo. O complexo mostrou estequiometria de 1:1. A constante de formação do complexo encontrada foi 7,652 × 10 3 L mol -1, o que indicou um bom potencial de 6-cloropurina, como agente antitireóideo. Posteriores verificações mostraram mudanças nos níveis hormonais tireóideos em coelhos machos, in vivo, após administração da dose via intraperitoneal (i.p.) durante 14 dias e medindo os níveis de triiodotironina (T 3 ) e tetraiodotironina (T 4 ) livres, na circulação sanguínea, usando-se a técnica de radioimunoensaio. As análises de sangue mostraram decréscimo nos níveis de T 3 e T 4 livres em animais tratados, quando comparados com os controles. Desta maneira, confirmou-se uma boa atividade antitireóidea do 6-cloropurina.Antithyroid activity of 6-chloropurine was determined, in vitro, by studying its complex formation with iodine spectrophotometrically. The complex exhibited a 1:1 stoichiometry. Formation constant (K c ) of the complex was found to be 7.652 × 10 3 L mol -1, which indicated good antithyroid potential of 6-chloropurine. For further verification, changes in the thyroid hormone levels of the male rabbits were observed, in vivo, after administering the dose through intra peritoneal (i.p.) injections for 14 days and measuring free triiodothyronine (T 3 ) and tetraiodothyronine (T 4 ) levels in the blood serum using radioimmunoassay technique. The blood assays showed decrease in free T 3 and T 4 levels in the treated animals as compared to the control ones thus confirming fairly good antithyroid activity of 6-choloropurine.

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“…The anti‐thyroid activity was evaluated using Lang's method [35] . The BS/I 2 stoichiometry was assessed by fluorescence spectroscopy.…”

Section: Methodsmentioning

confidence: 99%

“…The anti-thyroid activity was evaluated using Lang's method. [35] The BS/I 2 stoichiometry was assessed by fluorescence spectroscopy. The formation constant (Kc) and the molar extinction coefficient were determined using the method employed for determining the formation constants of a 1 : 1 stoichiometric complex.…”

Section: Methodsmentioning

confidence: 99%

Phosphatase Alkaline Inhibition and Antithyroid Activity of Acetylacetone Sulfonamide Derived Schiff Base. In Vitro and In Silico Studies

Gaddi,

Caro‐Ramírez,

Antonena

et al. 2024

ChemistrySelect

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The sulfonamide‐derived compounds have demonstrated various pharmaceutical properties. However, the exploration of certain properties, such as phosphatase inhibition and anti‐thyroid activities, has been limited in the existing literature. The present study aimed to investigate these specific activities for the Schiff base (Z)‐4‐(4‐oxopent‐2‐en‐2‐ylamino)benzenesulfonamide. The compound underwent thorough physicochemical characterization, including FTIR, Raman, and UV‐Vis spectroscopy, along with theoretical DFT calculations. It exhibited inhibitory activity against intestinal alkaline phosphatase, showing an IC50 value of 37.0±1.0 μM, with kinetic studies indicating a mixed mode of inhibition. Additional insights into the inhibition process were gained through fluorescence spectroscopy and molecular docking studies. The potential anti‐thyroid activity was explored through charge‐transfer studies with iodine, revealing a strong interaction (Kc=2.16±0.05×104 M−1), suggesting a role in reducing the iodination process of triiodothyronine (T3) and thyroxine (T4). Moreover, the compound showed strong, spontaneous, and reversible binding to albumin, indicating potential pharmaceutical relevance. ADME properties were also calculated, confirming favorable drug‐likeness. This study provides valuable insights into the multifaceted pharmaceutical properties of the investigated sulfonamide‐derived compound, encouraging further exploration of its therapeutic potential.

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Spectroscopic analysis of charge transfer complexes between morpholine and iodine.

Cited by 12 publications

References 0 publications

Interaction of morpholine and thiomorpholine with molecular diiodine:X-ray crystal structure of morpholinium triiodide

Interaction of morpholine and thiomorpholine with molecular diiodine:X-ray crystal structure of morpholinium triiodide

Antithyroid activity of 6-chloropurine

Phosphatase Alkaline Inhibition and Antithyroid Activity of Acetylacetone Sulfonamide Derived Schiff Base. In Vitro and In Silico Studies

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