Spectroscopic and Biocidal Study of Co(II), Cu(II) and Ni(II) Chelates of Nitrogen and Sulphur Containing Schiff Base Derived from 6-methyl-2-phenyl-4H-chromen-4-one

Abstract

INTRODUCTIONSchiff bases have the ability to act as coordinating ligands and the polynuclear complexes derived from Schiff bases find variety of applications in analytical and biological systems [1][2][3][4][5][6][7][8][9][10][11][12] . Schiff base complexes of transition metals are of great interest and have extensively been studied over past few decades [13][14][15][16] ABSTRACTIn the present paper, a series of complex of the type [MLX 2 ] where M = Co(II), Ni(II) and Cu(II), L = 6-methyl-2-phenyl-4H-chromen 4-thisemicarbazone (MPCT) have been synthesized. Their structure were confirmed by means of IR, electronic spectra, elemental analysis and molar conductance, coupled with magnetic susceptibility measurements. All the compounds were assayed for antibacterial activities against one gram positive bacterial strain Bacillus subtilis and one gram negative bacterial strain Eschericpia coli, using disc diffusion technique. It was observed on comparison with reference to antibiotic and fungicides. The complexes were found to be more effective than ligands. Schiff base coordination compounds, the present work was undertaken to study the complexes of Co(II), Ni(II) and Cu(II) ions with bioactive ligands. In the present paper, we report a series of new Co(II), Ni(II) and Cu(II) complexes of Schiff base 6-methyl-2-phenyl-4H-chromen-4-thiosemicarbazone. The complexes have general molecular formula [MLX 2 ]; where M = Co(II), Ni(II) and Cu(II); L = 6-methyl-2-phenyl-4H-chromen-4-thiosemicarbazone (MPCT) and X = Cl -, Br -, I -and NO 3 -.

A Pharmaceutical Approach & Antifungal Activities of Copper Soaps with their N & S Donor Complexes Derived from Mustard and Soyabean Oils

“…The Bordeaux mixture [1]. (Copper sulphate and hydrated lime) was the first fungicide to be used on a large scale world-wide [2,3]. Recent studies conducted showed that the use of copper significantly reduced the numbers of bacteria, filamentous fungi and yeast on leaf and fruit surfaces [4].…”

Surface Active Properties of Some Bioactive Azole Series Complexes of Copper in Binary Solvent Mixture

“…It is endowed with multiple applications like antihistamine activity, pharmacological activities such as antifungal, antiinflammatory, antimicrobial, anticonvulsant, antitumor, anticancer etc. It shows increased potency upon complexation with copper soaps [1][2][3][4][5][6][7][8][9] .…”