Spectroscopic and physical–chemical characterization of ambazone–glutamate salt

Abstract

Abstract. Ambazone monohydrate C 8 H 11 N 7 S · H 2 O (AMB), a well-known antimicrobial compound, was used together with Glutamic Acid C 5 H 9 NO 4 (Glu) to obtain a new solid form using the solvent-drop grinding procedure. The screening of the new solid form was best achieved by the combined use of X-ray Powder Diffraction (XRPD) and several spectroscopic techniques (Fourier Transformed Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), Raman and 13 C-NMR spectroscopy) together with Differential Scanning Calorimetry (DSC), Differential thermal analysis and thermogravimetry (DTA-TGA). The combination of the mentioned analytical techniques allows the compound to be assigned to an ambazone-glutamate salt which crystallizes in monoclinic system having the following lattice parameters: a = 9.8352, b = 4.7014, c = 40.0987 Å and β = 94.505• . DSC, TGA data and the before mentioned spectroscopic techniques support the ambazone-glutamate salt formation.

A New Thermodynamically Favored Flubendazole/Maleic Acid Binary Crystal Form: Structure, Energetics, and in Silico PBPK Model-Based Investigation

“…The Δ BE = 2.4 eV increase of the binding energy of N7 on going from pure FBZ to FBZ/MA indicates a decrease in the electron density of the imine environment, which can be explained by the occurrence of proton transfer from MA to FBZ leading to salt formation. A similar behavior has been reported for salts of ambazone 49 and lapatinib. 50 Since nitrogen is only present in the FBZ moiety and the protonation happens on the amino group, this effect is readily detectable in the N 1s spectra.…”

Methoxy-modified kaolinite as a novel carrier for high-capacity loading and controlled-release of the herbicide amitrole

“…2d ), the intensities of the three inner-surface hydroxyl groups were substantially decreased, indicating the AlOH groups were further consumed during the intercalation of AMT. The new vibration bands at 3475 and 3375 cm −1 , occurring in the DRIFT spectrum of AMT-Kaol MeOH are assigned to the stretching vibration of the protonated amino group 15 16 , which formed via the proton transfer from the inner-surface AlOH groups of kaolinite to the amino groups of AMT. Therefore, the interaction between the intercalated AMT and the methoxy-modified kaolinite is an electrostatic attraction, which is stronger than the hydrogen bonding in AMT-Kaol.…”

Co-Crystals of Etravirine by Mechanochemical Activation

“…41 Additional information on the structure of the synthesized samples and on the elemental composition and chemical environment, were obtained by XPS analysis. 19,45,46 (Fig. 6)…”