Spectroscopic and potentiometric studies of the interaction of adenine with trivalent metal ions

Hamada, Yahia Z.; Greene, Jasmine; Shields, Veronica; Pratcher, Monique; Gardiner, Shandera; Waddell, Emanuel; Shreeves, Stephen; Sunda-Meya, Anderson; Phambu, Nsoki

doi:10.1080/00958970903377279

Cited by 9 publications

(12 citation statements)

References 38 publications

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“…The C=C bond can play an active role in binding too. 32 Reviewing the interaction of the adenine entity with divalent metal ions may illustrate a better understanding of the N donors in binding.…”

Section: Resultsmentioning

confidence: 99%

“…The ribose ring in ATP occurs as a weak Raman active mode and is visible as smeared out peaks in the range from 530.3 to 558.1 cm –1 . 32 Hydrolysis of ATP enhances the vibrational mode in the ribose ring and can be due to perturbation of other vibrational modes associated with the ribose ring. The sharp feature at 699.0 cm –1 is a feature of out-of-plane wagging of NH 2 bonds.…”

Section: Resultsmentioning

confidence: 99%

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Probing the Interaction at the Nano–Bio Interface Using Raman Spectroscopy: ZnO Nanoparticles and Adenosine Triphosphate Biomolecules

et al. 2014

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With the advent of nanobiotechnology, there will be an increase in the interaction between engineered nanomaterials and biomolecules. Nanoconjugates with cells, organelles, and intracellular structures containing DNA, RNA, and proteins establish sequences of nano–bio boundaries that depend on several intricate complex biophysicochemical reactions. Given the complexity of these interactions, and their import in governing life at the molecular level, it is extremely important to begin to understand such nanoparticle–biomaterial association. Here we report a unique method of probing the kinematics between an energy biomolecule, adenosine triphosphate (ATP), and hydrothermally synthesized ZnO nanostructures using micro Raman spectroscopy, X-ray diffraction, and electron microscopy experiments. For the first time we have shown by Raman spectroscopy analysis that the ZnO nanostructures interact strongly with the nitrogen (N7) atom in the adenine ring of the ATP biomolecule. Raman spectroscopy also confirms the importance of nucleotide base NH2 group hydrogen bonding with water molecules and phosphate group ionization and their pH dependence. Calculation of molecular bond force constants from Raman spectroscopy reinforces our experimental data. These data present convincing evidence of pH-dependent interactions between ATP and zinc oxide nanomaterials. Significantly, Raman spectroscopy is able to probe such difficult to study and subtle nano–bio interactions and may be applied to elegantly elucidate the nano–bio interface more generally.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Probing the Interaction at the Nano–Bio Interface Using Raman Spectroscopy: ZnO Nanoparticles and Adenosine Triphosphate Biomolecules

et al. 2014

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“…Fourier‐transform Infrared (FTIR) spectra of spherical particles further reveal the coordination of the carboxylate groups of 4,4′‐stilbenedicarboxylic acid linkers to Zn 2+ , as indicated by the large difference between the symmetric C=O stretching vibrations ( ν s =1607 cm −1 ) and asymmetric C=O stretching vibrations ( ν as =1380 cm −1 ) of the carboxylic group (Figure 2 a). Compared with the pure adenine, differences are observed in the imidazole ring region (1449 cm −1 ) and C‐NH stretching regions (1502 cm −1 ), indicating that adenine is bound to the metal ions by its N group (Figure S5) [14] . The X‐ray photoelectron spectroscopy (XPS) characterizations of the amorphous MOFs and pure adenine further indicate that metal ions are coordinated with adenine by sharing the electron pair of the N group (Figure S6), where the electron‐donating effect from N to metal ions result in an appreciable shift of the N 1s binding energy to a higher value and the Zn 2p binding energy to a lower value [15] .…”

Section: Figurementioning

confidence: 99%

Topological‐Distortion‐Driven Amorphous Spherical Metal‐Organic Frameworks for High‐Quality Single‐Mode Microlasers

Gao

Yang

et al. 2021

Angew Chem Int Ed

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Metal‐organic frameworks (MOFs) have recently emerged as appealing platforms to construct microlasers owing to their compelling characters combining the excellent stability of inorganic materials and processable characters of organic materials. However, MOF microstructures developed thus far are generally composed of multiple edge boundaries due to their crystalline nature, which consequently raises significant scattering losses that are detrimental to lasing performance. In this work, we propose a strategy to overcome the above drawback by designing spherically shaped MOFs microcavities. Such spherical MOF microstructures are constructed by amorphizing MOFs with a topological distortion network through introducing flexible building blocks into the growth environment. With an ultra‐smooth surface and excellent circular boundaries, the acquired spherical microcavities possess a Q factor as high as ≈104 and can provide sufficient feedback for high‐quality single‐mode lasing oscillations. We hope that these results will pave an avenue for the construction of new types of flexible MOF‐based photonic components.

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“…Previous studies on metal complexation with adenine have suggested that adenine is coordinated to metal ions through the N(1), N(3), N (7), and N(10) nitrogen atoms [2,3]. Recently, we have investigated the effects of some trivalent metal ions (Cr 3+ , Fe 3+ , and Al 3+ ) on free adenine, and we demonstrated that N-9-H of the free adenine is also involved in the metal ion binding (Scheme 1) [4]. Scheme 1 shows the atomic numbering system and all possible centers of attachments on adenine as well as the possible centers for forming a metal chelate.…”

Section: Introductionmentioning

confidence: 99%

Reactions of Zn2+, Cd2+ and Hg2+ with Free Adenine

Hamada¹

2013

J. Appl. Sol. Chem. Model.

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We are reporting the fluorescence quenching, IR, Raman, 1 H-NMR, and potentiometric studies for the Zn 2+ :adenine and the Cd 2+ :adenine systems under ambient conditions. IR and Raman spectra suggest that Zn 2+ and Cd 2+ interact with adenine but the modes of interaction differ. Fluorescence spectra indicate that the interaction involving Zn 2+ is more favorable than that of Cd 2+ , and this effect is due to the difference in ionic radii. 1 H-NMR, potentiometry, and speciation diagrams indicate the formation of strong metal ion adenine complexes. Potentiometric titrations of the heavier member of group 12 metals (Hg 2+ ) show similar results to that of Zn 2+ and Cd 2+ . Some differences in the 1 H-NMR experiments appeared between both (Zn 2+ and Cd 2+ ) compared to that of Hg 2+ . Due to the fluorescence quenching of adenine, adenine can be used as a sensor of Zn 2+ and Cd 2+ .

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Spectroscopic and potentiometric studies of the interaction of adenine with trivalent metal ions

Cited by 9 publications

References 38 publications

Probing the Interaction at the Nano–Bio Interface Using Raman Spectroscopy: ZnO Nanoparticles and Adenosine Triphosphate Biomolecules

Probing the Interaction at the Nano–Bio Interface Using Raman Spectroscopy: ZnO Nanoparticles and Adenosine Triphosphate Biomolecules

Topological‐Distortion‐Driven Amorphous Spherical Metal‐Organic Frameworks for High‐Quality Single‐Mode Microlasers

Reactions of Zn2+, Cd2+ and Hg2+ with Free Adenine

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