Spectroscopic and Thermal Characterization of Gliclazide, Glibenclamide and Glimeperide Complexes with Transition and Inner Transition Metals

Tawkir, Mohammad; Khairou, Khalid S.; Zaafarany, Ishaq

doi:10.13005/ojc/280420

Cited by 6 publications

(5 citation statements)

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“…5 It has been used since ancient times to heal wounds and plays an important role in the immune system, reproduction, growth, vision, blood clotting, proper insulin and thyroid function [6][7] Chelates of streptomycin are obtained by adding aqueous solutions of zinc salts to the solution of streptomycin at pH 9.0 (loc.cit). Zinc complex of sulpha drugs have been prepared and studied by Salil et al, 8 Bipin et al, 9 Sharma et al, 10 Iqbal and co-workers [11][12][13] and compare the antidiabetic properties of zinc complex with the parent drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Physico-chemical, Spectral and X-ray Diffraction Studies of Zn(II) Complex of Pioglitazone - A New Oral Antidiabetic Drug

Prakash¹,

Iqbal²,

Jacob³

2013

Orientjchem.

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Present paper deals with the synthesis, spectral characterization and X-ray diffraction study of Zn(II) complex with Pioglitazone a new oral antidiabetic drug. The conductometric titration using monovariation method indicate that complex is ionic and L 2 M type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. Analytical data agree with the molecular formula of complex viz. [(C 19 H 19 N 2 O 3 S) + 2 Zn]2Cl-. Structure of complex was assigned as tetrahedral, in which ligand molecules lies horizontally joining the central Zn(II) atom, supported by IR, 1 H NMR and Mass studies. X-ray diffraction data also supports the complex formation and symmetry of complex.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Physico-chemical, Spectral and X-ray Diffraction Studies of Zn(II) Complex of Pioglitazone - A New Oral Antidiabetic Drug

Prakash¹,

Iqbal²,

Jacob³

2013

Orientjchem.

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“…New bands are found in the spectra of complexes in the region 507 cm -1 which is assigned to M-O stretching vibrations. The proposed structure for the isolated complex is also supported by IR absorptions [12][13][14][15][16][17][18] .…”

Section: Infra-red Spectral Studiesmentioning

confidence: 87%

FTIR, UV-Vis, magnetic, mass spectral and XRD studies of Ni(II) complex with pioglitazone: An oral antidiabetic drug

Chouhan¹,

Jacob²

2014

Orient J Chem

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“…The high value of activation energies reflects the thermal stability of complex. The entropy of activation is found to have negative values in complex which indicate that decomposition reactions process with lower rate than the normal ones [26,[29][30][31][32][33]. In TGA curve (Figure 7) the initial loss (8.30%) (also given in Tables 4 and 5) is due to two molecules of water of crystallization (70-90 ∘ C) in complex which is in agreement with theoretically calculated percentage of water molecule, that is, 8.70%.…”

Section: Sharp-wentworth Methodsmentioning

confidence: 99%

Synthesis, Spectral Characterization, Magnetic Moment, Mass, X-Ray Diffraction, and Kinetic (TGA) Studies of Cr(III) Complex with Metformin: An Oral Antidiabetic Drug

Krishan

Iqbal²

2014

Journal of Chemistry

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The present work describes synthesis, spectral characterization, and X-ray diffraction studies of Cr(III) with “metformin,” an oral antidiabetic drug. The conductometric titration using monovariation method indicates that complex is ionic and of L2M type. Analytical data agree with the molecular formula of complex namely, [(C4H11N5)2Cr(H2O)2]2Cl. Geometry of complex assigned is octahedral, supported by IR, electronic spectra, magnetic moments,1H-NMR and mass studies, and proposed structure (I) for complex. X-ray diffraction data also supports the complex formation and symmetry of complex and various parameters like particle size, porosity, volume of unit cell, and density have been calculated. The Freeman-Carroll and Sharp-Wentworth methods have been used to calculate activation energy and thermal stability. The activation energy(Ea)calculated with the help of these methods are in agreement with each other. Thermodynamic parameters such as free energy change (ΔF) and entropy change are also determined on the basis of TG curves and by using data of the Freeman-Carroll method.

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Spectroscopic and Thermal Characterization of Gliclazide, Glibenclamide and Glimeperide Complexes with Transition and Inner Transition Metals

Cited by 6 publications

References 0 publications

Synthesis, Physico-chemical, Spectral and X-ray Diffraction Studies of Zn(II) Complex of Pioglitazone - A New Oral Antidiabetic Drug

Synthesis, Physico-chemical, Spectral and X-ray Diffraction Studies of Zn(II) Complex of Pioglitazone - A New Oral Antidiabetic Drug

FTIR, UV-Vis, magnetic, mass spectral and XRD studies of Ni(II) complex with pioglitazone: An oral antidiabetic drug

Synthesis, Spectral Characterization, Magnetic Moment, Mass, X-Ray Diffraction, and Kinetic (TGA) Studies of Cr(III) Complex with Metformin: An Oral Antidiabetic Drug

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