Synthesis, Physico-chemical, Spectral and X-ray Diffraction Studies of Zn(II) Complex of Pioglitazone - A New Oral Antidiabetic Drug

Abstract

Present paper deals with the synthesis, spectral characterization and X-ray diffraction study of Zn(II) complex with Pioglitazone a new oral antidiabetic drug. The conductometric titration using monovariation method indicate that complex is ionic and L 2 M type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. Analytical data agree with the molecular formula of complex viz. [(C 19 H 19 N 2 O 3 S) + 2 Zn]2Cl-. Structure of complex was assigned as tetrahedral, in which ligand molecules lies horizontally joining the central Zn(II) atom, supported by IR, 1 H NMR and Mass studies. X-ray diffraction data also supports the complex formation and symmetry of complex.

Valence Bond Sum (VBS) Analysis on Bis(dithiocarbamato) Nickel (II) and Complexes with NiS4 Chromophore

“…Valence bond parameters, R ij, available in the literature 7,9 for Ni-S, Ni-N, Ni-P, Ni-O are obtained from a statistical consideration of a very large number of homoleptic extended solid 7 . Use of those R ij values 7 , for isolated independent molecules of metallo-organic nature yielded very high VBS values leading to erroneous conclusion.…”

“…Use of those R ij values 7 , for isolated independent molecules of metallo-organic nature yielded very high VBS values leading to erroneous conclusion. Use of R ij values determined from homoleptic extended solids in the calculations of VBS for divalent zinc, cadmium and mercury metallo-organic compounds resulted in excellent agreement with the formal oxidation state of the metal 7,9 . The observation is a clear case of a more or less ionic interaction prevailing in metalloorganic compounds involving d 10 metal ions.…”

“…As it can be applied to estimate the bond lengths, vice-versa the sum of these bond lengths should give information about the valence of the central ion. Using the crystallographic data reported by our research group, the VBS calculations were made and results were published for a series of zinc, [5][6][7][8] . The VBS investigations for divalent zinc and cadmium dithiocarbamte complexes resulted in excellent agreement with the formal oxidation state of the metal.…”

Synthesis of Polyamide-6/Montmorillonite Nanocomposites by Direct In-situ Polymerization Catalysed by Exchanged Clay

“…For the spectrum of PANC3, the same bands appear just the absorption of N-H (appears at 3294.87 cm -1) and C=O (appears at 1631.55 cm -1) show obvious displacement to lower frequency compared to neat PA6. In consideration of the fact that there are plentiful silanol groups on the surface of nanosilica, these results should indicate the existence of hydrogen bonds between PA6 and nano-silica [28][29][30] .…”

Microcalorimetric Study of the Catalytic Properties of SBA-15 Modified with Cu or Fe for Adsorption/oxidation of Methyl mercaptane

“…However, silanol groups í(Si-OH) in pure mesoporous silica materials can also contribute to this band 39 . Therefore, there is some dispute over the assignment of the band at 990 cm -1 [40][41][42][43] . In order to solve the problem of the assignment, it is necessary to measure the IR spectra in situ at elevated temperatures.…”