Spectroscopic Characterization,<i>In Vitro</i>Cytotoxicity, and Antioxidant Activity of Mixed Ligand Palladium(II) Chloride Complexes Bearing Nucleobases

Tetteh, Samuel; Dodoo, D.K.; Appiah–Opong, Regina; Tuffour, Isaac

doi:10.1155/2014/586131

Cited by 18 publications

(14 citation statements)

References 42 publications

(42 reference statements)

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“…The increased antioxidant activity of these complexes (Table 4) can be attributed to the electron withdrawing effect of the Zn(II), Ni(II), Cu(II) and Co(II) ions which facilitates the release of hydrogen to reduce the DPPH radical [13]. This proton release were very pronounced in Cu(DEP), with an IC 50 value of 2.08 ± 0.47 µM, followed by Ni(DEP) [2.52 ± 1.15 µM], Co(DEP) (3.04 ± 0.59 µM) and Zn(DEP) (3.64 ± 1.65 µM).…”

Section: Resultsmentioning

confidence: 99%

“…An antioxidant can be defined as any substance that when present at low concentrations compared with those of an oxidizable substrate [11] can inhibit the oxidation of lipids or other molecules by preventing the initiation or propagation of oxidative chain reactions and can thus prevent or repair the damage done to the body’s cells by oxygen [12]. Metal-based antioxidants have gained attention recently for their capacity to protect organisms and cells from damage induced by oxidative stress or scavenge free radicals [13]. These metal complex derivatives which show considerable biological activity, may represent an interesting approach for designing new antibacterial drugs.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base

2015

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Co(II), Ni(II), Zn(II) and Cu(II) complexes of (3E)-3-[(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one (DEPH2) derived from ethylenediamine, 2′,4′-dihydroxyacetophenone and 1-phenylbutane-1,3-dione have been synthesized and characterized by elemental analysis, FTIR, UV-Visible spectroscopy, and screened to establish their potential as antibacterial agents, antioxidants and DPPH radical scavengers. The FTIR spectra showed that the ligand behaves as a dibasic tetradentate ligand with the dioxygen-dinitrogen donor atom system oriented towards the central metal ion. The analytical and spectroscopic data suggest a square planar geometry for Cu(II) and Ni(II) complexes and an octahedral geometry for the Co(II) complex. The ligand and their metal complexes were screened for antibacterial activity against Gram (+) and Gram (−) bacteria by the agar well diffusion method. In addition, the antioxidant activities of the complexes were also investigated through their scavenging effect on DPPH and ABTS radicals. The obtained IC50 value of the DPPH activity for the copper complex (2.08 ± 0.47 µM) and that of the ABTS activity for the copper complex (IC50 = 2.11 + 1.69 µM) were higher than the values obtained for the other compounds.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base

2015

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“…Then, the same protocol was applied for synthesizing the other two ligands (Z 2 ) and (Z 3 ) by refluxing the ethanolic solution of 2-amino-6-ethoxybenzothiazole and 2-amino-6-nitrobenzothiazole with 5-chloroisatin, respectively. (12), 310 (21), 291 (38), 270 (24), 247 (63), 232 (16), 203 (20), 192 (100), 171 (69) 152 (39), 134 (30), 120 (41), 95 (10), 81 (25), 76 (09), 43 (11) (12), 313 (23), 293 (39), 282 (10), 266 (23), 196 (10), 194 (80), 168 (08), 165 (100), 140 (07), 139 (29), 110 (22), 95 (08), 80 (11), 69 (17) (36), 197 (81), 165 (78), 149 (24), 137 (20), 122 (100), 105 (17), 95 (22), 78 (16)…”

Section: Synthesis Of Ligands (Z 1 )-(Z 3 )mentioning

confidence: 99%

Metal incorporated aminothiazole-derived compounds: synthesis, density function theory analysis,in vitroantibacterial and antioxidant evaluation

et al. 2021

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The present study advocates the combined experimental and computational study of metal-based aminothiazole-derived Schiff base ligands. The structure and electronic properties of ligands have been experimentally studied by spectroscopic methods (UV-Vis, FT-IR, 1 H-NMR and 13 C-NMR), mass spectrometry, elemental analysis and theoretically by density function theory (DFT). Computational calculations employing the B3LYP/6-31 + G(d,p) functional of DFT were executed to explore the optimized geometrical structures of ligands along with geometric parameters, molecular electrostatic potential (MEP) surfaces and frontier molecular orbital (FMO) energies. Global reactivity parameters estimated from FMO energy gaps signified the bioactive nature of ligands. The synthesized ligands were used for chelation with 3 d -transition metals [VO(IV), Cr(III), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)] in 1 : 2 (metal : ligand) molar ratio. The spectral and magnetic results confirmed the formation of octahedral geometry around all the divalent and trivalent metal centres, whereas the tetravalent vanadyl centres were confirmed to have square-pyramidal geometry. All the as-synthesized compounds were investigated for in vitro antibacterial potential against two Gram-negative ( Salmonella typhimurium and Escherichia coli ) and two Gram-positive ( Bacillus subtilis and Staphylococcus aureus ) bacteria. Antibacterial assay results displayed pronounced activity, and their activity is comparable to that of a standard drug (streptomycin). The antioxidant potential of these compounds was assessed by employing diphenyl picryl hydrazide radical scavenging activity. The results displayed that all the metal chelates have exhibited more bioactivity in contrast with free ligands. The chelation was the main reason for their enhanced bioactivity. These results indicated that the thiazole metal-based compounds could be exploited as antioxidant and antimicrobial candidates.

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“…All the metal complexes showed comparable or less activity than that of standard (Ascorbic acid). The high antioxidant potential of these complexes can be recognized to the electron retreating consequences of the Cu(II), Ni(II), Zin(II) and Cd(II) ions which assisted the liberate of hydrogen to squeeze the DPPH free radical (Tetteh et al 2014).…”

Section: Anti-oxidant Studymentioning

confidence: 99%

Synthesis, Characterization and Biological Activities of Hydrazone Schiff Base and its Novel Metals Complexes

Hussain¹,

Ullah²,

Khan³

et al. 2019

JSM

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Recently, researchers are focusing on the synthesis of Schiff base complexes due to their promising biological activities and frequent use in the pharmaceuticals. In the present study we synthesized Schiff base of salicyldehyde and 2, 4-dinitrophenylhydrazine by modified method and its novel metal complexes with Cu (II), Zn (II), Co (II), Ni (II), Mn (II), V (II) and AU (IIII). For spectroscopic studies and characterization, UV-Vis and FT-IR spectroscopy were used. The Schiff base and its metals complexes were tested for antimicrobial, cytotoxic and antioxidant activities. Significant results are showed by the all synthesized complexes.

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Spectroscopic Characterization,In VitroCytotoxicity, and Antioxidant Activity of Mixed Ligand Palladium(II) Chloride Complexes Bearing Nucleobases

Cited by 18 publications

References 42 publications

Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base

Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base

Metal incorporated aminothiazole-derived compounds: synthesis, density function theory analysis,in vitroantibacterial and antioxidant evaluation

Synthesis, Characterization and Biological Activities of Hydrazone Schiff Base and its Novel Metals Complexes

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