Spectroscopic Studies, Biological Activity, and Cytotoxicity of Some Binary and Ternary Palladium and Platinum Complexes of Certain Heterocyclic Ligands

Abstract

Binary and ternary palladium and platinum complexes were synthesized from [MCl 4 ] 2¡ with certain heterocyclic ligands containing nitrogen and oxygen donors and a secondary ligand (pyridine or bipyridine). Complexes were characterized by elemental analysis, mass, IR, and 1 H NMR spectroscopy. Biological activities of ligands and complexes against the Escherchia coli and Staphylococcus aureus bacteria, and the two fungi Aspergillus flavus and Candida albicans were screened. The cytotoxicity of the two complexes [Pt (PCA)(Py)(Cl)]Cl and [Pt(PCA)(m-Cl) 2 (Bpy)]Cl 2 were checked as antitumor agents on two breast cancer and liver carcinoma cell lines. They exhibited higher in vitro activities toward the tumors relative to cisplatin.

Synthesis, Spectroscopic, and DFT Studies of Some Platinum-Pyrazine Carboxamide Derivatives

“…However, their drug resistance and side effects have limited their clinical use. Vast efforts are committed to develop novel transition metal-based derivatives, such as platinum(II), platinum(IV) and ruthenium complexes, which might overcome the disadvantages of cis-platin and have higher antitumor activity as well [2,3,4,5]. Considerable amount of interest has focused on the use of pyridine platinum(II) complexes as mimics of cis-platin [6].…”

“…Our interest in the synthesis of various transition metal complexes with heterocyclic ligands that have appropriate Scheme 1: Structure of ligands. biological activities and show promising applications as antitumor drugs [3,4] has prompted us to synthesize and investigate other platinum(II) and platinum(IV) complexes of these ligands (Scheme 1). In this article, we report the synthesis, and characterization of some Pt(II) and Pt(IV) complexes with nitrogen heterocyclic ligands.…”