Spectroscopic studies of amphotericin B–Cu2+ complexes

Gagoś, Mariusz; Czernel, Grzegorz; Kamiński, Daniel; Kostro, K.

doi:10.1007/s10534-011-9445-2

Cited by 19 publications

(25 citation statements)

References 38 publications

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“…Unfortunately, AmB is toxic to humans and forms concrements in the liver, kidneys, and the brain (Gagoś et al, 2011). As we found, AmB is also deposited in honeybee hindguts (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous side effects, such as nephrotoxic activity, hepatotoxic activity, and in higher doses -neurotoxic and hemolytic activities are induced by AmB (Gallis et al, 1990). One of the main problems of AmB treatment is related to its aggregation (Espada et al, 2008;Gagoś et al, 2011). It was recently found by Gagoś et al (2011), that the formation of AmB-Cu 2+ complexes is linked to the disaggregation of AmB.…”

Section: Introductionmentioning

confidence: 99%

“…One of the main problems of AmB treatment is related to its aggregation (Espada et al, 2008;Gagoś et al, 2011). It was recently found by Gagoś et al (2011), that the formation of AmB-Cu 2+ complexes is linked to the disaggregation of AmB. This may facilitate practical applications of AmB.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Amphotericin B on the Lifespan, Body-surface Protein Concentrations, and DNA Methylation Levels of Honey Bees (Apis mellifera)

Strachecka¹,

Borsuk²,

Olszewski³

et al. 2012

Journal of Apicultural Science

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S u m m a r y Three groups of caged bees were fed with sugar syrup (the control), sugar syrup supplemented with amphotericin B (AmB) in a dose of 0.5 mg/ml, and sugar syrup with AmB in a dose of 0.25 mg/ ml. Amphotericin B shortened the life span of the bees and reduced the level of global DNA methylation compared to the control, however, it increased the body-surface protein concentrations. In the hindguts of the bees, there were found AmB deposits. Honeybees appear to be a useful model for studying the side effects of anti-fungal AmB therapy. Among other things, epigenetic changes and senescence acceleration are considered to be the side effects of the therapy.

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“…Unfortunately, AmB is toxic to humans and forms concrements in the liver, kidneys, and the brain (Gagoś et al, 2011). As we found, AmB is also deposited in honeybee hindguts (Fig.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Amphotericin B on the Lifespan, Body-surface Protein Concentrations, and DNA Methylation Levels of Honey Bees (Apis mellifera)

Strachecka¹,

Borsuk²,

Olszewski³

et al. 2012

Journal of Apicultural Science

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“…Complexes of amphotericin B with copper(II) ions were prepared as previously described (Gagoś et al, 2011). To obtain oxidized forms, dissolved AmB was diluted in acidic water (pH 2.2) and then incubated with 0.050 mg of iron(III) chloride (per 0.5 mg of AmB) for 165 min at room temperature.…”

Section: Cell Culture Conditionsmentioning

confidence: 99%

Expression profiles of genes related to melatonin and oxidative stress in human renal proximal tubule cells treated with antibiotic amphotericin B and its modified forms

Gola

Skubis²,

Sikora³

et al. 2015

Turk J Biol

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It acts through membrane receptors (MT1 and MT2), nuclear receptors (ROR/RZR -retinoid orphan receptors/ retinoid Z receptors), and nonreceptor-mediated mechanisms (Slominski et al., 2012). Melatonin, through its antioxidant properties, protects against damage of cellular components including DNA, cytosolic proteins, and cell membrane lipids (Yürüker et al., 2015). Studies on the antioxidant properties of melatonin are most commonly associated with agents that induce free radicals in cells (Nazıroğlu et al., 2013). Antibiotics also induce the generation of free radicals. One of them, amphotericin B (AmB), causes lipid peroxidation through generation of reactive oxygen species (ROS). AmB belongs to the group of polyene antibiotics and is an effective antifungal drug commonly used to treat systemic mycoses. It is believed that the fungicidal activity is due to the binding of AmB with the ergosterol present in the cell membrane of fungi, resulting in membrane permeabilization and osmotic imbalance (Brajtburg et al., 1990;Paulo et al., 2013). One of the mechanisms leading to fungal cell death is leakage of potassium ions caused by formation of ion channels in the cell membrane as a consequence of AmB binding with ergosterol (Chudzik et al., 2015). This situation leads to the generation of ROS and lipid peroxidation (Mesa-Arango et al., 2012). Unfortunately, AmB, besides its affinity to ergosterol, also shows an affinity to cholesterol present in human cell membranes, causing nephrotoxic and hepatotoxic side effects (Antonowicz-Juchniewicz et al.

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“…Its structure was established in 1970 . Numerous scientific studies concerning the aggregation effect in the pharmacological properties, as well as its toxicity, have been published in recent years …”

Section: Introductionmentioning

confidence: 99%

SERS as a valuable tool for detection and treatment follow‐up of fungal infection in mice lungs: use of Amphotericin B and its nanoencapsulation onto magnetic nanoparticles

Santos

Silva

Saldanha

et al. 2013

J Raman Spectroscopy

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This study reports on the use of surface‐enhanced Raman scattering (SERS) detection and follow‐up treatment of Paracoccidioides brasiliensis (Pb) infection in lung's mice. We also reports on the introduction of a new drug carrier system [nanoparticle‐Amphotericin B (NP‐AmB)], comprising magnetic NP surface functionalized with AmB, and its use in the treatment of infected and non‐infected mice. SERS was successfully used to monitor the efficacy of the mice's treatment using the new NP‐AmB, while free AmB (F‐AmB), considering the current drug of choice for treatment of Pb infection, was also used and taken as reference for the treatment. We found SERS provides a robust platform to discriminate infected lung tissues from non‐infected ones based on fingerprints assessed via SERS spectra and focused on the redox state of heme groups present in the collected biological material. Finally, SERS data reported in this study indicated that the new NP‐AmB formulation provides similar clinical response as the F‐AmB, although incorporating 40% lower content of AmB and administered in a time interval schedule (every 72 h) three times longer than F‐AmB (every 24 h). Copyright © 2013 John Wiley & Sons, Ltd.

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Spectroscopic studies of amphotericin B–Cu2+ complexes

Cited by 19 publications

References 38 publications

The Effect of Amphotericin B on the Lifespan, Body-surface Protein Concentrations, and DNA Methylation Levels of Honey Bees (Apis mellifera)

The Effect of Amphotericin B on the Lifespan, Body-surface Protein Concentrations, and DNA Methylation Levels of Honey Bees (Apis mellifera)

Expression profiles of genes related to melatonin and oxidative stress in human renal proximal tubule cells treated with antibiotic amphotericin B and its modified forms

SERS as a valuable tool for detection and treatment follow‐up of fungal infection in mice lungs: use of Amphotericin B and its nanoencapsulation onto magnetic nanoparticles

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